Condition

Substance Use Disorders clinical trials and research

• 58Clinical trials
• 110NIH research projects
• 9Countries

Newest Substance Use Disorders clinical trials

All recruiting trials (58)

• Interprofessional Training to Improve Care for Peri-Delivery Patients with Substance Use Disorder

  This program tests INSPIRE, a set of online and in-person trainings for healthcare teams to reduce stigma and improve care for people with substance use disorder around labor, delivery, and postpartum at the University of Utah.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07707115

• Effects of comorbidity on people with severe mental illness

  This study tests how having both alcohol/substance use and a severe mental illness affects hospitalizations, medications, and social participation among adults followed at a mental health center.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07692984

• Interdisciplinary support to smooth care transitions for hospitalized adults with substance use disorders

  This study tests a team-based in-hospital and post-discharge program to help adults with substance use disorders move from hospital care to ongoing community treatment.

  Recruiting University of Utah · Salt Lake City, Utah · NCT07575373

• Maintaining Independence and Sobriety through Systems Integration, Outreach, and Networking-Criminal Justice (MISSION-CJ) for re-entry

  This trial tests a multicomponent program called MISSION-CJ with Peer Linkage Support to help adults released from two Massachusetts jails who have both mental health and substance use disorders.

  Recruiting at 2 sites University of Massachusetts, Worcester · Northampton, Massachusetts and 1 other locations · NCT07555145

• Helping toddlers of caregivers with substance use disorders build language skills with group and individualized parenting supports

  This project will test whether adding coaching and one-on-one lessons to a group parenting program helps toddlers (12–42 months) of caregivers with substance use disorders develop better language skills.

  Recruiting University of Oregon · Eugene, Oregon · NCT07529327

• Recovery Inspired Support Engagement: A 12‑week 1-on-1 program for families and friends supporting someone in recovery

  A 12‑week telehealth program will test whether a one‑on‑one support program for people who support loved ones in substance use recovery is doable and acceptable.

  Recruiting Mclean Hospital · Belmont, Massachusetts · NCT07519759

• Weight-loss drug stoppage and restart effects on brain, mood, and daily life

  This study tests what happens to brain signals, mood, sleep, and daily functioning when a tirzepatide user pauses the medication and then restarts it.

  Recruiting The University of Texas at Dallas · Dallas, Texas · NCT07387796

• SoundHeal multi-sensory integrative therapy for detained youth with emotional dysregulation

  This program will test whether SoundHeal's multi-sensory therapy can help detained youth (ages 12–18) better manage emotional dysregulation, depression, anxiety, and stress.

  Recruiting SoundHeal · San Luis Obispo, California · NCT07364799

• Brain imaging to predict teens' response to cannabis treatment

  This project will test whether teens' brain activity during a learning task can predict how well 14–17-year-olds do in a 10-week virtual reward program to reduce cannabis use.

  Recruiting Indiana University · Indianapolis, Indiana · NCT07340554

• Using regular client feedback (FIT) to improve outcomes in social services

  This project will test whether using regular client feedback with FIT helps people receiving social services—such as outpatient, addiction, and residential care—get better, more tailored support.

  Recruiting Karolinska Institutet · Linköping · NCT07303608

• Transcutaneous auricular neurostimulation (tAN) for reducing alcohol withdrawal in people with alcohol use disorder

  This trial will try a five-day ear‑stimulation device (tAN) versus a sham device to reduce alcohol withdrawal symptoms in adults with moderate-to-severe alcohol use disorder.

  Recruiting Spark Biomedical, Inc. · Houston, Texas · NCT07281261

• Improving supervision in addiction treatment programs

  This project will try a reinforcement-based supervision approach with supervisors and counselors at residential addiction treatment programs to see if it reduces counselor burnout and improves care for clients.

  Recruiting University of Arkansas · Little Rock, Arkansas · NCT07262372

• Impact of MOUD Policy Changes During the Pandemic on Opioid and Alcohol Use Disorders

  This study tests how federal and state policy changes during the COVID-19 pandemic affected access to and use of medications for opioid use disorder among Veterans with opioid or alcohol use disorders.

  Recruiting Boston University · Boston, Massachusetts · NCT07232641

• Shared decision-making to prevent or treat HIV for people with recent justice involvement

  This project tests whether offering a shared decision-making 'patient choice' menu alongside standard patient navigation helps people with recent justice involvement start HIV prevention (PrEP) or treatment (ART) and begin substance use disorder care.

  Recruiting at 4 sites Yale University · New Haven, Connecticut and 3 other locations · NCT07223398

• Behavioral Activation delivered by peer recovery specialists in a community clinic

  This project will test whether Behavioral Activation delivered by peer recovery specialists helps adults with depression (and co-occurring substance use disorders) who receive care at a community behavioral health center.

  Recruiting Wayne State University · Detroit, Michigan · NCT07219394

• Safe & Sound Protocol as an add-on for adults with trauma and substance use disorders

  This study tests whether using the Safe and Sound Protocol as an extra treatment alongside usual care helps adults with trauma and substance use disorders.

  Recruiting Caron Treatment Centers · Wernersville, Pennsylvania · NCT07219056

• Kratom and other substances safety in people with past opioid use

  This study tests kratom at different doses against a placebo and oxycodone to see how people with a history of opioid use tolerate and respond to them.

  Recruiting Phase 1 Baylor College of Medicine · Houston, Texas · NCT07218549

• Temporal interference stimulation for nicotine vaping addiction

  This trial will test whether a non-invasive brain stimulation method called temporal interference can lower cravings and reduce vaping in adults who use nicotine.

  Recruiting at 2 sites Indiana University · Bloomington, Indiana and 1 other locations · NCT07210268

• ECCCLORE group program for people with addiction and trauma-related PTSD

  This program will try a group-based ECCCLORE therapy to see if it helps people who have addiction and PTSD or complex PTSD reduce substance use and impulsive or hostile behaviors.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Nîmes · NCT07193914

• Enhancing Addiction Treatment Through Psychoeducation

  A digital program tests whether neuroscience-based psychoeducation plus games can help people with opioid or stimulant use disorders who are on treatment to improve metacognition and treatment engagement.

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07178158

• An EMDR app for PTSD in people with substance dependence.

  This project will test whether an app-based autonomous EMDR program helps adults with PTSD who also have a substance use disorder.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT07146633

• A new digital training program for peer recovery supporters

  This project tests whether a fully online training platform, either alone or combined with live Zoom sessions, helps people training to be peer recovery supporters improve their knowledge, skills, and adherence compared with usual training.

  Recruiting Thrive Digital Health, LLC · Solon, Ohio · NCT07044531

• Using brain stimulation to reduce cravings and improve control in people with substance use disorders

  This study is testing if a type of brain stimulation can help people with alcohol use disorder feel less cravings and have better control during their detox treatment.

  Recruiting Central Institute of Mental Health, Mannheim · Mannheim and 1 other locations · NCT06959342

• E-cigarettes versus nicotine patches and lozenges to help people in substance-use treatment quit smoking

  This trial will test whether switching completely to e-cigarettes helps adults in outpatient substance use treatment quit smoking compared with using nicotine patches and lozenges.

  Recruiting at 4 sites Medical University of South Carolina · Charleston, South Carolina and 3 other locations · NCT06922617

• New blood test to help identify and track depression and early schizophrenia

  This project will try a new blood test to see if it can identify and track depression or early schizophrenia in adults receiving psychiatric care.

  Recruiting Fraser Health · New Westminster, British Columbia · NCT06856161

• Improving substance misuse prevention policy using research evidence

  This study is testing a new way to help state lawmakers use research to create better laws for preventing substance misuse.

  Recruiting Penn State University · University Park, Pennsylvania · NCT06856148

• Support for families grieving an overdose loss

  This project will test a peer-led grief support program called RIVER to help adults who lost a loved one to an unintentional drug overdose within the past year.

  Recruiting at 3 sites Rand · Birmingham, Alabama and 3 other locations · NCT06854757

• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• Improving self-efficacy to prevent mental disorders in young adults

  This study is testing if a special training program can boost confidence in young adults aged 18-30 to help prevent mental health issues like anxiety and substance use.

  Recruiting Health and Medical University Potsdam · Potsdam, Brandenburg · NCT06738953

• Understanding habits and decision-making in alcohol use disorder

  This study is trying to understand how habits and decision-making affect people with Alcohol Use Disorder compared to those without it.

  Recruiting Technische Universität Dresden · Dresden · NCT06701500

• Investigating how Pavlovian mechanisms influence substance use behaviors

  This study is testing how certain learned responses might affect substance use behaviors in people with moderate to severe substance use disorders compared to healthy individuals.

  Recruiting Technische Universität Dresden · Dresden · NCT06701487

• VR program to improve social functioning for people with substance use and mental health disorders

  This trial will try a virtual reality (VR) training program to see if it helps adults in long-term addiction treatment who also have mental health problems improve social and practical functioning.

  Recruiting at 2 sites Sykehuset Innlandet HF · Brumunddal and 1 other locations · NCT06677515

• Collaborative care program for young Black and Latino men at risk for HIV

  This study tests a new support program to help young Black and Latino men at risk for HIV start taking prevention medication and manage their substance use better.

  Recruiting Children's Hospital of Philadelphia · Baltimore, Maryland and 1 other locations · NCT06585631

• Family support program to help teens with depression or anxiety who are in substance use treatment

  This project will test whether adding a brief family support program (Fam-AID) to usual outpatient substance use care helps adolescents (ages 13–21) with depression or anxiety symptoms.

  Recruiting at 3 sites The National Center on Addiction and Substance Abuse at Columbia University · Chicago, Illinois and 2 other locations · NCT06413979

• HEAT telemedicine program for HIV and addiction care

  This project will try a telemedicine program to deliver addiction treatment to adults living with HIV in Alabama who report opioid or stimulant misuse.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT06370481

• Engagement of community health workers to support recovery from substance use disorders

  This study is testing whether support from community health workers can help people with substance use disorders engage better in treatment and improve their recovery experience after visiting the emergency department.

  Recruiting University of California, Los Angeles · Providence, Rhode Island · NCT06320015

• Prolonged Exposure Therapy for PTSD in Veterans with Substance Use Issues

  This study is testing if more frequent therapy sessions can help veterans with PTSD and substance use problems feel better compared to regular weekly sessions.

  Recruiting at 6 sites Veterans Medical Research Foundation · San Diego, California and 5 other locations · NCT06296186

• Early intervention for alcohol and substance abuse in adolescents

  This study is testing if an online program can help teenagers aged 14-20 at a psychiatric clinic reduce their alcohol and substance use by checking in with them before and after six months.

  Recruiting Kuopio University Hospital · Kuopio · NCT06262958

• One-year Parent-Child Assistance Program for parents with recent substance use

  This project will test whether a one-year Parent-Child Assistance Program helps parents who used substances during pregnancy stay with or reunify with their children and support their recovery.

  Recruiting at 2 sites University of Oklahoma · Enid, Oklahoma and 1 other locations · NCT06163651

• Using Battlefield Acupuncture to Help Veterans with Chronic Pain

  This study is testing if Battlefield Acupuncture can help veterans with chronic pain and a history of substance use feel better and improve their mood, stress, and sleep over eight weeks.

  Recruiting Edith Nourse Rogers Memorial Veterans Hospital · Bedford, Massachusetts · NCT06128772

• Syringe-service telemedicine plus social-network HIV prevention program

  This program will test whether training people who inject drugs to recruit and educate their peers through syringe service telemedicine and social networks increases HIV testing and use of prevention and treatment services in Maryland.

  Recruiting Johns Hopkins University · Baltimore, Maryland and 1 other locations · NCT06103370

• Digital RITch®CBT versus standard one-on-one CBT for men with substance use and partner aggression

  This trial will test whether a self-guided digital program called RITch®CBT helps men in addiction treatment who have recently shown aggression toward intimate partners, compared with standard one-on-one CBT.

  Recruiting University of Rochester · Rochester, New York · NCT05943171

• Helping MSM with HIV and substance use disorders overcome stigma and shame

  This study is testing a new program to help men who have sex with men and gender minorities living with HIV and substance use issues feel better about themselves and manage their health by reducing stigma and shame.

  Recruiting at 2 sites Boston University · Miami, Florida and 1 other locations · NCT05934305

• Intervention for pregnant women in jail with substance use issues

  This study is testing a new program for pregnant women in jail with substance use issues to see if it helps them reduce drug use and prevent substance-exposed pregnancies.

  Recruiting St. Louis University · St Louis, Missouri · NCT05854836

• Web-based training program for providers treating PTSD and substance use disorders

  This study is testing a new online training program for healthcare providers to help them better treat military Veterans who have both PTSD and substance use disorders.

  Recruiting VA Office of Research and Development · Charleston, South Carolina · NCT05812131

• Home treatment for severe addiction disorders

  This study tests if treating severe addiction at home can help people stay out of the hospital longer compared to traditional inpatient care.

  Recruiting University Hospital, Geneva · Geneva · NCT05563363

• Helping mothers with substance use issues during pregnancy

  This study is trying out a program to help mothers who have used drugs or alcohol during pregnancy get support and resources to build healthier lives for themselves and their children.

  Recruiting at 2 sites University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT05534568

• Impact of Menstrual Cycle Phase on Smoking Cessation

  This study tests if starting smoking cessation treatment during certain phases of the menstrual cycle helps women quit smoking more successfully.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05515354

• A program to help teens reduce cannabis and alcohol use

  This study is testing a new computer program to help teens aged 13-17 cut down on their use of cannabis and alcohol.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05486234

• Written Exposure Therapy for Veterans with Substance Use Disorders and PTSD

  This study is testing if written exposure therapy can help veterans with substance use disorders and PTSD feel better and improve their recovery compared to a standard treatment.

  Recruiting VA Office of Research and Development · West Haven, Connecticut · NCT05327504

• A tool to help women with substance use disorders make reproductive decisions after childbirth

  This study is testing a new tool called MyPath to help women with substance use disorders make better choices about birth control after having a baby.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT04939012

• Community-based program for youth with opioid use disorder

  This study is testing a community program that helps young people with opioid use disorder get better treatment and support to see if it keeps them engaged in recovery and reduces overdoses.

  Recruiting Phase 4 The University of Texas Health Science Center, Houston · Houston, Texas · NCT04811014

• Understanding Problematic Internet Use in Children and Adolescents

  This study looks at how kids and teens use the internet and whether their online habits, like gaming and social media use, are linked to mental health issues like ADHD and anxiety.

  Recruiting Psychiatric University Hospital, Zurich · Zurich, Canton of Zurich · NCT04723498

• Cognitive training for improving mental health in forensic patients

  This study is testing if a special brain training program can help improve thinking skills and mental health for people in a secure facility.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT04610697

• Using brain stimulation to improve thinking skills in people with mental health conditions

  This study is testing if a brain stimulation treatment can help improve thinking skills in people with mental health conditions like depression, bipolar disorder, and ADHD.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04296604

• Using focused ultrasound to treat opioid and substance use disorders

  This study is testing whether a new ultrasound treatment can help people with opioid and substance use disorders feel better and manage their conditions safely.

  Recruiting at 3 sites InSightec · Tampa, Florida and 3 other locations · NCT04197921

• Using brain stimulation to reduce cravings in methamphetamine users

  This study tests whether a type of brain stimulation can help reduce cravings for methamphetamine in adults who are trying to stay off the drug.

  Recruiting Oregon Health and Science University · Portland, Oregon · NCT03470480

• Implementing HIV testing in opioid treatment programs

  This study is testing if coaching programs can help people in opioid treatment programs get more HIV and Hepatitis C tests and connect to care.

  Recruiting Columbia University · New York, New York · NCT03135886

NIH-funded research (newest 40 of 110)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Improving contraception decisions for women with substance use disorders after childbirth

  A patient-centered decision tool called MyPath aims to help postpartum women with substance use disorders choose and keep effective contraception after giving birth.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11601588

• Transforming prison care for HIV, HIV risk, and substance use disorders

  A patient-friendly look at improving HIV care and prevention for people in state prisons, especially where substance use is common.

  NIH research University of Washington · Seattle, United States · NIH-11567794

• Genetic factors behind alcohol and opioid use disorders and depression in veterans

  A study using genetic data from veterans to understand how genes contribute to co-occurring alcohol use, prescription opioid use, and depression.

  NIH research Philadelphia VA Medical Center · Philadelphia, United States · NIH-11536898

• Written Exposure Therapy for Veterans with PTSD and Substance Use Disorder (brief trauma treatment)

  A brief trauma-focused therapy called Written Exposure Therapy is being studied to help veterans who have both PTSD and substance use disorders.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11533114

• Web-based training to treat PTSD and substance use together in Veterans

  A web-based training resource helps VA clinicians learn how to provide integrated treatment for Veterans with both PTSD and substance use disorders.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11458134

• Mobile health support to help Veterans with substance use disorders function better after treatment

  A smartphone app, based on Motivational Enhancement Therapy, is being developed to help Veterans stay on track and function better after leaving residential substance use treatment.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11458044

• AI-augmented care to guide hospital treatment for opioid and alcohol use disorders

  A hospital-based AI tool helps clinicians decide and guide treatment for patients with opioid or alcohol use disorders in ED and inpatient settings.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11455604

• Adaptive design optimization to build quick, reliable behavioral tests for substance use disorders

  A researcher team will test a smarter way to measure thinking, motivation, and emotions in people with substance use issues, using quick, precise tasks.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11455249

• Adaptive design-optimized behavioral tasks for substance use disorders

  A new project will use smart, data-driven methods to quickly and reliably measure brain- and behavior-related traits in people with substance use disorders.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11455248

• Helping families coping with overdose bereavement and substance use support

  A patient-friendly program tests a peer grief support approach to help people who lost loved ones to overdose and may also help reduce risky substance use.

  NIH research Stanford University · Stanford, United States · NIH-11454648

• Adaptive design optimization to create rapid, reliable behavioral tests for substance use disorders

  Aims to speed up and improve the reliability of behavioral tests used to understand and treat substance use disorders.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11399689

• Massively parallel test of brain gene switches in fentanyl-exposed mice

  Researchers will test how specific genetic switches in the brain respond after chronic fentanyl exposure, using a new high-throughput method in live mice.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11397239

• Faster, smarter behavioral tests for alcohol and drug problems

  This project will create shorter, computer-based tasks that quickly capture brain and behavior patterns linked to substance use problems for people with alcohol or other drug issues.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11386167

• Rapid, reliable tests for thinking, cravings, and mood in addiction

  This project uses smart, computer-driven testing to make shorter, more reliable tasks that measure thinking skills, reward responses, and negative emotions in people with substance use problems.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-11386166

• Reducing stigma and shame to improve HIV care for people with HIV and substance use

  A big study tests a supportive program designed to help people living with HIV and substance use disorders stay engaged in care and maintain viral suppression.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11384200

• Genetics of PTSD and Substance Use in Diverse Populations

  This grant investigates how genes influence PTSD and substance use disorders in diverse groups to improve prevention and treatment.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11381617

• High-throughput testing of gene variants linked to substance use disorders

  Scientists will rapidly test many genetic variants tied to substance use disorders to understand which ones affect biology in humans.

  NIH research Washington University · Saint Louis, United States · NIH-11367912

• Combined recovery program and home telehealth for Veterans leaving VA hospitals

  This project combines group recovery sessions with nurse-supported home telehealth to help Veterans with substance use disorders stay connected to care after leaving the VA hospital.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11363720

• Multimodal approach to craving and mood in substance use disorders

  Aims to build a real-world and lab-based picture of how cravings and moods relate to substance use by collecting brain, physiological, and behavioral data from people with SUD.

  NIH research Rice University · Houston, United States · NIH-11362304

• Integrated eHealth delivery of PrEP and MOUD for women in the criminal-justice system

  A patient-friendly study that tests remote, combined PrEP and addiction medicine support for women involved with the criminal justice system in CT and AL.

  NIH research Yale University · New Haven, United States · NIH-11358342

• Helping people leaving prison with substance use get connected to healthcare

  This project tries a nurse-led program that starts before release and continues after to help adults with substance use histories leaving prison connect to medical and addiction care.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11348910

• Closing gaps in substance use care for Indigenous Veterans

  Aims to understand and improve how the VA provides quality alcohol and other substance use treatment for Indigenous Veterans.

  NIH research Minneapolis VA Medical Center · Minneapolis, United States · NIH-11348477

• Matching Treatments to Cognitive Deficits in Offenders with Substance Use Disorders

  A clinical trial tests targeted cognitive skills training to help offenders with substance use disorders who have specific thinking and behavior problems.

  NIH research Lovelace Biomedical Research Institute · Albuquerque, United States · NIH-11336916

• Resource center supporting parents with substance use challenges

  A community-driven resource center will work with parents who use substances to create parenting-friendly supports and reduce barriers to treatment.

  NIH research University of Oregon · Eugene, United States · NIH-11322045

• Clinical decision support to spot relapse risk early in teens with substance use disorders

  A new tool called LEVL helps clinicians spot early signs that a teen recovering from substance use might relapse, so they can intervene sooner.

  NIH research Pillsmart INC. · Brooklyn, United States · NIH-11316815

• How Medicaid managed care changes affect people with substance use disorders

  This project looks at how Medicaid managed care plans entering or leaving a state influence access to medications and continuity of care for adults with substance use disorders.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11306033

• Identifying how drugs affect brain proteins in addiction

  This study is looking at how drug use, like cocaine, changes the proteins in the brain, and it's for people who want to understand addiction better and find new ways to help those dealing with substance use issues.

  NIH research Princeton University · Princeton, UNITED STATES · NIH-11302129

• Understanding genes linked to substance use disorders to help predict risk

  A study using genetic information to better understand why some people develop substance use problems and how these genes influence risk over time.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11296320

• Tools to speed discovery of new medicines for addiction and overdoses

  This project is making faster lab methods to find new drugs that could help people with addiction, reduce drug-seeking, or reverse overdoses.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11291799

• Mobile app plus peer support to help people with HIV and substance use stay healthy

  This project uses a mobile health app together with trained peer mentors to help people living with HIV who also struggle with substance use stay on treatment and keep their viral load low.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11285266

• How HIV and COVID medicines and substance use can harm the liver

  Researchers are looking at how common HIV and COVID-19 antiviral drugs, especially when combined with alcohol or other substance use, can damage the liver in people with these viral infections.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11258056

• CHARTER Plus: improving brain and mental health for people with HIV and substance use

  This project builds a long-term resource of brain tests, mental-health measures, and stored samples to help adults with and without HIV better understand and protect their brain health across life.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11251656

• Helping children of parents with substance use disorders improve early language skills

  This project looks at whether adding one-on-one parent coaching to group language programs helps infants and young children of parents with substance use disorders build stronger early language skills.

  NIH research University of Oregon · Eugene, United States · NIH-11238887

• How social connections affect mental health, substance use, and HIV care during COVID

  This project looks at how loneliness and social connections relate to mental health, substance use, and staying on HIV treatment for people living with HIV during the COVID era.

  NIH research Suny Downstate Medical Center · Brooklyn, United States · NIH-11230247

• Using Written Exposure Therapy to help Veterans with PTSD and Substance Use Disorders

  This study is looking at how helpful Written Exposure Therapy can be for Veterans dealing with both PTSD and substance use issues, especially for those in rural areas who might not have easy access to care, to see if it can make their treatment better and improve their quality of life.

  NIH research Salem VA Medical Center · Salem, United States · NIH-11229562

• Helping Veterans with Bipolar Disorder and Substance Use Issues After Hospitalization

  This study is all about helping Veterans who are dealing with both bipolar disorder and substance use issues after they leave the hospital, by creating supportive follow-up plans that make it easier for them to stick to their treatment and stay healthy.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11222679

• Online training for clinicians to deliver COPE, a combined PTSD and substance-use therapy

  This project offers web training to teach VA clinicians how to deliver COPE, a combined Prolonged Exposure therapy for Veterans with PTSD and substance use problems.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11222678

• Finding the right treatments for cognitive issues in offenders with substance use problems

  This study is looking at how to help people with substance use issues who also have trouble with thinking and attention by matching them with special training programs that fit their needs, so they can improve their skills and feel better.

  NIH research Lovelace Biomedical Research Institute · Albuquerque, United States · NIH-11193431

• Helping Veterans with Bipolar Disorder and Substance Use Issues After Hospitalization

  This study is all about helping Veterans who have bipolar disorder and struggle with substance use after they leave the hospital, by creating supportive follow-up plans that make it easier for them to stick to their treatment and stay healthy.

  NIH research Providence VA Medical Center · Providence, United States · NIH-11179435

• Understanding the genetics behind substance use disorders

  This study is looking at how our genes might influence substance use disorders, with the hope of finding new ways to help people struggling with addiction by using advanced genetic testing.

  NIH research Yale University · New Haven, United States · NIH-11168362

Related topics

Quick answers

How many Substance Use Disorders clinical trials are recruiting right now?

58, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (42 trials), Canada (5 trials), Germany (4 trials), Switzerland (2 trials), Turkey (Türkiye) (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →