Home-based prehabilitation program for liver transplant patients
Preoperative PREhabilitation in Patients Planned for LIVER Transplantation (PRELIVERT)
This study tests a home-based program that helps liver transplant patients get stronger and healthier before surgery to see if it improves their recovery and reduces complications.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Erasmus Medical Center Academic / other |
| Locations | 1 site (Rotterdam) |
| Trial ID | NCT06808945 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the feasibility and effectiveness of a multimodal home-based prehabilitation program for patients awaiting liver transplantation. The program lasts eight weeks and includes physical exercise, nutritional support, smoking cessation, and psychological counseling. The primary goal is to assess how well patients can engage with this program, while secondary objectives focus on improvements in surgical outcomes such as reduced complications and faster recovery. The study will be conducted at the Erasmus Medical Center in Rotterdam, Netherlands.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are anticipated to be waitlisted for liver transplantation and can participate in physical exercise.
Not a fit: Patients with recent major cardiovascular events, severe liver complications, or those who are hospitalized at the start of the study may not benefit from this program.
Why it matters
Potential benefit: If successful, this program could enhance the health and recovery outcomes for patients undergoing liver transplantation.
How similar studies have performed: While few studies have focused specifically on liver transplant patients, prehabilitation has shown success in improving outcomes in various surgical populations.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years, * Anticipated waitlisting for LT, * Speaks the Dutch language, * Understands the purpose of the study and has given written informed consent. Exclusion Criteria: * Experienced a major adverse cardiovascular event in the past six months, * Experienced a cerebrovascular incident in the past six months, * Medical history of an uncontrolled heart rhythm disorder, * Hepatic encephalopathy grade 3 or 4, * Acute liver failure, * Acute-on-chronic liver failure, * Hospitalization at start of the study. * Non-treated esophageal varices (i.e., no previous variceal eradication endoscopy or adequately dosed NSBB)
Where this trial is running
Rotterdam
- Erasmus Medical Center — Rotterdam, Netherlands (Recruiting)
Study contacts
- Study coordinator: Lysanne P.M. Beuk
- Email: l.p.m.beuk@erasmusmc.nl
- Phone: +31615822753
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.