Condition

Pain, Chronic clinical trials and research

• 39Clinical trials
• 13Countries

Newest Pain, Chronic clinical trials

All recruiting trials (39)

• Therapeutic yoga and interoceptive awareness in adolescents with chronic pain

  This will test whether an occupational therapy plan that includes therapeutic yoga helps adolescents (ages 11–21) with chronic pain improve body awareness and day-to-day function.

  Recruiting Connecticut Children's Medical Center · Hartford, Connecticut · NCT07325110

• Butyrate and Taurine for Chronic Postoperative Pain in Adults after Cardiac Surgery

  This study tests whether taking taurine and butyrate daily can reduce long-lasting pain after cardiac surgery in adults.

  Recruiting Chinese University of Hong Kong · Hong Kong · NCT07144033

• VMD-3866 topical gel for chemotherapy-induced nerve pain

  This trial will test whether a non-opioid topical gel called VMD-3866 can reduce pain in adults with chemotherapy-induced peripheral neuropathy.

  Recruiting Phase 2 VM Therapeutics LLC · London, UK · NCT07072468

• Home-based ear (taVNS) stimulation for IBS pain

  This trial will test whether a home-based ear vagus nerve stimulation device, used twice daily for six weeks, helps reduce pain and symptoms in 18–29-year-olds with IBS compared with a look‑alike sham device.

  Recruiting Yale University · New Haven, Connecticut · NCT06847360

• Effects of prescription opioids on brain structure and cognition in older adults with chronic pain

  This study is testing how taking prescription opioids affects the brain and thinking skills in older adults with chronic pain.

  Recruiting Phase 2 Mayo Clinic · Rochester, Minnesota · NCT06837857

• Pain Reprocessing Therapy for persistent knee pain after knee replacement

  This trial will test whether Pain Reprocessing Therapy (PRT) delivered by video can reduce persistent knee pain in adults who still have meaningful pain three months after knee replacement.

  Recruiting Phase 2 Weill Medical College of Cornell University · Aurora, Colorado and 1 other locations · NCT06800209

• Using ziconotide for treating severe chronic pain not related to cancer

  This study is trying to see if ziconotide can safely help people with severe chronic pain that isn't related to cancer.

  Recruiting at 9 sites ESTEVE Pharmaceuticals SAS · Aubagne and 13 other locations · NCT06541184

• Understanding chronic pain after heart surgery

  This study looks at what causes long-lasting pain in people aged 18-80 after heart surgery to help improve pain management for these patients.

  Recruiting Ankara Etlik City Hospital · Ankara, Ankara and 1 other locations · NCT06534372

• Culturally tailored pain management for Black elders

  This study is testing a new pain management program designed specifically for Black elders with chronic pain to see if it helps them feel better and manage their pain more effectively.

  Recruiting University of Florida · Gainesville, Florida · NCT06512727

• National Registry for Artery Embolization to Treat Chronic Pain

  This study is testing if a procedure that blocks blood flow to painful areas can help people with chronic pain from osteoarthritis and other conditions feel better.

  Recruiting at 2 sites Vascular Solutions of North Carolina · Cary, North Carolina and 1 other locations · NCT06477965

• Cognitive behavioral therapy for long-term pain in rheumatic diseases

  This study is testing whether cognitive behavioral therapy can help people with long-term pain from rheumatic diseases manage their pain better.

  Recruiting Diakonhjemmet Hospital · Oslo, Oslo · NCT06413914

• Opioid-free anesthesia for breast cancer surgery

  This study tests whether using opioid-free anesthesia during breast cancer surgery can help patients recover better and have fewer side effects compared to traditional anesthesia.

  Recruiting University of Ioannina · Ioannina, Epirus · NCT06404983

• Impact of Targeted Physical Activity on Dialysis Patients

  This study is testing if a personalized exercise program can help people on dialysis or with severe kidney disease feel better and improve their health over a year.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT06374537

• Improving sleep quality for patients with chronic pain

  This study is testing a new group program to help adults with chronic pain sleep better and see if it can also ease their pain compared to standard treatments.

  Recruiting University of Tromso · Tromsø, Troms County · NCT06351839

• Examining opioid use in adolescents after surgery

  This study looks at how surgery-related opioid use affects teenagers aged 12-17 and aims to find out what factors might lead to opioid use disorder after their surgery.

  Recruiting Boston Children's Hospital · Aurora, Colorado and 4 other locations · NCT06350409

• Using virtual reality to reduce pain during knee procedures

  This study tests if using virtual reality can help reduce pain and improve satisfaction for patients getting knee procedures compared to just sedation alone.

  Recruiting Northwestern University · Chicago, Illinois · NCT06336447

• Nutrition care for patients with chronic pain

  This study is testing a new app that helps people with chronic pain improve their nutrition and overall health through a personalized program.

  Recruiting Linkoeping University · Linköping, Östergötland County · NCT06277232

• Using Stellate Ganglion Block to Prevent Depression After Mastectomy

  This study tests whether a special nerve block can help prevent depression and pain in women who are having surgery for breast cancer.

  Recruiting Mansoura University · Al Mansurah · NCT06263907

• Effects of CBD on chronic pain in veterans

  This study tests whether CBD can help veterans with chronic pain feel better compared to a placebo.

  Recruiting Phase 2 University of Michigan · Ann Arbor, Michigan · NCT06213233

• Evaluating a toolkit to help caregivers identify and communicate pain in dementia patients

  This study is testing a new toolkit to help caregivers of people with dementia recognize and talk about pain to see if it makes a difference in their care.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT06168604

• Evaluating sensation and satisfaction in cancer and transgender mastectomy patients

  This study is testing if advanced surgical techniques can improve sensation and satisfaction for people undergoing gender-affirming mastectomy and breast reconstruction.

  Recruiting at 2 sites Weill Medical College of Cornell University · Boston, Massachusetts and 1 other locations · NCT06094257

• Translating and validating a questionnaire for opioid misuse in Swedish pain patients

  This study is testing a new Swedish questionnaire to see if it can help identify opioid misuse among pain patients who are using opioids for treatment.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06084520

• Monitoring methadone levels using a wearable device

  This study is testing a new wearable device that tracks methadone levels in people with chronic pain to see how well it helps monitor their medication use.

  Recruiting Cari Health Inc. · Lemon Grove, California · NCT05981573

• Examining pain relief mechanisms after lumbar nerve blocks

  This study is testing how well lumbar nerve blocks can relieve chronic low back pain and how the body's nervous system affects that relief in patients who are about to receive the treatment.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05961800

• Documenting opioid use and pain management after surgery

  This study looks at how opioids are used for pain management after surgery in adults to see how it affects their recovery and quality of life over time.

  Recruiting University of Aberdeen · Zagreb, Vinogradska 29 and 3 other locations · NCT05877157

• Freezing Nerves to Relieve Pain from Rib Fractures

  This study is testing if freezing the nerves can help people with rib fractures feel less pain compared to a fake treatment.

  Recruiting Sunnybrook Health Sciences Centre · Toronto, Ontario · NCT05865327

• Targeting abnormal blood flow to treat chronic joint pain in veterans

  This study is testing if treating abnormal blood flow in the joints can help veterans with chronic pain and osteoarthritis feel better.

  Recruiting Palo Alto Veterans Institute for Research · Palo Alto, California · NCT05700682

• Using advanced MRI to understand how Filgotinib relieves pain in rheumatoid arthritis

  This study is testing how Filgotinib helps relieve pain in people with rheumatoid arthritis by looking at brain activity and inflammation.

  Recruiting NHS Greater Glasgow and Clyde · Glasgow · NCT05697159

• Pain relief options for patients with schwannomatosis

  This study is testing different new treatments to see if they can help people with schwannomatosis manage their moderate-to-severe pain better.

  Recruiting Phase 2 Massachusetts General Hospital · Boston, Massachusetts · NCT05684692

• Exploring sleep and pain management in adolescents with chronic pain

  This study is testing whether a relaxation technique before bed can help teenagers with chronic pain sleep better and feel less pain.

  Recruiting Helsinki University Central Hospital · Helsinki · NCT05677412

• Comparing online cognitive behavioral therapy and a single session pain relief intervention for chronic pain

  This study is testing whether an 8-session online therapy program or a one-time pain relief session works better for people with chronic pain, like those with lupus or pelvic pain.

  Recruiting at 3 sites Stanford University · Phoenix, Arizona and 4 other locations · NCT05612750

• Predicting and understanding pain six months after radiotherapy for head and neck cancer

  This project will see if people treated with radiotherapy for head and neck cancer who still have pain at six months are more likely to keep smoking or drinking, be depressed, feel very tired, or have worse overall quality of life.

  Recruiting University Hospital, Caen · Caen · NCT05505188

• iCanCope PostOp app to help teens manage pain after scoliosis or pectus surgery

  This project will test whether the iCanCope PostOp smartphone app helps teens aged 12–18 manage pain and recovery after scoliosis or minimally invasive pectus surgery.

  Recruiting The Hospital for Sick Children · Boston, Massachusetts and 1 other locations · NCT05382962

• Reducing post-mastectomy pain with opioid-free anesthesia

  This study is testing whether using anesthesia without opioids can help women who have had a mastectomy experience less chronic pain a year after their surgery compared to traditional opioid-based anesthesia.

  Recruiting Gangnam Severance Hospital · Seoul · NCT05146778

• Assessing the effects of spinal cord stimulators on diabetic neuropathy

  This study is testing if spinal cord stimulators can help people with diabetes and painful nerve damage feel better and improve their overall health.

  Recruiting University of Chicago · Chicago, Illinois · NCT04687215

• Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking

  This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04439552

• Tracking pain and related outcomes using technology

  This study is testing a new mobile app designed to help people with chronic pain track their symptoms and medications to see if it can improve their self-management.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT04267588

• Treatment for obesity and chronic pain in adolescents

  This study is testing a new approach that combines pain education and treatment with weight management to help teenagers who are dealing with both obesity and chronic pain.

  Recruiting Connecticut Children's Medical Center · Hartford, Connecticut · NCT04046562

• Telephone-based support program for seniors with mental health issues

  This study tests a phone support program to help seniors in Pennsylvania with mental health issues who are starting new medications, to see if it improves their care and outcomes.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT02463266

Related topics

Quick answers

How many Pain, Chronic clinical trials are recruiting right now?

39, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (23 trials), United Kingdom (3 trials), Sweden (2 trials), Canada (2 trials), France (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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