Understanding postpartum pulmonary artery pressure in women with preeclampsia and antiphospholipid syndrome

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate postpartum pulmonary artery pressure in women who experienced preeclampsia during pregnancy, particularly focusing on those with antiphospholipid syndrome. Participants will be monitored for up to three years after childbirth to assess the long-term cardiovascular effects of these conditions. The study involves clinical examinations, echocardiography, blood sampling, and 24-hour ambulatory blood pressure monitoring to gather comprehensive data on the participants' health. This research represents a unique cohort in Switzerland, providing valuable insights into the intersection of these serious pregnancy complications and their long-term impacts.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age: \> 16 years.
* Consent or waiver of consent according Chapter 9
* Preeclampsia

Defined as:

• New onset hypertension (blood pressure \>140/90mmHg on multiple occasions after 20 weeks of gestation)

In combination with new onset of 1 or more of the following:

* Proteinuria (urine protein \>300mg /24h or 2+ or higher in dipstick on multiple occasions)
* Platelet count \<100,000/microL,
* Serum creatinine \>97.2 micromol/L,
* Liver transaminases at least twice the upper limit of the normal concentrations,
* Pulmonary edema,
* New-onset and persistent headache,
* Visual symptoms. -Postnatal follow up at the obstetrical and cardiology clinic, Inselspital Bern, Switzerland.

Exclusion Criteria:

* Age: \< 16 years
* Incomplete or ambiguous data: if data confirming the eligibility criteria or data to analyze the primary endpoint is not fully available or despite efforts assessed as significantly ambiguous, the data set will be excluded from analyses, since no analysis is possible

Where it's running

• Inselspital
  Bern, Switzerland Recruiting

Study contacts

• Principal investigator: Emrush Rexhaj, MD — Insel Gruppe AG, Inselspital, Bern
• Study coordinator: Emrush Rexhaj, MD
• Email: emrush.rexhaj@insel.ch
• Phone: +41 31 632 21 11

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.