Using motivational interviewing and mindfulness to help reduce substance use

Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE) for Tobacco Dependence and Other Drug Use in Methadone Treatment

Phase 3 Interventional Rutgers, The State University of New Jersey · NCT06033599

This study is testing whether combining motivational interviewing and mindfulness techniques can help people who struggle with using multiple substances, like opioids and tobacco, to reduce their use.

Quick facts

PhasePhase 3
Study typeInterventional
Enrollment420 (estimated)
Ages18 Years and up
SexAll
SponsorRutgers, The State University of New Jersey Academic / other
Locations2 sites (New Brunswick, New Jersey and 1 other locations)
Trial IDNCT06033599 on ClinicalTrials.gov

What this trial studies

This study aims to explore the implementation of Motivational Interviewing (MI) and Mindfulness-Oriented Recovery Enhancement (MORE) for individuals struggling with polysubstance abuse, particularly focusing on opioid and tobacco use. It will assess barriers and facilitators to the adoption of these interventions in clinical settings while also evaluating their effectiveness in reducing substance use among participants. The study will involve various treatment groups, including those receiving MI and MORE, as well as support groups, to determine the best approach for patient outcomes.

Who should consider this trial

Good fit: Ideal candidates for this study are English-speaking adults aged 18 and older who are currently on methadone and smoke cigarettes.

Not a fit: Patients with severe cognitive impairment, psychosis, or those who are currently pregnant or breastfeeding may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could provide effective strategies for reducing substance use and improving recovery outcomes for individuals with polysubstance abuse issues.

How similar studies have performed: Other studies have shown promise in using motivational interviewing and mindfulness techniques for substance use treatment, indicating that this approach has potential for success.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* English-speaking
* Age ≥18
* Currently on methadone; and 4) currently smoke cigarettes.

Exclusion Criteria:

* Severe cognitive impairment (score \>23 on Mini Mental Status Exam) or psychosis (positive SCID Psychotic Screen)
* Suicidal risk (score ≥7 on Suicidal Behaviors Questionnaire)
* Inability to attend or fully participate in intervention sessions or assessments
* Previous formal mindfulness training (e.g., MBSR, MBRP) or MORE (from the R21 or R33
* Currently taking smoking cessation pharmacotherapy or participating in smoking cessation counseling
* Any contraindications for NRT
* Currently or soon planning to be pregnant or breastfeeding.

Where this trial is running

New Brunswick, New Jersey and 1 other locations

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Polysubstance AbuseOpioid UseTobacco Use
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.