Serratus block vs ESP block for pain after unilateral breast surgery
Official title: Comparison of Serratus Posterior Superior Intercostal Plane Block and Erector Spinae Plane Block for Postoperative Analgesia in Unilateral Breast Surgery: A Prospective, Randomized, Assessor-Blinded Trial
Run by Kocaeli City Hospital · NCT07541040 · Data updated 2026-11-12
This trial tests whether the serratus posterior superior intercostal plane block (SPSIPB) provides similar or better pain relief than the erector spinae plane block (ESPB) after unilateral breast surgery in adult women.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 65 Years |
| Sex | Women only |
| Enrollment | 54 (estimated) |
| Sponsor | Kocaeli City Hospital Government |
| Locations | 1 site (İzmit, Kocaeli) |
| Status | Recruiting |
| Started | May 1, 2026 |
| Main results expected | November 1, 2026 |
| Study ends | November 1, 2026 |
| Registry record updated | September 30, 2026 |
| Trial ID | NCT07541040 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adult women (18-65) with ASA I-III undergoing elective unilateral breast surgery, without contraindications to regional anesthesia or chronic opioid use.
✕Probably not a fit
Patients with infections at the block site, known local anesthetic allergy, coagulopathy, pregnancy, or those requiring additional intraoperative analgesia outside the protocol may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This is a prospective, randomized, assessor-blinded study at a single center that assigns 54 adult female patients to receive either SPSIPB or ESPB under ultrasound guidance before anesthesia for unilateral breast surgery. All participants follow standardized general anesthesia and multimodal postoperative analgesia. Pain is measured with the Numerical Rating Scale during the first 24 hours, at rest and with movement, to compare analgesic effectiveness and total opioid use between groups.
Why it matters
Potential benefit: If SPSIPB provides equal or better analgesia, patients may experience better early postoperative pain control and potentially reduced opioid needs.
How similar studies have gone: Prior research has explored regional blocks for breast surgery, with mixed results; this study tests SPSIPB against ESPB in a rigorous randomized design.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Female patients aged 18-65 years * ASA physical status I-III * Body mass index (BMI) between 18 and 35 kg/m² * Scheduled for elective unilateral breast surgery (mastectomy with or without sentinel lymph node biopsy) * Ability to understand and provide written informed consent Exclusion Criteria: * Infection at the site of block application * Known allergy to local anesthetics * Coagulopathy or anticoagulant therapy * Chronic opioid use * Pregnancy * Inability to communicate or cooperate * Refusal to participate * Failed block * Requirement of additional intraoperative analgesia outside the study protocol * Development of serious intraoperative complications
Where it's running
-
University of Health Sciences Kocaeli City Hospital
İzmit, Kocaeli, Turkey (Türkiye) Recruiting
Study contacts
- Principal investigator: Engin Çetin, M.D — Kocaeli City Hospital
- Study coordinator: Engin Çetin, M.D.
- Email: Doccetin52@gmail.com
- Phone: 5321206004
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.