Comparing brain activity in women with chronic pain and opioid use to healthy women

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to investigate the differences in brain activity between female adults suffering from chronic pain and/or using opioids and healthy female adults. It employs neuroimaging techniques such as MRI and fMRI, alongside behavioral tasks, sensory testing, blood draws, and questionnaires to gather comprehensive data. The goal is to identify neurophysiological and behavioral variations that could inform the development of targeted treatments for chronic pain and alternatives to opioid therapy. The data will be analyzed using specialized software for neuroimaging and standard statistical methods for other assessments.

Why it matters

Who can join: the full rules

Inclusion Criteria for Healthy Controls:

1. female and ages 18+
2. ability to read/understand English and give consent to participate
3. no current or history of chronic pain
4. not regularly taking any pain-relieving or mood-altering medications (per PI discretion)
5. absence of use of opioid medications

Inclusion Criteria for Individuals with Chronic Pain:

1. female and ages 18 +
2. ability to read/understand English and give consent to participate
3. self-reported or physician diagnosis of fibromyalgia and/or chronic pain
4. current use of opioid medication(s) for inclusion in the opioid patient group -OR- absence of use of opioid medications for inclusion in the non-opioid patient group

Exclusion Criteria (for both groups):

1. limited ability to participate fully in behavioral tasks, longitudinal follow-up
2. MRI contraindication
3. any factors that at the discretion of the investigators would adversely affect the participant or the integrity of the study
4. male

Where it's running

• Duke University Medical Center
  Durham, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Katherine T Martucci, PhD — Duke University
• Study coordinator: HAPN Lab Manager
• Email: chronicpainresearch@duke.edu
• Phone: 919-684-2758

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.