Using miRNA profiles to improve immunosuppression management in liver transplant patients
miRNA profiling for monitoring and adjustment of immunosuppression in liver transplant recipients
This study is looking at how certain tiny molecules in your blood can help doctors better manage the medications you take after a liver transplant, making sure your body doesn’t reject the new organ while reducing side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10841109 on NIH RePORTER |
What this research studies
This research investigates how specific miRNA profiles can be used to monitor and adjust immunosuppressive therapy in liver transplant recipients. By analyzing serum samples from patients, the study aims to identify biomarkers that indicate immune activation and potential rejection of the transplanted organ. This personalized approach seeks to minimize the side effects associated with standard immunosuppressive protocols while maintaining effective organ function. The goal is to enhance patient outcomes by tailoring treatment based on individual immune responses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a liver transplant and are currently undergoing immunosuppressive therapy.
Not a fit: Patients who have not undergone liver transplantation or those who are not on immunosuppressive therapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective management of immunosuppression in liver transplant patients, reducing the risk of rejection and drug-related side effects.
How similar studies have performed: Previous studies have shown promise in using biomarker profiling for personalized medicine in transplant settings, indicating that this approach may be effective.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Shaked, Abraham Na — University of Pennsylvania
- Study coordinator: Shaked, Abraham Na
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.