Using MR-proADM to predict complications after kidney and liver transplants
Official title: MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation
Run by University of Rome Tor Vergata · NCT06130046 · Data updated 2026-11-12
This study is testing if measuring a specific protein can help doctors predict complications like delayed graft function and acute rejection in people who have received kidney or liver transplants.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 300 (estimated) |
| Sponsor | University of Rome Tor Vergata Academic / other |
| Locations | 1 site (Rome) |
| Status | Recruiting |
| Started | December 1, 2022 |
| Main results expected | May 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | August 1, 2025 |
| Trial ID | NCT06130046 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are individuals who are kidney or liver transplant recipients at the University of Rome Tor Vergata.
✕Probably not a fit
Patients who have undergone re-transplantation, dual kidney transplantation, combined organ transplants, or have autoimmune diseases as an indication for transplant may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to evaluate the sensitivity and specificity of MR-proADM levels as an early, non-invasive biomarker for diagnosing delayed graft function (DGF) and acute rejection (AR) in kidney and liver transplant recipients. By measuring MR-proADM levels pre-operatively and post-operatively, the study will develop a predictive model using machine learning to identify patients at risk for these complications. The goal is to improve early diagnosis and management of post-transplant complications, ultimately enhancing patient outcomes.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection and management of complications in transplant patients, potentially reducing morbidity and mortality.
How similar studies have gone: While MR-proADM has shown promise as a prognostic marker in other contexts, this specific application in kidney and liver transplantation is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Kidney transplant recipient at our Institution * Liver transplant recipient at our Institution Exclusion Criteria: * Re-transplantation * Dual kidney transplantation * Combined transplant (kidney-liver, kidney-pancreas) * Autoimmune disease as indication to transplant
Where it's running
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University of Rome Tor Vergata
Rome, Italy Recruiting
Study contacts
- Principal investigator: Roberta Angelico, PhD FEBS — University of Rome Tor Vergata
- Study coordinator: Roberta Angelico, PhD FEBS
- Email: roberta.angelico@med.uniroma2.it
- Phone: 0620908294
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.