Exercise program for children with pulmonary hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention focuses on increasing physical activity in children and teenagers aged 8-18 with pulmonary hypertension (PH) through a 16-week exercise program. Utilizing wearable activity monitoring devices, the study aims to promote exercise and improve skeletal muscle mass, which is often deficient in this population. The program targets children with WHO functional class I or II PH, who are ambulatory and have stable medication regimens. By addressing exercise intolerance, the study seeks to enhance both exercise performance and quality of life for these young patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 8-18 years
* PH World Health Organization (WHO) diagnostic groups 1, 2, 3, or 4 (pulmonary arterial hypertension, PH due to left heart disease, PH due to lung disease, chronic thromboembolic PH)
* WHO functional class I or II
* Ambulatory status
* Mean pulmonary to systemic arterial pressure ratio \<0.75 if the patient has not undergone a pulmonary to systemic artery shunt ("Potts" shunt) OR the placement of a Potts shunt ≥ 6 months prior to study enrollment
* Stable PH medication regimen for 3 months prior to the intervention
* Home Wifi connection
* Mobile device in family capable of receiving text messages

Exclusion Criteria:

* WHO functional class III or IV
* Single ventricle physiology
* Moderate to severe renal disease (\>stage 3)
* Severe hepatic impairment \[aspartate aminotransferase (AST)/alanine transaminase (ALT) \> 2x upper limit of normal\]
* Current pregnancy
* Significant developmental delay/inability to comply with verbal instructions to complete the study procedures

Where it's running

• Children's Hospital of Philadelphia
  Philadelphia, Pennsylvania, United States Recruiting

Study contacts

• Study coordinator: Catherine Avitabile, MD
• Email: avitabilec@chop.edu
• Phone: 215-590-4040

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.