Condition

Pulmonary Arterial Hypertension clinical trials and research

• 49Clinical trials
• 97NIH research projects
• 42Countries

Newest Pulmonary Arterial Hypertension clinical trials

All recruiting trials (49)

• Understanding how low-load leg exercises affect muscle and blood flow in PAH patients

  This substudy tests whether a gentle leg exercise program can change blood flow and oxygen use in the calf muscles of adults with pulmonary arterial hypertension.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07781709

• Sotatercept in Japanese children with pulmonary arterial hypertension

  This study tests whether sotatercept is safe and well tolerated in Japanese children with PAH when added to standard PAH treatment.

  Recruiting at 3 sites Phase 2 Merck Sharp & Dohme LLC · Izumi, Osaka and 2 other locations · NCT07646860

• DIAG723 in Adults With HHT

  A first-in-human study tests DIAG723 versus placebo in adults with hereditary hemorrhagic telangiectasia to see if it is safe and possibly helpful.

  Recruiting at 3 sites Phase 1/2 Diagonal Therapeutics, Inc. · Camperdown, New South Wales and 10 other locations · NCT07623525

• See if 18F-FAPI-74 PET/CT can better detect fibrosis in heart and lung disease

  Researchers are testing a new PET/CT tracer, 18F-FAPI-74, to see if it can reveal early fibrotic changes in people with heart and lung diseases who are at risk for tissue scarring.

  Recruiting Phase 3 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT07613099

• Sotatercept in Indian adults with pulmonary arterial hypertension on standard therapy

  This study tests whether adding sotatercept to current PAH medicines is safe and tolerable for adults with PAH in India.

  Recruiting at 3 sites Phase 4 Merck Sharp & Dohme LLC · Hyderabad, Andhra Pradesh and 2 other locations · NCT07600723

• Once-daily treprostinil palmitil inhalation powder for PAH

  This study tests whether taking a daily inhaled treprostinil palmitil powder for 24 weeks improves exercise ability in adults with pulmonary arterial hypertension compared to a placebo.

  Recruiting at 39 sites Phase 3 Insmed Incorporated · Los Angeles, California and 38 other locations · NCT07481981

• NS-863 in Pulmonary Arterial Hypertension (PAH) - a mid-stage test in adults

  This Phase 2 trial tests NS-863 at low and high doses versus placebo in adults with PAH to see if it helps with symptoms and safety.

  Recruiting Phase 2 NS Pharma, Inc. · Kitakyushu · NCT07441200

• Home-based exercise plus medication for people newly diagnosed with pulmonary arterial hypertension

  This trial will try a 12-week home-based, remotely supervised exercise program added to usual medication for adults newly diagnosed with pulmonary arterial hypertension to see if it improves fitness, quality of life, and mental wellbeing.

  Recruiting Golden Jubilee National Hospital · Glasgow · NCT07366879

• IKT-001 for adults with pulmonary arterial hypertension (PAH)

  This Phase 3 program will test whether IKT-001 can improve symptoms and hemodynamics in adults with WHO Group 1 PAH who are already on stable PAH therapy.

  Recruiting at 43 sites Phase 3 Inhibikase Therapeutics · Scottsdale, Arizona and 42 other locations · NCT07365332

• Cardiac and fetal health in pregnancy at high altitude

  This observational study tests how living at high altitude affects heart function and fetal growth in pregnant women, compared with similar pregnancies at sea level.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts and 1 other locations · NCT07312227

• Rutgers Genetics of Pulmonary Hypertension

  This online project will try to see if genetic differences affect the risk of pulmonary hypertension in U.S. adults, and anyone 18 or older can join whether or not they have PH.

  Recruiting Rutgers, The State University of New Jersey · Piscataway, New Jersey · NCT07217522

• HS235 for PAH in Adults: Adding an Activin Inhibitor to Background Therapy

  This study tests HS235 to see if adding it to patients' existing PAH treatment helps adults with pulmonary arterial hypertension.

  Recruiting at 7 sites Phase 1/2 35Pharma Inc., a GSK company · Tampa, Florida and 6 other locations · NCT07143448

• Switching endothelin receptor medicines and risk in pulmonary arterial hypertension

  This study will try switching adults with PAH from ambrisentan to bosentan to see if the change alters their clinical risk profile and liver safety.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT07013149

• Timing of pulmonary arterial hypertension diagnosis in Brazil

  We will see how long it takes adults with pulmonary arterial hypertension in Brazil to get a confirmed diagnosis and what causes delays.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06998329

• Empagliflozin to Help the Right Side of the Heart in PAH

  This trial tests whether taking empagliflozin daily for 6 months helps right heart function in adults with pulmonary arterial hypertension who are already on approved PAH medicines.

  Recruiting at 3 sites Phase 2 The Cleveland Clinic · Baltimore, Maryland and 2 other locations · NCT06992440

• Quality control of right heart catheterization for pulmonary vascular diseases in China

  This study looks at the quality of right heart catheterization procedures for people with suspected pulmonary hypertension in China to see how well they are being done and what outcomes patients experience.

  Recruiting China-Japan Friendship Hospital · Beijing · NCT06954727

• Improving adherence to PAH treatment with telemedicine and patient guidance

  This study will try whether regular telemedicine check-ins and guided education help people with PAH stick to their oral medications and manage side effects.

  Recruiting University of Sao Paulo General Hospital · São Paulo, São Paulo · NCT06850792

• Testing APL-9796 for adults with pulmonary hypertension

  This study is testing a new treatment called APL-9796 to see if it is safe and helps adults with pulmonary hypertension feel better.

  Recruiting at 6 sites Phase 2 Apollo Therapeutics Ltd · London, London and 5 other locations · NCT06846554

• Exercise rehabilitation for patients with pulmonary artery disease

  This study is testing a group exercise program to see if it can help people with pulmonary arterial hypertension feel better and be more active.

  Recruiting Tampere Heart Hospital · Tampere, Pirkanmaa · NCT06804122

• Sotatercept to support right ventricular function in pulmonary arterial hypertension

  This research will try sotatercept injections in adults with PAH to see if the medicine helps the right side of the heart work better.

  Recruiting Phase 4 Amsterdam UMC, location VUmc · Amsterdam, North Holland · NCT06658522

• Using a new device to treat severe pulmonary arterial hypertension

  This study is testing a new device to see if it can help people with severe pulmonary arterial hypertension live longer and avoid hospital visits.

  Recruiting Shanghai Zhongshan Hospital · Shanghai, Shanghai Municipality · NCT06605794

• Using empagliflozin to treat pulmonary arterial hypertension

  This study is testing if a medication called empagliflozin can help people with pulmonary arterial hypertension feel better by lowering their blood pressure in the lungs and improving heart function.

  Recruiting Phase 1 China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT06554301

• Mobile health program to boost exercise in teens with pulmonary arterial hypertension

  This study is testing a mobile health program to see if it can help teenagers with pulmonary arterial hypertension get more exercise.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT06549452

• Using breath analysis to identify multiple lung diseases

  This study is testing if analyzing breath samples can help identify different lung diseases like lung cancer and COPD in a large group of 10,000 people.

  Recruiting ChromX Health · Guangzhou, Guangdong · NCT06528418

• Registry for patients with fibrotic interstitial lung disease in Taiwan

  This study is collecting health information from patients with fibrotic interstitial lung disease in Taiwan to see how they do over time and how well different treatments work.

  Recruiting Taichung Veterans General Hospital · Taichung · NCT06476470

• Evaluating exercise capacity and muscle function in children with pulmonary arterial hypertension

  This study is testing how pulmonary arterial hypertension affects exercise and muscle function in children by comparing them to healthy kids.

  Recruiting Gazi University · Ankara, Çankaya · NCT06454838

• 129Xe MRI to monitor sotatercept treatment in pulmonary arterial hypertension

  This will test whether hyperpolarized 129Xe MRI scans can noninvasively track lung blood-vessel improvement in adults with pulmonary arterial hypertension treated with sotatercept.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06351345

• Evaluating safety of preservative-free treprostinil in children with pulmonary arterial hypertension

  This study is testing whether a new preservative-free version of treprostinil is safe for children with pulmonary arterial hypertension.

  Recruiting at 5 sites Phase 3 AOP Orphan Pharmaceuticals AG · Vienna, State of Vienna and 4 other locations · NCT06350032

• Comparing triple therapy to double therapy for pulmonary arterial hypertension

  This study is testing if a new combination of three medications can help adults with severe pulmonary arterial hypertension feel better compared to the usual two-medication treatment.

  Recruiting at 3 sites Phase 4 AOP Orphan Pharmaceuticals AG · Bahía Blanca and 27 other locations · NCT06317805

• Long-term evaluation of seralutinib for pulmonary arterial hypertension

  This study is testing how well and safely a new inhaled medication called seralutinib works for adults with pulmonary arterial hypertension who have already tried it before.

  Recruiting at 99 sites Phase 3 Gossamer Bio USA, Inc. · Fresno, California and 119 other locations · NCT06274801

• Using 129Xe MRI to Diagnose and Monitor Pulmonary Arterial Hypertension

  This study is testing if a special type of MRI can help doctors spot different types of Pulmonary Arterial Hypertension and track how the disease changes over time in people with this condition.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06104228

• Using valsartan to help treat pulmonary hypertension

  This study is testing if the medication valsartan can help adults with pulmonary arterial hypertension feel better and improve their heart function.

  Recruiting Phase 2 University of Washington · Seattle, Washington · NCT06053580

• Registry of Pulmonary Arterial Hypertension Linked to Connective Tissue Diseases

  This study is collecting information from patients with pulmonary hypertension linked to connective tissue diseases to see how the condition progresses and improve treatment over five years.

  Recruiting Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran · Mexico City · NCT05665556

• Evaluating Sotatercept in Children with Pulmonary Arterial Hypertension

  This study is testing a new drug called sotatercept in children with pulmonary arterial hypertension to see how well they tolerate it and how it affects their condition.

  Recruiting at 34 sites Phase 2 Merck Sharp & Dohme LLC · Los Angeles, California and 34 other locations · NCT05587712

• Using artificial intelligence to evaluate pulmonary hypertension

  This study is testing if using artificial intelligence with different medical tests can help doctors find pulmonary hypertension earlier and more accurately in patients.

  Recruiting Chinese Pulmonary Vascular Disease Research Group · Beijing, Beijing Municipality · NCT05566002

• Mobile health intervention for patients with pulmonary arterial hypertension

  This study is testing whether a mobile health program using smart texts can help people with pulmonary arterial hypertension feel better and move more compared to regular care.

  Recruiting Vanderbilt University Medical Center · Nashville, Tennessee · NCT05464095

• Using PET imaging to detect early pulmonary arterial hypertension

  This study is testing a new imaging method to see if it can help detect early signs of pulmonary arterial hypertension in patients before it gets worse.

  Recruiting Early Phase 1 University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05452889

• Registry and cohort study of pulmonary vascular disease

  This study looks at patients with pulmonary hypertension to understand their causes, treatments, and outcomes while building a system to collect and share this information for better future care.

  Recruiting at 13 sites Nanjing First Hospital, Nanjing Medical University · Guangzhou, Guangdong and 12 other locations · NCT05368467

• Using Xenon MRI to study pulmonary hypertension

  This study is testing if a special type of MRI can help understand how lung changes in people with pulmonary arterial hypertension affect their breathing and overall health.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT04991454

• Registry and biorepository for pulmonary hypertension patients

  This study is setting up a collection of health information and blood samples from people with pulmonary hypertension to help researchers learn more about the disease and improve treatments.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT04808596

• Identifying lung disease signatures using advanced MRI techniques

  This study is testing a new MRI technique to see if it can help identify which patients with pulmonary hypertension might benefit from specific treatments.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT04778046

• Treatment for pulmonary arterial hypertension using a new device

  This study is testing a new device to see if it can safely help people with pulmonary hypertension and right heart problems feel better.

  Recruiting at 9 sites Aria CV, Inc · La Jolla, California and 11 other locations · NCT04555161

• Understanding how drugs work in children

  This study is trying to find the best and safest doses of certain medications for children and young adults under 21 who are being treated for conditions like COVID-19 and pulmonary arterial hypertension.

  Recruiting at 5 sites Duke University · Phoenix, Arizona and 51 other locations · NCT04278404

• Registry for patients with pulmonary hypertension

  This study collects information from people with pulmonary hypertension to see how they are diagnosed and treated, and to find ways to improve their care.

  Recruiting at 51 sites Pulmonary Hypertension Association, Inc. · Phoenix, Arizona and 51 other locations · NCT04071327

• Evaluating the effects of two drugs on heart function in patients with advanced pulmonary arterial hypertension

  This study is testing if a combination of two heart medications can improve heart function more than just one medication in people with advanced pulmonary arterial hypertension.

  Recruiting Phase 3 University of Arizona · Tucson, Arizona · NCT04062565

• Registry of pulmonary hypertension in Poland

  This study is tracking patients with pulmonary hypertension in Poland to see how their condition is managed and what outcomes they experience.

  Recruiting Polish Cardiology Association · Krakow · NCT03959748

• Identifying genetic factors for pulmonary arterial hypertension in congenital heart defects

  This study is trying to find out if certain gene changes in people with congenital heart defects can lead to pulmonary arterial hypertension, to help catch and treat it earlier.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven · NCT02691689

• Registry for children with pulmonary hypertension

  This study is collecting information about children with pulmonary hypertension to better understand the condition and improve treatment options for them.

  Recruiting at 12 sites New York Medical College · Palo Alto, California and 13 other locations · NCT02249923

• Using spironolactone to treat pulmonary arterial hypertension

  This study is testing if the medication spironolactone can help adults with pulmonary arterial hypertension by improving their blood vessel function and reducing inflammation.

  Recruiting Phase 2 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT01712620

NIH-funded research (newest 40 of 97)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how blood flow and pressure affect lungs in PAH

  This grant studies how abnormal blood flow and pressure contribute to pulmonary arterial hypertension and how patient factors shape these effects, with the aim of guiding better therapies.

  NIH research University of Washington · Seattle, United States · NIH-11531183

• Asporin as a double-targeted therapy and biomarker for a serious artery disease

  This project tests a protein called asporin as both a treatment and a biomarker for pulmonary arterial hypertension (PAH) to help people with this life-threatening condition.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11450594

• Platelets and fibroblasts linked to energy use in a hard-to-treat blood vessel disease

  A research team at the University of Pittsburgh is studying how platelet energy metabolism and fibroblast glutamine use interact in systemic sclerosis-related pulmonary arterial hypertension to improve diagnosis and treatment.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11419895

• A biatrial dual‑lumen catheter to help the heart and lungs in pulmonary arterial hypertension

  A new double‑lumen catheter is being developed to unload the right side of the heart and protect the lungs for people with pulmonary arterial hypertension.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11418121

• Endothelial inflammation and Src kinase in early pulmonary arterial hypertension

  Researchers are studying how inflammation in the lining of blood vessels and a protein called Src kinase contribute to early lung artery remodeling in people with mild PAH.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11411210

• Cardiopulmonary chip model to study right heart disease from high blood pressure in the lungs

  A tiny heart-lung chip is being developed to understand why the right side of the heart enlarges in people with pulmonary arterial hypertension and to test targeted treatments.

  NIH research Medluidics LLC · Elk Grove, United States · NIH-11410451

• Empagliflozin to Improve Right Ventricular Function in Pulmonary Arterial Hypertension

  A 3-center, placebo-controlled study tests whether daily 10 mg empagliflozin for 24 weeks can help heart function and other outcomes in people with PAH.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11399092

• Empagliflozin to Help the Right Heart in PAH

  A patient-focused trial will test whether empagliflozin can improve the right heart’s function in people with pulmonary arterial hypertension.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11398874

• Move PAH: a mobile health program to boost daily activity and quality of life for people with pulmonary arterial hypertension

  A smartphone-based program uses text messages and activity data to help people with PAH be more active and feel better.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11396552

• Kynurenine pathway in pulmonary arterial hypertension and its impact on lung blood vessels

  A Johns Hopkins-led study will explore how a body chemistry pathway called kynurenine might drive changes in the lungs of people with pulmonary arterial hypertension (PAH).

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11396550

• RASA3 gene role in pulmonary arterial hypertension

  A scientist will study how the RASA3 gene affects cells in pulmonary arteries to understand a severe lung condition called PAH.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11396286

• Integrative multiomics to find genes and networks in PAH

  This NIH grant supports a clinician-scientist at UCLA to map genes and networks involved in pulmonary arterial hypertension using cutting-edge multiomics.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11393638

• Endothelial and smooth muscle cell programs in pulmonary arterial hypertension

  A study in mice will map how genes in lung blood vessel cells influence pulmonary arterial hypertension and identify factors that might protect against or worsen the disease.

  NIH research Stanford University · Stanford, United States · NIH-11391267

• Understanding right heart fat in PAH and how it affects function

  This NIH grant studies why the right side of the heart accumulates fat in people with pulmonary arterial hypertension and how that affects exercise and heart failure.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11385327

• Biatrial catheter to support the heart and lungs in pulmonary arterial hypertension

  A small, patient-friendly device is being developed to temporarily support the heart and lungs in people with pulmonary arterial hypertension.

  NIH research Sentara Health · Virginia Beach, United States · NIH-11384970

• Carnitine supplementation for the heart’s right side in PAH

  This project tests whether taking carnitine can help improve heart function and quality of life for people with pulmonary arterial hypertension.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11370500

• One versus two medicines for children with pulmonary arterial hypertension

  This compares starting one medicine versus starting two medicines for children with pulmonary arterial hypertension to find which approach helps symptoms, exercise ability, and heart health.

  NIH research Duke University · Durham, United States · NIH-11364147

• Single versus combination oral treatment for children with pulmonary arterial hypertension

  This project compares starting one oral PAH medicine versus starting two (sildenafil plus bosentan) right away in children with pulmonary arterial hypertension to see which approach better helps breathing, heart function, and daily life.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11364094

• Identifying somatic mutations linked to pulmonary arterial hypertension

  A patient-facing study exploring whether somatic mutations in lung blood vessel pathways contribute to PAH, potentially revealing new clues for diagnosis or treatment.

  NIH research University of Washington · Seattle, United States · NIH-11363395

• Gut Restore-PAH: Microbiota Transplant to Help Pulmonary Angiopathy

  A small pilot study will test whether transplanting healthy gut bacteria, with antibiotics beforehand and fiber support, can help people with pulmonary arterial hypertension.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11354274

• Systemic consequences of PAH on lean muscle mass in PAH patients

  This project looks at why people with pulmonary arterial hypertension lose muscle mass and how that affects their health and daily life.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11345642

• Revumenib as an epigenetic treatment for pulmonary arterial hypertension

  This project looks at whether the drug revumenib can reverse harmful cell changes that narrow lung arteries in people with pulmonary arterial hypertension.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11338930

• Role of CES1 in lung blood vessel health and PAH biology

  This NIH grant explores how a liver enzyme, CES1, helps lung blood vessels stay healthy and may drive pulmonary arterial hypertension in people.

  NIH research Stanford University · Stanford, United States · NIH-11332306

• Vps34 in Pulmonary Hypertension: A Pathway to Safer, Stronger Lungs

  Aims to understand how a cellular pathway (Vps34) drives abnormal blood vessel remodeling in pulmonary hypertension and test strategies to slow or stop this process.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11331310

• Targeting FAK-NEDD9 to slow PAH-related vessel remodeling

  A new approach aims to block a key protein interaction in the lungs to slow blood vessel remodeling in pulmonary arterial hypertension.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11324945

• NOTCH3 blood marker for pulmonary arterial hypertension

  This project looks for a NOTCH3 protein fragment in blood to help detect and monitor pulmonary arterial hypertension in people with PAH.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11310864

• Pulmonary hypertension risk in systemic sclerosis linked to a DNASE1L3 genetic variant

  A small study is looking at how a specific genetic change in DNASE1L3 might raise the risk of lung blood-vessel problems in people with systemic sclerosis.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11289756

• ARID1A and the gene 'switches' that shape pulmonary arterial hypertension

  This project looks at whether changes in the ARID1A gene and related epigenetic switches drive the blood-vessel scarring that causes pulmonary arterial hypertension.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11289363

• Investigating a protein's role in lung blood vessel disease

  This study is looking at how a protein called Vps34 affects the growth of certain cells in the lungs of people with pulmonary arterial hypertension (PAH), with the hope of finding new ways to treat this serious condition.

  NIH research State University of Ny,binghamton · Binghamton, United States · NIH-11269309

• HIPK2 and blood vessel remodeling in pulmonary arterial hypertension

  Researchers are testing whether blocking the HIPK2 protein can reduce the abnormal growth of lung artery muscle cells and help people with pulmonary arterial hypertension.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11261617

• Lung-targeted serotonin blocker for pulmonary arterial hypertension

  Developing lung-focused medicines that block a serotonin receptor to help people with pulmonary arterial hypertension.

  NIH research Vanderbilt University · Nashville, UNITED STATES · NIH-11261527

• How the right side of the heart uses energy in pulmonary arterial hypertension

  This project looks at how the right ventricle's blood flow and energy change over time in people with pulmonary arterial hypertension using a 3D echocardiogram technique.

  NIH research University of California-Irvine · Irvine, United States · NIH-11249689

• Pericytes' role in small blood-vessel changes in pulmonary arterial hypertension

  This project looks at whether malfunctioning pericytes — the cells that support tiny lung blood vessels — drive harmful vessel remodeling in people with pulmonary arterial hypertension.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11247521

• Lactate and LDHA in pulmonary arterial hypertension

  This work looks at how excess lactate made by artery cells may drive thickening of lung blood vessels in people with pulmonary arterial hypertension.

  NIH research University of California at Davis · Davis, United States · NIH-11235916

• Investigating how ion channels and membrane receptors affect pulmonary arterial hypertension

  This study is looking into how certain proteins and channels in the blood vessels of the lungs might cause problems for people with pulmonary arterial hypertension (PAH), with the goal of finding new ways to help improve their health.

  NIH research University of Florida · Gainesville, United States · NIH-11228445

• Empagliflozin for right heart function in pulmonary arterial hypertension

  This project will see if empagliflozin, a diabetes drug, can help the right side of the heart work better in people with pulmonary arterial hypertension.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11199033

• Understanding physical activity patterns in patients with pulmonary arterial hypertension.

  This study looks at how staying active impacts people with pulmonary arterial hypertension (PAH) by using special devices to track their daily movements, with the goal of creating personalized exercise plans that can help improve their health and well-being.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11194972

• Oral medicine to slow damage from pulmonary arterial hypertension

  A new oral drug called VN-1032 aims to slow blood-vessel damage in people with pulmonary arterial hypertension.

  NIH research Vasculonics, LLC · Indianapolis, United States · NIH-11193989

• Platelet and lung vessel cell metabolism in scleroderma-related pulmonary hypertension

  This project looks at whether energy changes in platelets signal lung vessel cells to change glutamine use and worsen pulmonary hypertension in people with systemic sclerosis.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11193267

• Understanding Muscle Loss in Pulmonary Arterial Hypertension

  This project aims to understand why people with pulmonary arterial hypertension (PAH) often lose muscle mass and how this affects their health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11192240

Related topics

Quick answers

How many Pulmonary Arterial Hypertension clinical trials are recruiting right now?

49, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 42 countries. The most sites are in United States (25 trials), Spain (6 trials), China (6 trials), United Kingdom (6 trials), France (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 11, Phase 3: 6, Phase 4: 3, Phase 1/2: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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