Clinical trial Recruiting at 1 site Observational Ages 18 to 70

Using MR-proADM to predict complications after kidney and liver transplants

Official title: MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation

Run by University of Rome Tor Vergata · NCT06130046 · Data updated 2026-11-12

This study is testing if measuring a specific protein can help doctors predict complications like delayed graft function and acute rejection in people who have received kidney or liver transplants.

Quick facts

Study typeObservational
Ages18 Years to 70 Years
SexAll
Enrollment300 (estimated)
SponsorUniversity of Rome Tor Vergata
Academic / other
Locations1 site (Rome)
StatusRecruiting
StartedDecember 1, 2022
Main results expectedMay 1, 2026
Study endsDecember 1, 2026
Registry record updatedAugust 1, 2025
Trial IDNCT06130046 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals who are kidney or liver transplant recipients at the University of Rome Tor Vergata.

Probably not a fit

Patients who have undergone re-transplantation, dual kidney transplantation, combined organ transplants, or have autoimmune diseases as an indication for transplant may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the sensitivity and specificity of MR-proADM levels as an early, non-invasive biomarker for diagnosing delayed graft function (DGF) and acute rejection (AR) in kidney and liver transplant recipients. By measuring MR-proADM levels pre-operatively and post-operatively, the study will develop a predictive model using machine learning to identify patients at risk for these complications. The goal is to improve early diagnosis and management of post-transplant complications, ultimately enhancing patient outcomes.

Why it matters

Potential benefit: If successful, this study could lead to earlier detection and management of complications in transplant patients, potentially reducing morbidity and mortality.

How similar studies have gone: While MR-proADM has shown promise as a prognostic marker in other contexts, this specific application in kidney and liver transplantation is novel and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Kidney transplant recipient at our Institution
* Liver transplant recipient at our Institution

Exclusion Criteria:

* Re-transplantation
* Dual kidney transplantation
* Combined transplant (kidney-liver, kidney-pancreas)
* Autoimmune disease as indication to transplant

Where it's running

  • University of Rome Tor Vergata
    Rome, Italy
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.