Managing fluid strategies to reduce blood loss during liver transplantation
Effects of Different Fluid Management Strategies on Blood Loss, Inflammatory Response, and Major Organ Sequelae in Liver Transplantation
This study tests whether using different fluid management strategies during liver transplantation can help reduce blood loss and improve outcomes for patients.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 60 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06215404 on ClinicalTrials.gov |
What this trial studies
This study investigates the effects of different fluid management strategies on blood loss during liver transplantation. It employs a randomized group model to compare restrictive and liberal infusion approaches, utilizing the PiCCO monitor to assess cardiac output and stroke volume variation. The goal is to determine how these strategies impact bleeding volume and potential complications in major organs during the surgery.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 to 75 with end-stage liver disease who are expected to receive a liver transplant.
Not a fit: Patients with arrhythmias may not benefit from this study due to exclusion criteria.
Why it matters
Potential benefit: If successful, this study could lead to improved outcomes and reduced complications for patients undergoing liver transplantation.
How similar studies have performed: Previous studies have shown that restrictive fluid management can effectively reduce bleeding in liver transplantation, suggesting potential success for this approach.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * end stage liver disease * age between 18y/o to 75 y/o * expected to recieve to receive liver transplantation Exclusion Criteria: * arrythmia
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (Recruiting)
Study contacts
- Principal investigator: Kuang-Cheng Chan, M.D.,PhD. — Department of Anesthesiology, National Taiwan University Hospital
- Study coordinator: Kuang-Cheng Chan, M.D.,PhD.
- Email: jkjchan@gmail.com
- Phone: +886-2-23123456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.