Using Toradol for Pain Control After Prophylactic Femoral Nailing

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of using Toradol (ketorolac) in addition to opioids for post-operative pain management in patients undergoing prophylactic intramedullary nailing of the femur due to bone lesions. It aims to address the opioid crisis by exploring a multi-modal pain management approach that may reduce reliance on narcotics. The study will compare pain control outcomes between patients receiving both Toradol and opioids versus those receiving only opioids. The unique patient population consists of individuals without fractures, allowing for the safe use of NSAIDs post-operatively.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Femoral Shaft or Neck bone lesion
2. 18 years old or greater
3. Plan to undergo prophylactic intramedullary nailing of one femur

Exclusion Criteria:

1. Concurrent pathologic fracture
2. History of advanced renal impairment (eGFR\<30mL/min)
3. History of Peptic Ulcer Disease with bleeding or requiring hospitalization
4. History of NSAID or aspirin allergy
5. Concurrent chemotherapy regimen that prevents NSAID use
6. History of liver disease that precludes use of toradol
7. History of heart failure or cardiovascular disease that precludes toradol usage
8. Pregnancy
9. History of narcotic allergy resulting in anaphylaxis
10. Patients with coagulation disorders or those who require concomitant use of anticoagulant or anti- platelet therapy during the treatment phase of the study.
11. Patients with acetaminophen allergies resulting in anaphylaxis
12. Current use of the medication probenecid
13. Current use of the medication Pentoxifylline
14. History of aspirin induced asthma.
15. Known history of opioid dependence, abuse, or addiction.
16. Bilateral IMN of the femurs

Where it's running

• Saint Louis University
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: David Greenberg, MD — St. Louis University
• Study coordinator: David Greenberg, MD
• Email: david.greenberg@health.slu.edu
• Phone: 314-617-3410

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.