Improving care for patients with alcohol-related liver disease undergoing liver transplant
Official title: 4/4: The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopsychosocial Outcomes of Early Liver Transplant for Alcohol-Associated Liver Disease
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-10908450 · Data updated 2026-11-12
This study is looking at how better teamwork in healthcare can help people with alcohol-related liver disease who are getting a liver transplant, focusing on what helps them get referred for the transplant and how to support their recovery and sobriety afterward.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2024 |
| Award (this year) | $392,871 |
| NIH project number | 7R01AA030969-02 |
| Project ID | NIH-10908450 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with alcohol-associated liver disease who are being considered for early liver transplant.
✕Less likely to help
Patients with liver disease not associated with alcohol or those who are not candidates for liver transplant may not benefit from this research.
What this research studies
This research investigates how integrated care can enhance the outcomes for patients with alcohol-associated liver disease who are undergoing early liver transplant. It aims to identify the factors that influence referrals for early liver transplant and develop models to predict patient-centered outcomes. The study will incorporate biopsychosocial measures to better understand the needs of diverse populations and evaluate how integrated care approaches can support patients in achieving abstinence from alcohol. By addressing these gaps, the research seeks to improve the overall care and recovery of patients post-transplant.
Why it matters
Potential benefit: If successful, this research could lead to improved survival rates and quality of life for patients with alcohol-associated liver disease undergoing liver transplant.
How similar studies have gone: Previous research has shown promising results with integrated care approaches for managing alcohol use disorders, suggesting potential for success in this study.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Mellinger, Jessica Leigh — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Mellinger, Jessica Leigh
Related research
Other NIH-funded projects on the same topics.
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Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
-
Biomarker-guided reduction of immunosuppression after liver transplant
A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.
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Understanding how liver disease progresses in people waiting for a liver transplant
A study will build a knowledge base that maps how liver disease worsens over time in patients on the transplant waitlist to improve care and planning.
-
Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
-
Pre-Transplant Immune Health Marker Panel to Predict Liver Transplant Outcomes
A patient-facing biomarker test used before liver transplant to help doctors estimate the risk of early death after the transplant.
-
Thinking skills and self-care after a liver transplant
This project follows people who received liver transplants to learn how changes in thinking and memory affect managing medicines, clinic visits, and overall health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.