MGRNOX-guided general anesthesia to reduce opioid use during laparoscopic gallbladder surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Adults scheduled for elective laparoscopic cholecystectomy under general anesthesia are assigned to analgesia guided by the EEG-derived MGRNOX index or to standard clinical care. In the MGRNOX arm anesthesiologists titrate intraoperative opioid dosing based on the index, while the control arm uses routine signs such as heart rate and blood pressure. Primary outcome measures include intraoperative opioid consumption, with secondary outcomes covering postoperative pain, hemodynamic stability, opioid-related side effects, and recovery metrics. The trial is run at Peking University Shenzhen Hospital and excludes patients with chronic pain, recent opioid use, significant comorbidities, pregnancy, or extreme BMI or age.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years old and \< 65 years old；
* American Society of Anesthesiologists (ASA) class I-II；
* Scheduled to undergo elective laparoscopic cholecystectomy undergeneral anesthesia （without epidural anesthesia, local blocks, or infiltration）

Exclusion Criteria:

* Pregnancy or lactation period；
* BMI ≥35 kg/m² or \<18.5 kg/m²；
* Anticipated difficult airway；
* Previous diagnosis of hypertension；
* History of drug or alcohol abuse within the past 6 months；
* Preoperative acute or chronic pain history (routine preoperative use of opioid or non-opioid analgesics), peripheral or central nervous system-related disorders；
* Definitively diagnosed psychiatric disorders or other neuropsychiatric conditions severely affecting cognitive judgment, history of psychotropic medication use；
* Allergy or intolerance to anesthetic agents；
* Baseline mean arterial pressure (MAP) \<60 mmHg or \>120 mmHg; baseline heart rate (HR) \<45 bpm or \>90 bpm (Baseline values defined as first measurement taken in the ward after admission)；
* History of severe underlying diseases (untreated or ongoing peripheral/central cardiovascular diseases, severe hepatic disorders with elevated bilirubin/INR or hypoalbuminemia, severe renal diseases with elevated creatinine, severe pulmonary diseases potentially causing acute respiratory failure or persistent dyspnea)；
* Implanted pacemaker, chronic arrhythmia, preoperative use of prescribed anticholinergics, α2-adrenergic agonists, beta-1 adrenergic antagonists, or antiarrhythmic medications.

Where it's running

• Peking University Shenzhen Hospital
  Shenzhen, Guangdong, China Recruiting

Study contacts

• Principal investigator: Tao Luo, MD,PHD — Peking University Shenzhen Hospital
• Study coordinator: Tao Luo, MD,PHD
• Email: luotao_wh@yahoo.com
• Phone: 13510820779

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.