Regulatory T Cells and Lung Disease-Related High Blood Pressure in Adults
Official title: Regulatory T Cells And Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension
Funded at Baylor College of Medicine · NIH-11399081 · Data updated 2026-11-12
This project studies how a type of immune cell called regulatory T cells may influence inflammation and blood vessel changes in lung disease, with potential relevance to adults who have vascular issues in their lungs.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $699,684 |
| NIH project number | 5R01HL181470-02 |
| Project ID | NIH-11399081 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with lung conditions associated with inflammation and vascular changes, including those at risk for or with bronchopulmonary dysplasia–related pulmonary hypertension.
✕Less likely to help
Individuals without inflammatory lung disease or pulmonary vascular involvement are unlikely to benefit.
What this research studies
Researchers will use mouse models and human lung samples to explore how regulatory T cells affect inflammation and blood vessel health in lung disease. The work aims to understand whether boosting or adjusting these T cells could help prevent or treat pulmonary hypertension that sometimes accompanies lung injury. By examining interactions between regulatory T cells and lung endothelial cells, the study seeks clues for new therapies for patients with lung diseases that involve inflammation and vascular changes. Findings could point toward strategies to improve lung development and function in affected adults and inform future clinical trials.
Why it matters
Potential benefit: If successful, the research could lead to new ways to reduce inflammation and protect lung blood vessels, potentially lowering risk of pulmonary hypertension in patients with inflammatory lung diseases.
How similar studies have gone: Preliminary data in animals suggest regulatory T cells influence lung inflammation and vascular density, supporting potential relevance to humans.
Where this research is happening
-
Baylor College of Medicine
Houston, United States Active
Researchers
- Principal investigator: Shivanna, Binoy — Baylor College of Medicine
- Study coordinator: Shivanna, Binoy
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.