Understanding how heart failure affects lung blood vessels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the mechanisms behind pulmonary vascular dysfunction in patients with heart failure, particularly focusing on the metabolic factors that contribute to this condition. By utilizing untargeted metabolomics and advanced imaging techniques, the study aims to identify novel biomarkers and pathways associated with pulmonary vascular disease. Participants will undergo right heart catheterization and various non-invasive tests to gather comprehensive data on their heart and lung function. The findings could lead to targeted therapies for patients suffering from heart failure-related pulmonary vascular issues.

Why it matters

Who can join: the full rules

A) Inclusion Criteria

HF group:

* age\>18y
* signed informed consent,
* left ventricular (LV) ejection fraction \<50%
* duration of HF\>6 months,
* loop diuretic use,
* clinical indication to right heart catheterisation

Control group:

* Age \>18years
* Signed informed consent
* Non-HF subjects referred to Institute for Clinical and Experimental Medicine (IKEM) in Prague for an invasive procedure (PFO closure, arrhythmia ablation, for subjects undergoing RHC) or non-invasive diagnostic evaluation (controls without invasive sampling)

B) Exclusion Criteria:

Heart Failure group:

* Patients with hemodynamic instability requiring inotropic support
* Severe renal insufficiency (estimated glomerular filtration rate \<0.6 ml/s)
* Acute coronary syndrome
* High cardiac output (cardiac index \>4 l/m2)
* Known pulmonary hypertension of other type than II (type I, III, IV)
* Active infection
* Respiration insufficiency
* Large pleural effusion
* Severe intrinsic lung disease (treated chronic obstructive pulmonary disease (COPD)

  * asthma, known interstitial lung disease)

Control group:

* Pulmonary hypertension (RV systolic pressure estimate on screening \> 45 mmHg)
* History of recent pulmonary embolism \< 1 year
* Echocardiographic evidence of reduced function of right or left ventricle
* Treated asthma/COPD, known intersticial lung disease
* Significant exercise intolerance (NYHA \> II)

Where it's running

• Institute for Clinical and Experimental Medicine - IKEM
  Prague, Czechia Recruiting

Study contacts

• Principal investigator: Vojtech Melenovsky — Institute for Clinical and Experimental Medicine
• Study coordinator: Vojtech Melenovsky, MD, PhD
• Email: vome@ikem.cz
• Phone: 420 236055190

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.