Long-term health of children born to mothers who had a solid organ transplant
Official title: Long-term Follow-up of the Offspring Born to Mothers With a Solid Organ Transplant
Run by University Medical Center Groningen · NCT07291258 · Data updated 2026-11-12
This project will look for long-term heart, kidney, and immune system problems in people aged 16 and older who were born to mothers who had a kidney, liver, pancreas, heart, or lung transplant.
Quick facts
| Study type | Observational |
|---|---|
| Sex | All |
| Enrollment | 200 (estimated) |
| Sponsor | University Medical Center Groningen Academic / other |
| Locations | 1 site (Groningen, Provincie Groningen) |
| Status | Recruiting |
| Started | October 15, 2025 |
| Main results expected | December 2027 |
| Study ends | June 2028 |
| Registry record updated | December 18, 2025 |
| Trial ID | NCT07291258 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people aged 16 or older who were born after their mother had a kidney, liver, pancreas (including islet), heart, or lung transplant and who can give informed consent and speak Dutch or English.
✕Probably not a fit
Children under 16, offspring whose mother received a transplant after the pregnancy, people who cannot consent, or non–Dutch/English speakers are not eligible and would not benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Researchers at University Medical Center Groningen will enroll offspring aged 16 years and older who were born after a mother's solid organ transplant and collect medical history, questionnaires, physical exams, blood tests, blood pressure measurements, and kidney and cardiovascular assessments. The cross-sectional cohort is designed to identify cardiovascular, renal, and immunological outcomes that may appear only later in life, such as hypertension, reduced kidney function, or altered immune markers possibly related to prenatal exposure to immunosuppressive drugs. Findings will be compared with expected norms and existing literature to detect signals of late-onset health effects related to maternal transplantation and pregnancy complications. Participation requires ability to consent and communication in Dutch or English and takes place at UMCG.
Why it matters
Potential benefit: If successful, the results could clarify long-term health risks for these offspring and help doctors recommend targeted monitoring and care.
How similar studies have gone: Small studies in younger children have generally been reassuring, but very few studies have followed offspring into late adolescence or adulthood, making this a relatively novel long-term follow-up.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Mother with a KTx, LiTx, PTx (including pancreas islet transplantation), HTx or LuTx before pregnancy (including mothers with multiple transplantation types) * Age ≥16 years for offspring born to mother with a KTx or LiTx Exclusion Criteria: * No informed consent * Non Dutch or English speaking
Where it's running
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University Medical Center Groningen
Groningen, Provincie Groningen, Netherlands Recruiting
Study contacts
- Principal investigator: Margriet F.C. de Jong, MD, PhD, MBA — University Medical Center Groningen
- Study coordinator: Margriet F.C. de Jong, MD, PhD, MBA
- Email: m.f.c.de.jong@umcg.nl
- Phone: +31655256391
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.