Blocking nerves during gallbladder surgery to reduce pain and nausea
Official title: Intraoperative Autonomic Blockade to Prevent Early Postoperative Pain After Laparoscopic Cholecystectomy: A Double-Blind, Randomized Controlled Trial
Run by Universidad Simón Bolívar · NCT06753500 · Data updated 2026-11-12
This study is testing if using a combination of a long-lasting pain medicine and a steroid during gallbladder surgery can help reduce pain and nausea for patients after the operation.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | Universidad Simón Bolívar Academic / other |
| Locations | 2 sites (Barranquilla, Atlantivo and 1 other locations) |
| Status | Recruiting |
| Started | January 15, 2025 |
| Main results expected | November 1, 2025 |
| Study ends | November 4, 2025 |
| Registry record updated | January 28, 2025 |
| Trial ID | NCT06753500 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include individuals scheduled for elective or emergency laparoscopic cholecystectomy due to cholelithiasis, with or without cholecystitis.
✕Probably not a fit
Patients with associated biliary pathologies or those requiring additional surgical procedures may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study investigates the use of a combination of Bupivacaine, a long-acting local anesthetic, and Dexamethasone, a corticosteroid, to infiltrate specific areas during laparoscopic cholecystectomy. The goal is to block the hepatic branches of the celiac plexus, which may improve visceral pain control and reduce the need for analgesics post-surgery. By enhancing pain management, the study aims to lower readmission rates and facilitate quicker recovery for patients. This approach has not been previously tested in the context of laparoscopic cholecystectomy.
Why it matters
Potential benefit: If successful, this technique could significantly improve postoperative pain management and recovery for patients undergoing gallbladder surgery.
How similar studies have gone: While this specific approach has not been tested, similar techniques in pain management have shown promise in other surgical contexts.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective or emergency laparoscopic cholecystectomy for cholelithiasis with or without cholecystitis. Exclusion Criteria: * Associated biliary pathologies (e.g., biliary pancreatitis, cholangitis). * Additional procedures, such as formal bile duct exploration. Conversion to an open approach * Anesthesia or Surgical complications that require intensive care unit * Allergies to local anesthetics
Where it's running
-
Clinica Portoazul
Barranquilla, Atlantivo, Colombia Recruiting -
clinica Iberoamerica
Barranquilla, Atlántico, Colombia Recruiting
Study contacts
- Study coordinator: Jorge Daes, MD
- Email: jorgedaez@gmail.com
- Phone: +573106363636
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.