Preoperative Carbohydrate Loading Before Liver Transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this randomized, controlled trial, adults undergoing elective liver transplantation are assigned to receive a 400 mL carbohydrate drink (Nutricia preOp) up to two hours before anesthesia or a placebo. The primary question is whether preoperative carbohydrate loading improves postoperative recovery and shortens ICU stay and time to oral intake and GI function. Participants are followed for 30 days after surgery with routine labs and imaging to assess outcomes. Randomization is 1:1 with a pre-specified 434-patient sample size; blinding is maintained for participants and study staff. No biological samples are collected for this trial.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age ≥ 18 years
* elective liver transplantation at the Department of General, Transplant, and Liver Surgery, Medical University of Warsaw
* grafts from brain-dead donors
* MELD score \<35

Exclusion Criteria:

* acute liver failure
* insulin-dependent diabetes mellitus
* gastroparesis
* mechanical bowel obstruction
* liver retransplantation within less than 6 months of the primary transplant

Where it's running

• Department of General, Transplant, and Liver Surgery, Medical University of Warsaw
  Warsaw, Poland Recruiting

Study contacts

• Principal investigator: Maciej Krasnodębski, MD, PhD — Department of General, Transplant, and Liver Surgery, Medical University of Warsaw
• Study coordinator: Maciej Krasnodębski, MD, PhD
• Email: maciej.krasnodebski@wum.edu.pl
• Phone: +48225992459

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.