Optimal vasopressor choice for newborns with PPHN

Who could benefit from this research

What this research studies

In newborns with perinatal asphyxia and PPHN, blood pressure and heart function are challenged, especially after therapeutic hypothermia. The project plans a randomized comparison of dopamine, norepinephrine, epinephrine, and vasopressin to see how each drug affects systemic versus pulmonary blood flow, heart function, and overall perfusion. By understanding which vasopressor best balance SVR and PVR, clinicians may improve oxygen delivery and reduce hypoxemia. The work will explore vascular and cellular responses to these drugs in the context of PPHN and oxygen therapy. If successful, findings could guide safer, more effective management of vasopressor support in affected newborns.

Why it matters

Where this research is happening

• University of California at Davis
  Davis, United States Active

Researchers

• Principal investigator: Sankaran, Deepika — University of California at Davis
• Study coordinator: Sankaran, Deepika

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.