Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
Official title: Innate-Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
Funded at University of California Los Angeles · NIH-11594128 · Data updated 2026-11-12
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | August 1, 2017 |
| Project end | July 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $390,000 |
| NIH project number | 5P01AI120944-10 |
| Project ID | NIH-11594128 on NIH RePORTER |
Who could benefit from this research
✓Could help
People undergoing liver transplantation at participating centers who consent to blood sampling and immune analyses.
✕Less likely to help
Patients who do not undergo post-transplant sampling or who do not experience relevant immune signals may not benefit directly.
What this research studies
If approved, this research looks at human liver transplant samples to identify immune signals that shape inflammation and tolerance after surgery. It will examine cell-free DNA, mitochondrial DNA, neutrophil traps, and other markers in blood before and after transplant to see how they influence macrophage behavior and T cell responses. The goal is to uncover targets that could be blocked or encouraged to protect the new liver and reduce rejection. The work combines human data with insights from prior animal studies to connect immune signals to clinical outcomes.
Why it matters
Potential benefit: If successful, findings could lead to therapies that reduce liver transplant rejection and improve graft survival.
How similar studies have gone: Previous mouse studies suggest innate and adaptive immune interactions influence transplant outcomes, but human translational data are needed.
Where this research is happening
-
University of California Los Angeles
Los Angeles, United States Active
Researchers
- Principal investigator: Reed, Elaine F — University of California Los Angeles
- Study coordinator: Reed, Elaine F
Related research
Other NIH-funded projects on the same topics.
-
Biomarker-guided reduction of immunosuppression after liver transplant
A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.
-
Understanding how liver disease progresses in people waiting for a liver transplant
A study will build a knowledge base that maps how liver disease worsens over time in patients on the transplant waitlist to improve care and planning.
-
Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
-
Pre-Transplant Immune Health Marker Panel to Predict Liver Transplant Outcomes
A patient-facing biomarker test used before liver transplant to help doctors estimate the risk of early death after the transplant.
-
Thinking skills and self-care after a liver transplant
This project follows people who received liver transplants to learn how changes in thinking and memory affect managing medicines, clinic visits, and overall health.
-
Integrated care to improve outcomes after early liver transplant for alcohol-associated liver disease
A multi-center study will pair liver transplant care with behavioral and biopsychosocial support to help people with alcohol-related liver disease who are considered for early transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.