Cardiovascular health in children and young adults with chronic conditions

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study will enroll participants aged 6-25 who have chronic childhood conditions linked to higher cardiovascular risk. Investigators will use noninvasive measures such as carotid artery imaging and retinal vessel imaging alongside clinical measures of inflammation and metabolic status to characterize vascular aging. The study will consider disease-related factors (for example diabetes or chronic kidney disease), treatment-related effects (such as long-term steroids or chemotherapy), and lifestyle-related contributors. The goal is to identify early vascular markers and underlying mechanisms that could guide future monitoring and prevention strategies.

Why it matters

Who can join: the full rules

Inclusion criteria:

1. Individuals aged between 6 and 25 years;
2. Diagnosed with a chronic childhood condition/disease associated with an increased risk of early cardiovascular disease;
3. Provided informed consent (if over 18 years old) or had informed consent provided by their legal guardian (if under 18 years old) following appropriate information about the study.

Chronic childhood conditions/diseases associated with increased risk of early cardiovascular disease are defined according to the 2019 American Heart Association recommendations (https://doi.org/10.1161/CIR.0000000000000618), as well as other conditions/diseases for which at least two large-scale epidemiological studies have demonstrated an increased risk of cardiovascular disease.

Exclusion criteria:

1. Severe intellectual and developmental disability;
2. Decompensated heart failure;
3. Severe primary immunodeficiency;
4. Ongoing intravenous chemotherapy;
5. Infectious diseases posing a public health risk; or
6. History of regular alcohol or drug use.

Where it's running

• Semmelweis University, Pediatric Center
  Budapest, Hungary Recruiting
• Semmelweis University, Department of Surgery, Transplantation and Gastroenterology
  Budapest, Hungary Not yet recruiting
• Semmelweis University, Institute of Preventive Medicine and Public Health
  Budapest, Hungary Active not recruiting

Study contacts

• Principal investigator: Tamas Kiss, MD, PhD — Semmelweis University, Pediatric Center
• Study coordinator: Tamas Kiss, MD, PhD
• Email: kiss.tamas1@semmelweis.hu
• Phone: +36202478885

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.