Examining brain activity patterns related to opioid relapse during treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the functional connectivity patterns in the brain using fMRI to understand the risk of relapse to illicit opioids among individuals undergoing treatment for opioid use disorder. Participants will be those who have recently started treatment with methadone or buprenorphine at the APT Foundation. The study aims to identify brain activity that correlates with relapse risk during this critical period of treatment. By analyzing these patterns, researchers hope to gain insights that could inform future interventions and support strategies for individuals in recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* recent initiation of methadone or buprenorphine at a clinic, program, or doctor within the past year (i.e., period of time during which treatment drop-out and risk for relapse is highest);
* eligibility for MRI scanning;
* ability to commit to study visits.

Exclusion Criteria:

* current acute psychosis, mania, or suicidal ideation with intent, as assessed during screening with the SCID-5;
* current intoxication or acute withdrawal at time of study visit sufficient to prevent participation based on: behavioral observation, breathalyzer, and SOWS assessment;
* severe cognitive impairment as determined via trained clinical research staff through consent process and during consent quiz or as indicated by a PROMIS Cognitive Function tscore \<30 (i.e., severe impairment)
* past or present history of intellectual disability, developmental disorder, or neurological disease;
* head trauma with loss of consciousness \>30 min;
* organ dysfunction or any unstable or untreated medical conditions that may interfere with study participation.

Where it's running

• Hartford Healthcare
  Hartford, Connecticut, United States Recruiting
• The APT Foundation
  New Haven, Connecticut, United States Recruiting

Study contacts

• Principal investigator: Sarah Yip, PhD, MSc — Yale University
• Study coordinator: Monica Holler
• Email: monica.holler@yale.edu
• Phone: 203-278-1107

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.