Examining the link between sex hormones, pain after surgery, and opioid use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to explore the relationships between sex hormone levels and postoperative pain as well as opioid use in pediatric female patients aged 11-16 undergoing orthopedic surgeries. Participants will complete various surveys regarding demographics, pain, and substance use, and provide blood samples for hormonal and immune analysis. Data on postoperative pain and opioid use will be collected during the hospital stay and through follow-up interviews at multiple intervals post-surgery. The study seeks to understand if testosterone affects pain and opioid use through immune factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Pediatric female patients between the ages 11-16 undergoing an orthopedic (trauma and non-trauma) surgical procedure involving a long bone or joint, or the spine, English speaking

Exclusion Criteria:

Pregnancy; Diagnosis of chronic pain, Psychiatric, developmental or neurological disorders, Disorders that are associated with pubertal maturation (e.g., precocious puberty).

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.