Comparing two surgical techniques for bile duct connection in liver transplantation
Official title: A Prospective Randomized Study to Evaluate the Effect of the Type of Conduit-duct Anastomosis Using the Single/continuous Suture Technique on the Postoperative Course in Patients Undergoing Liver Transplantation from a Deceased Donor.
Run by Medical University of Warsaw · NCT06533592 · Data updated 2026-11-12
This study is testing two different surgical methods for connecting bile ducts during liver transplants to see which one leads to fewer complications and better recovery for patients.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 284 (estimated) |
| Sponsor | Medical University of Warsaw Academic / other |
| Locations | 1 site (Warsaw, Masovian Voivodeship) |
| Status | Recruiting |
| Started | September 28, 2024 |
| Main results expected | November 1, 2026 |
| Study ends | September 1, 2028 |
| Registry record updated | October 24, 2024 |
| Trial ID | NCT06533592 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over 18 years old who are undergoing elective liver transplantation from deceased donors.
✕Probably not a fit
Patients who are under 18, pregnant, or undergoing living donor liver transplantation will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial aims to evaluate the effectiveness of two surgical techniques for duct-to-duct anastomosis during liver transplantation: the continuous suture method and the interrupted suture method. A total of 284 patients undergoing elective liver transplantation from deceased donors will be randomized into two groups to assess the risk of bile leakages and other postoperative complications within a 90-day follow-up period. Additionally, long-term biliary complications will be monitored over a two-year observation period. The study focuses on improving postoperative outcomes and quality of life for liver transplant recipients.
Why it matters
Potential benefit: If successful, this study could lead to reduced rates of bile leaks and other complications following liver transplantation, improving patient recovery and quality of life.
How similar studies have gone: While there have been studies on surgical techniques in liver transplantation, this specific comparison of continuous versus interrupted suture methods is novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * age over 18 * elective liver transplantation * informed consent to participate in the study * recipient bile duct diameter over 3mm * donor bile duct diameter over 3mm Exclusion Criteria: * age below 18 * pregnancy * living donor liver transplantation * split-liver or reduced-size liver transplantation * liver transplantation other than from brain death donor * liver transplantation with hepaticojejunostomy * patients undergoing re-transplantation * multi-organ transplantation * recipient bile duct diameter below 3mm * donor bile duct diameter below 3mm
Where it's running
-
Department of General, Transplantation and Liver Surgery UCC MUW
Warsaw, Masovian Voivodeship, Poland Recruiting
Study contacts
- Study coordinator: Krzysztof Dudek, MD, PhD
- Email: krzysztof.dudek@wum.edu.pl
- Phone: +48 225992542
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.