Using miRNA profiles to improve immunosuppression management in liver transplant patients
Official title: miRNA profiling for monitoring and adjustment of immunosuppression in liver transplant recipients
Funded at University of Pennsylvania · NIH-10841109 · Data updated 2026-11-12
This study is looking at how certain tiny molecules in your blood can help doctors better manage the medications you take after a liver transplant, making sure your body doesn’t reject the new organ while reducing side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 9, 2024 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $264,596 |
| NIH project number | 1R34AI174991-01A1 |
| Project ID | NIH-10841109 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have received a liver transplant and are currently undergoing immunosuppressive therapy.
✕Less likely to help
Patients who have not undergone liver transplantation or those who are not on immunosuppressive therapy may not benefit from this research.
What this research studies
This research investigates how specific miRNA profiles can be used to monitor and adjust immunosuppressive therapy in liver transplant recipients. By analyzing serum samples from patients, the study aims to identify biomarkers that indicate immune activation and potential rejection of the transplanted organ. This personalized approach seeks to minimize the side effects associated with standard immunosuppressive protocols while maintaining effective organ function. The goal is to enhance patient outcomes by tailoring treatment based on individual immune responses.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective management of immunosuppression in liver transplant patients, reducing the risk of rejection and drug-related side effects.
How similar studies have gone: Previous studies have shown promise in using biomarker profiling for personalized medicine in transplant settings, indicating that this approach may be effective.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Shaked, Abraham Na — University of Pennsylvania
- Study coordinator: Shaked, Abraham Na
Related research
Other NIH-funded projects on the same topics.
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Biomarker-guided reduction of immunosuppression after liver transplant
A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.
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Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
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Using blood biomarkers to guide immunosuppression after liver transplant
This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.
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Using blood biomarkers to improve liver transplant immunosuppression
This study is looking at how certain blood tests can help doctors create personalized treatment plans for people who have received a liver transplant, making it easier to prevent rejection and protect kidney health.
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Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
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Understanding how liver disease progresses in people waiting for a liver transplant
A study will build a knowledge base that maps how liver disease worsens over time in patients on the transplant waitlist to improve care and planning.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.