Examining the link between kidney function and biomarkers in pulmonary hypertension

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the relationship between urinary and plasma biomarkers and changes in estimated glomerular filtration rate (eGFR) in patients with pulmonary hypertension (PH). Given that kidney disease is prevalent in approximately 35% of PH patients and is associated with worse outcomes, understanding the mechanisms connecting heart and kidney function is crucial. The study will involve inpatients aged 18 and older who are undergoing right heart catheterization, without any planned interventions. By identifying potential biomarkers, the research seeks to enhance diagnostic and prognostic capabilities for kidney disease in the context of PH.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Inpatients aged ≥18 years
* Undergoing right heart catheterization (RHC)

Exclusion Criteria:

* multifactorial or indeterminate PH, for which no single underlying mechanism could be reliably classified
* active tumor disease requiring targeted therapy
* inflammatory or autoimmune disease with renal involvement requiring systemic immunosuppressive treatment
* unexplained kidney function decline, defined as serum creatinine increase ≥0.5 mg/dL from baseline within the prior 7 days before RHC
* Chronic kidney disease with eGFR \<20 ml/min/1.73 m2
* non-kidney failure requiring extracorporeal or peritoneal ultrafiltration for diuretic-resistant volume overload
* if they had received non-steroidal anti-inflammatory drugs or intravenous contrast within 72 hours before RHC
* prediagnosed glomerulonephritis
* polycystic kidney disease
* postrenal obstruction
* single kidney (functional or anatomical)
* solid organ transplantation
* anticipated life expectancy of \<12 months
* likelihood of receiving advanced therapy (mechanical circulatory assist device/lung or cardiac transplant)
* pregnancy or possibility of pregnancy in the next 12 months
* inability to cooperate with respiratory maneuvers during renal Doppler
* refusal to participate
* not available for follow-up visits

Where it's running

• Kerckhoff Klinik Heart and Thorax Center
  Bad Nauheim, Hesse, Germany Recruiting
• University Hospital Giessen and Marburg, Campus Giessen, Department of Internal Medicine II
  Giessen, Hesse, Germany Recruiting

Study contacts

• Principal investigator: Faeq Husain-Syed, MD — University of Giessen
• Study coordinator: Faeq Husain-Syed, MD
• Email: faeq.husain-syed@innere.med.uni-giessen.de
• Phone: +49 641 985 42378

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.