Amino“peptidase N” signaling in pulmonary hypertension
Official title: Aminopeptidase N Driven Signaling in the Development of Pulmonary Hypertension
Funded at Indiana University Indianapolis · NIH-11381013 · Data updated 2026-11-12
A researcher is exploring how a specific enzyme, Aminopeptidase N, and mitochondrial dysfunction may drive pulmonary hypertension, with a plan to develop an independent lab career.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | August 1, 2025 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $248,999 |
| NIH project number | 5R00HL171869-04 |
| Project ID | NIH-11381013 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient participation; this is a career-development grant.
✕Less likely to help
Patients will not be enrolled in this grant as described.
What this research studies
This grant supports a researcher to build an independent line of investigation on how Aminopeptidase N and mitochondria contribute to pulmonary hypertension, including hands-on training, data generation, and presentation at conferences. The work will take place under expert mentors at Indiana University in Indianapolis, using methods like single-cell transcriptomics, cell culture, and electrophysiology. The goal is to produce preliminary data and publications that establish the investigator’s ability to lead future studies and grants. The program also emphasizes professional development and mentoring to ensure a strong transition to independent funding.
Why it matters
Potential benefit: If successful, the research could uncover new mechanisms and targets for treating pulmonary hypertension in patients.
How similar studies have gone: Previous work in related pathways suggests potential relevance, but the exact APN-mitochondria link in PH remains to be validated.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: James, Joel — Indiana University Indianapolis
- Study coordinator: James, Joel
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.