TEMPO-PH: How the right heart adapts in pulmonary hypertension over time
Official title: TEMPO-PH (Temporal Evolution and Multi-omic Profiles in Pulmonary Hypertension)
Funded at University of Washington · NIH-11463807 · Data updated 2026-11-12
A study to build a detailed molecular portrait of why the right side of the heart fails in pulmonary hypertension and how a common heart medicine might help.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 7, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $773,815 |
| NIH project number | 1R01HL188754-01 |
| Project ID | NIH-11463807 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with pulmonary arterial hypertension who participated in the REVAMP-PH trial and consented to further molecular analyses.
✕Less likely to help
People not eligible for or not willing to provide biological samples or participate in follow-up analyses.
What this research studies
This project will profile participants from a prior PAH trial to create a comprehensive map of blood and tissue-based markers over time. By combining multi-omics and extracellular vesicle analyses, researchers will explore how blocking the angiotensin receptor could influence the right heart’s response to pressure overload. The goal is to uncover biological clues that explain RV vulnerability and identify potential targets for therapy beyond reducing lung pressures. The study leverages existing trial participants and deep clinical data to generate insights that could guide new treatments for PAH and related heart-lavor diseases.
Why it matters
Potential benefit: If successful, the work could reveal molecular targets and pathways that support the right ventricle, informing future therapies.
How similar studies have gone: Previous multi-omic profiling in PAH has yielded meaningful biological insights, but this project advances by linking profiling with a RAAS-focused therapeutic hypothesis.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Leary, Peter J — University of Washington
- Study coordinator: Leary, Peter J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.