Condition

Post Operative Pain clinical trials and research

• 67Clinical trials
• 4NIH research projects
• 18Countries

Newest Post Operative Pain clinical trials

All recruiting trials (67)

• Magnesium given during colorectal cancer surgery to see if it lowers inflammation afterward

  We’re testing whether giving magnesium sulfate during open colorectal cancer surgery can reduce postoperative inflammation in patients.

  Recruiting Ain Shams University · Cairo, Abbassia · NCT07803601

• Novel nanoparticle-enhanced disinfection for post-operative tooth pain

  A new nanoparticle-based disinfection method is being tested to see if it reduces pain after root canal treatment in adults with certain tooth infections.

  Recruiting Minia University · Minya · NCT07800403

• Oral tizanidine before surgery to calm pain after leg surgery

  This trial tests whether giving a preoperative dose of oral tizanidine helps reduce postoperative pain and improve sleep quality for adults undergoing lower limb orthopedic surgery.

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT07800364

• Influence of Irrigant Delivery Methods on Postoperative Pain after Root Canal Treatment in Oval Canals

  This trial tests whether different irrigant delivery and activation methods affect postoperative pain after primary root canal treatment in adults.

  Recruiting Minia University · Minya · NCT07788027

• Effect of NeoSEALER FLO and AH Plus Sealer on Pain and Healing after Root Canal Treatment

  This test compares NeoSEALER FLO and AH Plus sealer to see how they affect postoperative pain and healing of periapical lesions in mature permanent teeth.

  Recruiting Minia University · Minya · NCT07785973

• ANTALGEEK Thess Monitoring for outpatient postoperative pain and recovery

  This study tests whether using the ANTALGEEK Thess monitoring device at home, plus a fixed analgesia plan, helps manage acute postoperative pain in adults after outpatient surgery.

  Recruiting Centre Hospitalier Universitaire de Nīmes · Nîmes, Gard · NCT07680998

• Nano-sized intracanal medications to reduce periapical inflammation after root canal retreatment

  This trial tests whether nano-calcium hydroxide or nano-chitosan pastes can reduce periapical inflammation and post-operative pain in adults undergoing endodontic retreatment of single-rooted teeth.

  Recruiting Al-Azhar University · Cairo, Nasr City · NCT07571837

• Preemptive pain relief for jaw surgery

  This study tests whether giving pain medicine before surgery reduces early postoperative pain for adults having orthognathic (jaw) surgery.

  Recruiting Phase 4 University of Puerto Rico · San Juan · NCT07571252

• Comparing two ultrasound-guided nerve blocks for pain after open kidney removal

  We will test whether a serratus intercostal plane block or an erector spinae plane block provides better pain relief for adults having open nephrectomy.

  Recruiting Fayoum University Hospital · Al Fayyum · NCT07556536

• Suzetrigine to reduce pain after total knee replacement

  This trial tests whether giving Suzetrigine before surgery helps adults having total knee replacement use fewer opioids and have less postoperative pain.

  Recruiting Phase 3 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07548385

• Serratus block vs ESP block for pain after unilateral breast surgery

  This trial tests whether the serratus posterior superior intercostal plane block (SPSIPB) provides similar or better pain relief than the erector spinae plane block (ESPB) after unilateral breast surgery in adult women.

  Recruiting Kocaeli City Hospital · İzmit, Kocaeli · NCT07541040

• M-TAPA versus port-site local anesthetic for pain control after pediatric laparoscopic abdominal surgery

  This trial will test whether an ultrasound-guided M-TAPA nerve block reduces postoperative pain compared with standard port-site local anesthetic injections in children aged 1–7 having laparoscopic abdominal surgery.

  Recruiting Kasr El Aini Hospital · Cairo, Elmanial · NCT07540689

• Suzetrigine added to multimodal opioid-sparing pain care for heart and weight-loss surgery

  This trial will test whether adding suzetrigine to standard multimodal pain care lowers opioid use and pain after bariatric or open-heart (sternotomy) surgery in adults.

  Recruiting Phase 3 Icahn School of Medicine at Mount Sinai · New York, New York · NCT07539623

• Measuring tongue and throat forces during direct laryngoscopy

  We will test whether measuring and then showing surgeons real-time forces on the tongue and throat during laryngeal surgery helps reduce postoperative pain, numbness, and taste changes in adults having direct laryngoscopy.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07434583

• Intrathecal versus epidural morphine for pain after cesarean delivery

  This test will compare a single intrathecal morphine shot versus epidural morphine for controlling pain in women having elective cesarean delivery.

  Recruiting Phase 4 Hospital Central do Funchal · Funchal, Madeira · NCT07386353

• Pulpotomy versus root canal for painful lower premolars and molars

  This study will see if total pulpotomy, radicular pulpotomy, or root canal treatment best controls postoperative pain and leads to successful outcomes for people aged 15–45 with symptomatic irreversible pulpitis in mandibular premolars and molars.

  Recruiting Mustafa Kemal University · Hatay, Antakya · NCT07375576

• Two root canal techniques for postoperative pain and neuropeptide levels

  This trial will test whether a manual-less rotary approach to root canal treatment causes less postoperative pain and different levels of substance P and CGRP than the conventional rotary method in adults with symptomatic irreversible pulpitis of mandibular molars.

  Recruiting Alexandria University · Alexandria · NCT07357233

• Postoperative infusion pump versus nerve block for pain after knee or shoulder surgery

  This study will try a postoperative local anesthetic infusion pump versus a preoperative nerve block to see which reduces pain for adults having ACL, shoulder labrum/rotator cuff, or certain knee surgeries.

  Recruiting Phase 4 Rutgers, The State University of New Jersey · Somerset, New Jersey · NCT07349810

• Using a number-based pain score plus a simple activity score to guide rescue pain medicine after surgery

  This project will test whether using a combined numerical pain score and a simple Functional Activity Score to decide when to give rescue pain medicine helps adults recover after surgery.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo · NCT07310953

• Post‑operative pain after root canal using resin versus bioceramic sealers

  This study will test whether adults who receive a resin-based sealer or a bioceramic sealer during root canal treatment have different amounts of pain in the first 48 hours.

  Recruiting Prime Foundation · Peshawar, Khyber Pakhtoon Khawa(KPK)a · NCT07253025

• Intraoperative methadone for pain control after total hip replacement

  This trial tests whether a single intraoperative IV dose of methadone lowers immediate postoperative pain and reduces opioid use in adults having elective total hip replacement with spinal anesthesia.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT07227064

• Single-dose IV methadone during knee replacement to lower pain and opioid use

  This trial will test whether one intraoperative IV dose of methadone reduces pain and the need for opioid pain pills after elective total knee replacement in adults.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT07226076

• Prednisone after ureteroscopy with stent to reduce postoperative pain

  This study will try a short course of prednisone after ureteroscopy with a ureteral stent to reduce postoperative pain in adults with kidney or ureteral stones.

  Recruiting Phase 4 Mayo Clinic · Scottsdale, Arizona · NCT07223580

• Methadone to reduce long-term opioid use after major spine surgery

  This pilot trial will test whether a short course of postoperative oral methadone can help adults having multilevel lumbar or thoracic spine fusion use fewer opioids three months after surgery.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT07222072

• Prehabilitation within ERAS for gynecologic oncology surgery

  This trial tests whether a pre-surgery program of tailored exercise, immunonutrition (Ocoxin), breathing exercises and psychological support combined with ERAS helps people having gynecologic cancer surgery recover faster and with fewer complications.

  Recruiting Aristotle University Of Thessaloniki · Thessaloniki · NCT07210164

• Erector spinae plane block versus intrathecal morphine for recovery after cesarean

  This will test whether a postoperative erector spinae plane (ESP) block or intrathecal morphine helps women recover better after an elective cesarean delivery.

  Recruiting AUSL Romagna Rimini · Cesena, Forlì · NCT07202416

• Pre-surgery acetazolamide to reduce shoulder pain after laparoscopic hysterectomy

  This study will test whether a single preoperative dose of acetazolamide reduces shoulder and abdominal pain in women undergoing total laparoscopic hysterectomy.

  Recruiting Phase 4 Prisma Health-Upstate · Greenville, South Carolina · NCT07101250

• Combining ultrasonic cleaning and a 980 nm diode laser to reduce pain and bacteria after root canal treatment

  This trial will test whether adding ultrasonic activation plus a 980 nm diode laser during root canal treatment reduces post‑operative pain and bacterial load in adults aged 20–35 with single‑rooted necrotic teeth and small periapical lesions.

  Recruiting Al-Azhar University · Cairo · NCT07041736

• Lidocaine versus lidocaine plus dexmedetomidine for IV regional anesthesia in upper limb surgery

  This trial will test whether adding dexmedetomidine to lidocaine for intravenous regional anesthesia gives better pain relief and longer-lasting analgesia for adults having elective upper limb surgery under 45 minutes.

  Recruiting Phase 4 Fatima Memorial Hospital · Lahore, Punjab Province · NCT07034300

• Cryoablation to reduce pain after total knee replacement

  This trial tests whether adding cryoablation during total knee replacement helps people have less pain and need fewer opioid pain medicines.

  Recruiting NYU Langone Health · New York, New York · NCT06991231

• Comparing two types of nerve blocks for pain relief after breast surgery

  This study is testing which of two types of nerve blocks can better relieve pain for women after breast surgery.

  Recruiting Ain Shams University · Cairo , Abbassya · NCT06873893

• Ultrasound-guided auricularis magnus nerve block to reduce pain after middle ear surgery

  This study will test whether an ultrasound-guided auricularis magnus nerve block reduces postoperative pain and bleeding in adults having middle ear surgery.

  Recruiting Kocaeli University · Istanbul · NCT06869967

• Adding a serratus anterior plane block to a rhomboid intercostal block for pain control after VATS

  We will try adding a serratus anterior plane block to the usual rhomboid intercostal block for adults having VATS to see if it reduces postoperative pain and opioid use within 48 hours.

  Recruiting Al-Quds University · Hebron · NCT06838039

• Simethicone to reduce gas pain after foregut and bariatric surgery

  This trial will test whether simethicone (Gas-X) reduces gas pain and bloating in adults having foregut operations such as sleeve gastrectomy or gastric bypass.

  Recruiting Phase 4 Madigan Army Medical Center · Tacoma, Washington · NCT06812832

• Comparing dexmedetomidine and lignocaine for pain management in laparoscopic gallbladder surgery

  This study is testing whether dexmedetomidine or lignocaine works better for managing pain and recovery in patients having laparoscopic gallbladder surgery.

  Recruiting Phase 2/3 Sahiwal medical college sahiwal · Sahiwal, Punjab Province · NCT06740903

• Comparing two pain management techniques for children undergoing undescended testis surgery

  This study is testing which of two pain management techniques works better for young children having surgery for undescended testis to help them feel less pain after the operation.

  Recruiting at 2 sites Kanuni Sultan Suleyman Training and Research Hospital · Istanbul and 1 other locations · NCT06725862

• Comparing two pain relief methods after gallbladder surgery

  This study is testing two different ways to relieve pain after gallbladder surgery to see which one works better for adults.

  Recruiting Cumhuriyet University · Sivas · NCT06662617

• Comparing two pain relief techniques after thoracoscopic sympathectomy

  This study is testing which of two pain relief methods works better for adults recovering from surgery to treat sweating and other conditions.

  Recruiting Damanhour Teaching Hospital · Damanhūr, El-Beheira · NCT06653803

• Understanding pain in patients with opioid use disorder after spine surgery

  This study looks at how pain after spine surgery is different for people with opioid use disorder compared to those without, to help find better ways to manage their pain.

  Recruiting Boston Medical Center · Boston, Massachusetts · NCT06639438

• Using intravenous acetaminophen to prevent delirium after heart surgery

  This study is testing if giving acetaminophen through an IV can help prevent delirium in adults after heart surgery compared to taking it by mouth.

  Recruiting at 4 sites Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · Vancouver, British Columbia and 7 other locations · NCT06613178

• Comparing two types of nerve blocks for pain relief in femur fracture surgery

  This study is testing which of two types of nerve blocks can provide better pain relief for patients having surgery for femur fractures.

  Recruiting Phase 2/3 Sahiwal medical college sahiwal · Sahiwal, Punjab Province · NCT06568770

• Non-opioid pain management after breast surgery

  This study is testing whether non-opioid pain relief can help people recovering from breast surgery feel better and heal without using traditional opioid medications.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT06507345

• Lower versus standard abdominal gas pressure to reduce shoulder pain after gynecologic laparoscopy

  This trial will test whether using lower gas pressure (10 mm Hg) instead of standard pressure (15 mm Hg) during benign gynecologic laparoscopic surgery reduces shoulder-tip pain afterwards.

  Recruiting Mount Sinai Hospital, Canada · Toronto, Ontario · NCT06504277

• Liposomal bupivacaine versus standard bupivacaine with epinephrine for pain after adolescent spinal fusion

  This trial tests whether injecting liposomal bupivacaine instead of 0.25% bupivacaine with epinephrine during posterior spinal fusion reduces opioid use after surgery in adolescents aged 10 to 17 with idiopathic scoliosis.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06471348

• Using Vitamin B Complex for Pain Relief After Cesarean Section

  This study is testing if adding vitamin B complex to standard pain relief methods can help women recover better after a cesarean section while reducing the need for opioids.

  Recruiting Ain Shams University · Cairo, Egypt · NCT06446830

• Evaluating pain management after laparoscopic tubal sterilization

  This study is testing whether a combination of non-opioid pain medications can manage pain just as well as opioids after a laparoscopic tubal sterilization procedure.

  Recruiting Phase 4 Johns Hopkins University · Baltimore, Maryland · NCT06434233

• Using light therapy to help recovery after knee surgery

  This study tests if using near-infrared light therapy can help people over 20 recover better from knee surgery by reducing pain, swelling, and inflammation.

  Recruiting National Taiwan University Hospital Hsin-Chu Branch · Hsinchu · NCT06426251

• Comparing robotic and laparoscopic sleeve gastrectomy for obesity treatment

  This study is testing whether robotic sleeve gastrectomy works better than laparoscopic sleeve gastrectomy for people with obesity in terms of pain, recovery, and quality of life after surgery.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06425016

• Comparing two pain management techniques for children undergoing palate surgery

  This study is testing two different pain management techniques for kids aged 6-18 who are having palate surgery to see which one helps them feel less pain after the operation.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06420336

• Measuring heat from blue versus red dental curing lights during restorations

  This trial will see if red dental curing light causes less heat and less post-operative sensitivity than the standard blue light for people receiving restorative dental procedures.

  Recruiting University of Florida · Gainesville, Florida · NCT06418958

• Comparing two pain control methods after robotic sleeve gastrectomy

  This study is testing whether a new pain control method called Zynrelef works better than Exparel for managing pain after robotic sleeve gastrectomy surgery.

  Recruiting Early Phase 1 Texas Tech University Health Sciences Center · Lubbock, Texas · NCT06349772

• Comparing nerve block and morphine for pain relief after hip surgery

  This study tests whether a nerve block can provide the same pain relief as morphine for people recovering from hip surgery.

  Recruiting Centre Hospitalier Universitaire Vaudois · Lausanne, Canton of Vaud · NCT06317870

• Comparing high and low dose pain relief methods after heart valve surgery

  This study is testing whether a high or low dose of a new pain relief method can help patients after heart valve surgery feel less pain and use fewer opioids.

  Recruiting Jessa Hospital · Hasselt, Limburg · NCT06205875

• Comparing scar outcomes from different incision techniques in mastectomy

  This study is testing which type of incision technique during mastectomy leads to the best-looking scars for patients who aren't having immediate breast reconstruction.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06191159

• Using intra-nasal ketorolac to relieve pain from ureteral stents after ureteroscopy

  This study is testing whether a nasal spray of ketorolac can help relieve pain better than oral diclofenac for patients with ureteral stents after surgery.

  Recruiting Phase 1/2 University of Texas Southwestern Medical Center · Dallas, Texas · NCT06158620

• Using vitamin C to reduce pain after knee surgery

  This study is testing if giving vitamin C to people before and after knee surgery can help reduce their pain and improve their quality of life.

  Recruiting at 3 sites Phase 2 University Health Network, Toronto · Toronto, Ontario and 2 other locations · NCT06123715

• Comparing pain relief methods after cesarean sections

  This study is testing which pain relief method works best after cesarean sections, comparing different nerve blocks and morphine to help new moms feel better.

  Recruiting Assiut University · Asyut, Manfalout · NCT06088420

• Effect of Fluid Temperature on Hysteroscopy Outcomes

  This study tests whether using warmer or cooler fluid during hysteroscopy can improve image quality and reduce pain and risks for patients.

  Recruiting Ege University · Izmir · NCT05973045

• Presacral nerve block to reduce pain after total laparoscopic hysterectomy.

  This trial tries a presacral nerve block with ropivacaine versus a saline sham to see if it reduces pain after total laparoscopic hysterectomy in adults.

  Recruiting Phase 2 Mount Sinai Hospital, Canada · Toronto, Ontario · NCT05953766

• Comparing two methods for pain control after shoulder surgery

  This study is testing whether a new way of delivering pain relief after shoulder surgery works better than the standard method to help patients feel less pain and recover more comfortably.

  Recruiting Phase 4 University of Iowa · Iowa City, Iowa · NCT05868330

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Using dextromethorphan to manage pain after knee surgery

  This study is testing if dextromethorphan can help reduce pain after knee surgery for people getting a total knee replacement.

  Recruiting University of Southern California · Los Angeles, California · NCT05278494

• Comparing two types of nerve blocks for pain relief after abdominal surgery

  This study is testing which type of nerve block, the erector spinae plane block or the rectus sheath block, works better for pain relief after abdominal surgery to help adults recover with less need for opioids.

  Recruiting Damanhour Teaching Hospital · Damanhūr, El-Beheira · NCT05179928

• Managing pain after cesarean deliveries

  This study is testing if a special pain relief device can help women feel less pain and use fewer opioids after having a cesarean delivery.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT05131178

• Registry tracking outcomes of cryoanalgesia for post-operative pain management

  This study is tracking how well a new pain management technique using cryoablation of nerve blocks works for patients after surgery.

  Recruiting at 10 sites AtriCure, Inc. · Jacksonville, Florida and 10 other locations · NCT05110989

• Using a dexamethasone insert to manage pain and inflammation after vitreoretinal surgery

  This study tests if a new dexamethasone insert can better manage pain and inflammation after eye surgery compared to regular steroid eye drops for adults.

  Recruiting Phase 4 The Cleveland Clinic · Cleveland, Ohio · NCT04371445

• Improving outcomes for patients with postoperative pain

  This study is trying to find better ways to manage pain after surgery by collecting information from hospitals to see what works best for patients.

  Recruiting University of Jena · Jena · NCT02083835

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• An electrical device to relieve pain after surgery without drugs

  A new non-drug, non-invasive neuromodulation device called NOVABLOC aims to reduce post-operative pain and support rehab by blocking pain signals without affecting movement.

  NIH research Synaptrix INC · Alpharetta, United States · NIH-11408281

• Sex hormone changes and post-surgery pain in people

  This project looks at how changes in sex hormone levels might influence the development of chronic pain after surgery, using animal models informed by human biology.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11396518

• How changes in sex hormones affect long-term pain after surgery

  This project looks at whether shifts in sex hormones help explain who gets lasting pain after surgery and how pain treatments work for them.

  NIH research Texas Tech University Health Scis Center · Lubbock, United States · NIH-11176100

• How changes in sex hormones affect pain after surgery

  This study is looking at how changes in sex hormones might affect the way people feel pain after surgery, especially for those who have different hormone levels, to help improve pain management for everyone.

  NIH research Texas Tech University Health Scis Center · Lubbock, United States · NIH-10914920

Related topics

Quick answers

How many Post Operative Pain clinical trials are recruiting right now?

67, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 18 countries. The most sites are in United States (25 trials), Egypt (15 trials), Canada (6 trials), Turkey (Türkiye) (6 trials), Pakistan (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 12, Phase 3: 4, Phase 2: 2, Phase 2/3: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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