Opioid-free anesthesia for abdominal aortic aneurysm repair
Effect of a Perioperative Opioid Free Anesthesia-Analgesia (OFA-A) Strategy on Surgical Stress Response in Elective Open Abdominal Aortic Aneurysm Repair: A Prospective Randomized Study
This study is testing a new way to manage pain during and after surgery for abdominal aortic aneurysm repair without using opioids, to see if it helps patients recover better.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 40 (estimated) |
| Ages | 40 Years to 85 Years |
| Sex | All |
| Sponsor | University of Crete Academic / other |
| Locations | 1 site (Heraklion, Crete) |
| Trial ID | NCT04894864 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of an opioid-free anesthesia-analgesia strategy on surgical stress and postoperative outcomes in patients undergoing elective open abdominal aortic aneurysm repair. The study compares traditional opioid-based anesthesia with a multimodal approach that utilizes various anesthetic and analgesic agents to minimize opioid use. By focusing on reducing the inflammatory response associated with surgical trauma, the trial aims to improve patient recovery and reduce complications. The research is conducted at the University of Crete, involving patients aged 40 to 85 who meet specific eligibility criteria.
Who should consider this trial
Good fit: Ideal candidates for this study are patients aged 40 to 85 who are scheduled for elective open abdominal aortic aneurysm repair.
Not a fit: Patients who are immunocompromised, have active infections, or suffer from chronic inflammatory conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved postoperative recovery and reduced complications for patients undergoing high-risk abdominal surgeries.
How similar studies have performed: Other studies have shown promising results with opioid-free anesthesia approaches, indicating potential for success in this novel application.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patient Consent 2. Age between 40 and 85 years old 3. Patients undergoing Elective Open Abdominal Aortic Infrarenal Aneurysm Repair Exclusion Criteria: 1. Immunocompromised patients 2. Patients with active infection 3. Reoperation on the aorta 4. Inflammatory bowel Disease 5. Malignancy 6. Chronic Inflammatory conditions (e.g. Rheymatoid arthritis, Psoriatic arthritis) 7. Chronic corticosteroid or immunosuppressive drug use 8. Intraoperative transfusion with \>2 units of packed Red Blood Cells
Where this trial is running
Heraklion, Crete
- University of Crete — Heraklion, Crete, Greece (Recruiting)
Study contacts
- Study coordinator: George Papastratigakis, MD
- Email: papastratigakisg@gmail.com
- Phone: 00306979056672
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.