Using hyperpolarized 129Xe MRI to assess lung function in healthy individuals and those with lung diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of hyperpolarized (HP) 129Xe gas MRI for assessing regional lung function in both healthy volunteers and individuals diagnosed with pulmonary diseases such as asthma, COPD, and cystic fibrosis. Approximately 160 subjects with pulmonary conditions and 100 healthy controls will participate in this open-label study. Participants will undergo imaging on an outpatient basis, receiving multiple doses of HP 129Xe gas, along with conventional MRI scans to provide anatomical context. The study will take place at the University of Kansas Medical Center.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Healthy Volunteers:

* Subject has no diagnosed pulmonary conditions
* Ability to read and understand English or Spanish

Subjects with Lung Disease:

* Subject has a diagnosis of pulmonary dysfunction made by a physician
* No acute worsening of pulmonary function in the past 30 days
* Ability to read and understand English or Spanish

Exclusion Criteria:

* MRI is contraindicated based on responses to MRI screening questionnaire
* Subject is pregnant or lactating
* Subject does not fit into 129Xe vest coil used for MRI
* Subject cannot hold his/her breath for 15-16 seconds
* Subject deemed unlikely to be able to comply with instructions during imaging
* Oxygen saturation \<88% on room air or with supplemental oxygen
* Cognitive deficits that preclude ability to provide consent
* Institutionalization

Where it's running

• University of Kansas Medical Center
  Kansas City, Kansas, United States Recruiting

Study contacts

• Principal investigator: Peter Niedbalski, PHD — University of Kansas Medical Center
• Study coordinator: Cristal Monge
• Email: chernandez@kumc.edu
• Phone: 913-945-9399

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.