Comparing techniques for preserving liver grafts from deceased donors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of three different organ preservation techniques—Normothermic Regional Perfusion (NRP), Dual Hypothermic Oxygenated Perfusion (DHOPE), and Controlled Normothermic Machine Perfusion (COR-NMP)—in improving the quality of liver grafts from donors after cardiac death (DCD). The study addresses the critical shortage of suitable liver grafts by exploring how these techniques can mitigate the risks associated with DCD grafts, such as primary non-function and biliary complications. By simulating physiological conditions during the initial hours post-cardiac death, the study seeks to enhance graft viability and reduce the need for retransplantation or patient morbidity.

Why it matters

Who can join: the full rules

Inclusion criteria:

* DCD donor (Maastricht type III and V)
* Age above 50 years old and below 75 years old

Exclusion criteria:

* Malignancy (except for primary non-metastatic central nervous system tumors, non-melanoma skin tumors or cured malignancies)
* Active infection (sepsis, meningitis, human immune deficiency virus, rubella, rabies, herpes zoster, tuberculosis)
* Intravenous drug abuse
* Unknown cause of death
* In the case of a NRP procedure: donors with a BMI above 35 and transaminases above 1000 U/I and not decreasing prior to donation are excluded

Where it's running

• Erasmus MC
  Rotterdam, South Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Jeroen de Jonge, Dr. — Erasmus Medical Center
• Study coordinator: Jeroen de Jonge, Dr.
• Email: j.dejonge.1@erasmusmc.nl
• Phone: +31643904182

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.