Investigating the link between obstructive sleep apnea and pulmonary hypertension
Prevalence, Phenotypes, Predictors and Prognostic Implication of Obstructive Sleep Apnea in Pulmonary Hypertension
This study looks at how common sleep apnea is in adults with pulmonary hypertension and how it affects their health.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 480 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Chinese Pulmonary Vascular Disease Research Group Academic / other |
| Locations | 1 site (Beijing) |
| Trial ID | NCT05595200 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the prevalence, phenotypes, and predictors of obstructive sleep apnea (OSA) in patients diagnosed with pulmonary hypertension. Adult participants will undergo an overnight cardiorespiratory study using a Level III portable device to assess their sleep patterns and related physiological parameters. The study will categorize patients into OSA and non-OSA groups based on their apnea-hypopnea index (AHI) and collect data on hypoxemic parameters and baseline clinical characteristics. The goal is to determine the impact of OSA on clinical outcomes in this patient population.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 and older who have been diagnosed with pulmonary hypertension through right heart catheterization.
Not a fit: Patients who are pregnant, have central sleep apnea, or have previously received treatment for sleep-disordered breathing may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve risk assessment and therapeutic recommendations for patients with pulmonary hypertension by identifying the prognostic implications of obstructive sleep apnea.
How similar studies have performed: Other studies have indicated a higher prevalence of obstructive sleep apnea in patients with pulmonary hypertension, suggesting that this approach could yield valuable insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Aged ≥18 years old * Diagnosed with pulmonary hypertension by right heart catheterization Exclusion Criteria: * Pregnancy * Central sleep apnea * Previous treatment for sleep-disordered breathing * Unavailable or incomplete sleep data * Requiring nocturnal oxygen supplementation
Where this trial is running
Beijing
- Center for Respiratory and Pulmonary Vascular Diseases, Fuwai hospital, CAMS & PUMC — Beijing, China (Recruiting)
Study contacts
- Principal investigator: Zhihong Liu — Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
- Study coordinator: Zhihong Liu, M.D., Ph.D
- Email: zhihongliufuwai@163.com
- Phone: +861088396590
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.