Condition

HIV Infection clinical trials and research

• 23Clinical trials
• 205NIH research projects
• 27Countries

Newest HIV Infection clinical trials

All recruiting trials (23)

• Expanding HIV-positive donor livers for HIV-positive recipients

  This study tests whether liver transplants from HIV-positive donors to HIV-positive recipients are safe regarding opportunistic infections and cancer.

  Recruiting at 2 sites National Institute of Allergy and Infectious Diseases (NIAID) · Baltimore, Maryland and 1 other locations · NCT07778459

• Optimizing HIV Therapy for AIDS-Related Lymphoma Patients

  This study tests whether long-acting HIV medicines given during lymphoma treatment work better at keeping the virus suppressed than standard oral therapy in adults with AIDS-related lymphoma.

  Recruiting Shanghai Public Health Clinical Center · Shanghai, Shanghai Municipality · NCT07727642

• Colchicine to see if it reduces coronary artery inflammation in people with HIV

  This study tests whether low-dose colchicine can lower inflammation in the coronary arteries of people with HIV who are at high heart-disease risk, compared with a placebo.

  Recruiting at 2 sites Phase 2 Instituto de Investigación Hospital Universitario La Paz · Barcelona and 3 other locations · NCT07704164

• Darunavir/ritonavir plus lamivudine vs darunavir/ritonavir plus tenofovir alafenamide/emtricitabine in virologically suppressed adults with HIV

  This trial tests whether a two-drug regimen (darunavir/cobicistat plus lamivudine) works as well as a three-drug regimen (darunavir/cobicistat plus TAF/FTC) in adults with HIV who have stable viral suppression.

  Recruiting Phase 4 Instituto Mexicano del Seguro Social · Mexico City, Mexico City · NCT07678268

• Dental care for people living with HIV in Pays de la Loire

  This study looks at whether people living with HIV in Pays de la Loire need any special dental management based on their health data.

  Recruiting Nantes University Hospital · Nantes, Nantes · NCT07552038

• Cardiovascular health in children and young adults with chronic conditions

  This project will see if children and young adults (ages 6-25) with chronic health conditions show early signs of aging in large and small blood vessels using noninvasive imaging and clinical tests.

  Recruiting Semmelweis University · Budapest and 2 other locations · NCT07086989

• DTG/3TC versus BIC/TAF/FTC as first-line HIV treatment for people new to antiretrovirals

  This trial will test whether DTG/3TC gives similar viral control but less weight gain and metabolic side effects than BIC/TAF/FTC in adults newly starting HIV treatment.

  Recruiting Phase 4 Instituto Mexicano del Seguro Social · Mexico City, Azcapotzalco · NCT07031063

• Comparing two HIV treatment regimens in men with suppressed viral loads

  This study is testing if a new combination of HIV medications can work just as well as the standard treatment for men who have their virus under control.

  Recruiting Phase 4 Instituto Mexicano del Seguro Social · Mexico City, Mexico City · NCT06907056

• AWARE.HIV Europe: supporting hospital teams to find undiagnosed HIV across Europe

  This project will test whether putting dedicated HIV teams into hospitals increases HIV testing for people who come in with conditions that could suggest HIV across ten European countries.

  Recruiting at 27 sites Erasmus Medical Center · Ghent and 27 other locations · NCT06900829

• Hormone therapy for hot flashes in women living with HIV

  This study tests whether transdermal estradiol (with or without progesterone) can relieve hot flashes and improve quality of life for women living with HIV who are going through menopause.

  Recruiting at 23 sites Phase 4 Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections · Birmingham, Alabama and 22 other locations · NCT06856174

• Offering different HIV prevention options to adolescents in Cape Town

  This study is testing whether giving young people in Cape Town a choice between three different HIV prevention methods helps them stick with their chosen option better over time.

  Recruiting Desmond Tutu HIV Foundation · Cape Town, Western Province · NCT06807736

• Reducing alcohol use and improving HIV treatment for men in fishing communities

  This study is testing a new program to help men with HIV in fishing communities cut down on drinking and stick to their HIV treatment to improve their health.

  Recruiting San Diego State University · Kampala · NCT06771843

• Multiplo HIV and syphilis self-test for adults

  This project will see if adults seeking HIV or syphilis testing can correctly use the Multiplo HIV/syphilis self-test to get accurate results.

  Recruiting at 3 sites Unity Health Toronto · Victoria, British Columbia and 2 other locations · NCT06716450

• Evaluating Codivir® with standard HIV treatment for newly diagnosed patients

  This study is testing if adding a new drug called Codivir® to standard HIV treatment can help newly diagnosed patients have better health outcomes.

  Recruiting Phase 2 Code Pharma · São Paulo · NCT06676410

• Heart transplants from HIV-positive donors for HIV-positive recipients

  This study is testing if heart transplants from both HIV-positive and HIV-negative donors are safe and effective for people living with HIV.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06659952

• Zinc supplements for people with HIV who haven't regained CD4 counts

  This trial will try zinc supplements to help adults with HIV who remain with low CD4 counts despite effective ART.

  Recruiting Parc de Salut Mar · Barcelona · NCT06612554

• Collecting blood and tissue samples for HIV/AIDS-related cancer research

  This study is collecting blood and tissue samples from people living with HIV and related cancers to help researchers learn more about how HIV affects cancer development.

  Recruiting at 8 sites AIDS Malignancy Consortium · La Jolla, California and 7 other locations · NCT05663502

• How gut immune tissue responds to HIV cure treatments

  This trial will test whether HIV cure–intent therapies change immune cells in the gut and lower tissue-associated HIV in people living with HIV.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT05652088

• CAR-T therapy for HIV-related aggressive B-cell lymphoma

  This study is testing a new CAR-T therapy to see if it can safely help people with HIV-related aggressive B-cell lymphoma that hasn't responded to other treatments.

  Recruiting at 7 sites Phase 1 AIDS Malignancy Consortium · Duarte, California and 6 other locations · NCT05077527

• Using smartphone support to help people with HIV quit smoking during lung cancer screening

  This study is testing whether a smartphone program can help people with HIV quit smoking while they are getting screened for lung cancer.

  Recruiting at 11 sites AIDS Malignancy Consortium · La Jolla, California and 10 other locations · NCT04949464

• Early intensive treatment for infants with HIV to achieve remission

  This study is testing whether starting strong HIV treatment right after birth can help infants with HIV reach undetectable levels of the virus.

  Recruiting at 25 sites Phase 1/2 National Institute of Allergy and Infectious Diseases (NIAID) · La Jolla, California and 46 other locations · NCT02140255

• ANRS CODEX 'Extreme' cohort of people who naturally control HIV

  This project tests blood markers in adults with long-term HIV control without antiretroviral therapy to learn what helps their immune system keep the virus in check.

  Recruiting ANRS, Emerging Infectious Diseases · Le Kremlin-Bicêtre · NCT01520844

• Comparing immune characteristics in HIV negative and HIV infected Thais

  This study is testing the differences in immune system features between HIV-negative people and those with non-acute HIV infection to learn more about how the virus affects the body.

  Recruiting SEARCH Research Foundation · Bangkok, Bangkok · NCT01397669

NIH-funded research (newest 40 of 205)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how genetic changes in blood cells relate to heart disease in people with HIV

  A study will look at how age-related blood cell mutations and large chromosomal changes might contribute to heart disease risk in people living with HIV.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11642564

• Cardiac health and protein markers in kids with perinatal HIV exposure or infection

  A study from Duke aims to understand heart health and protein biomarkers in children who were exposed to or infected with HIV at birth, especially in sub-Saharan Africa.

  NIH research Duke University · Durham, United States · NIH-11611413

• HBV cure clues in people with and without HIV

  This project studies how HBV-specific B and T cell responses relate to curing hepatitis B in people with and without HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11600326

• HBV cure factors in people with and without HIV

  This project studies how HBV-specific immune cells behave during treatment and whether people with HIV respond differently than those without HIV.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11600298

• Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa

  This project studies heart tissue changes in women with HIV in sub-Saharan Africa who are on antiretroviral therapy, to understand why they’re at higher risk for heart problems as they age.

  NIH research University of Washington · Seattle, United States · NIH-11594185

• Myocardial fibrosis and fat in ART-treated women with HIV in sub-Saharan Africa

  This grant studies heart tissue changes in women living with HIV in sub-Saharan Africa to understand why heart failure risk is higher in this group.

  NIH research University of Washington · Seattle, United States · NIH-11594184

• Outcomes in cirrhosis from different causes and the role of HIV and simvastatin

  This study looks at how cirrhosis from alcohol, HIV, and other causes affects patients and whether simvastatin can influence outcomes.

  NIH research Cleveland Clinic Lerner Com-Cwru · Cleveland, United States · NIH-11591516

• Testing and texting in dental clinics to fight HIV

  Aimed at making HIV prevention easier by testing patients in dental offices and exploring the use of a long-acting injectable PrEP in dental settings.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11576506

• Scaling up the brief alcohol support to prevent HIV in Vietnam

  A nationwide plan in Vietnam tests a practical, clinic-based approach to help people with HIV reduce alcohol use and improve HIV control.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11574733

• Understanding how sex affects early HIV-1 subtype C infection and treatment response

  Researchers are studying how men and women may experience subtype C HIV differently early after infection and during treatment, which could lead to more personalized care.

  NIH research Emory University · Atlanta, United States · NIH-11548392

• Tracking HIV Spread and Control in Africa

  A long-term study in Africa will follow people over time to see how HIV transmission, prevention, and testing affect the epidemic.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11535772

• How PrEP Drugs Affect HIV Risk in Women and Reproductive Health

  This project looks at how PrEP medicines work for women, and whether they influence pregnancy-related processes in the uterus.

  NIH research University of Nevada Reno · Reno, United States · NIH-11528077

• Vitamin D, gut bacteria and dementia risk in older adults with HIV

  This work will look at whether low vitamin D and changes in gut bacteria are linked to higher dementia risk in older adults living with chronic HIV and similar community members.

  NIH research Henry Ford Health + Michigan State University Health Sciences · East Lansing, United States · NIH-11517874

• Reducing heart disease risk in people with HIV by treating hidden CMV virus

  Treating hidden CMV replication in people living with HIV who are on ART may lower vascular inflammation and cardiovascular risk.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11420028

• HBV cure signals in people with and without HIV

  This project studies how HBV-specific immune responses differ in people with HIV compared to those without HIV who are being treated for hepatitis B, with the aim of understanding what parts of the immune system help achieve a cure.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11419816

• HIV Reservoirs and Metabolic Complications under ART

  This project looks at why aging people with HIV on stable treatment develop weight, liver, heart, and cancer problems, by studying how HIV persists in the body and affects metabolism.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11416550

• Gut bacteria, HIV, and alcohol: how microbes affect gut health in people with HIV

  This NIH grant studies how alcohol use and HIV together affect the gut’s bacteria and barrier, exploring a possible way to reduce gut inflammation in people living with HIV.

  NIH research Rush University Medical Center · Chicago, United States · NIH-11416474

• HIV infection and engineered B cell memory in a humanized mouse model

  Scientists are testing a new way to create HIV-fighting antibodies in a special mouse model to see if a functional cure could be possible without long-term antiretroviral therapy.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11411851

• How HIV hides in resting T cells when stimulated by endothelial cells

  A research project explores how HIV can persist in resting CD4+ T cells when they interact with endothelial cells in the body.

  NIH research Calvin University · Grand Rapids, United States · NIH-11409604

• Multimodal profiling of HIV and inflammation in brain immune cells

  This project studies how cocaine use and HIV infection affect immune cells in the brain, to find new ways to improve treatments and protect brain health.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11408757

• Cardiac health and protein biomarkers in kids with perinatal HIV exposure or infection

  A study to understand how perinatal HIV infection or exposure affects heart function and biomarkers in children and teens, to help prevent future heart problems.

  NIH research Duke University · Durham, United States · NIH-11408537

• CMV, immune activation, and early-life exposure shaping neurodevelopment in children born to mothers with HIV

  This project studies how exposure to maternal HIV and early CMV infection might affect a child’s brain development and behavior as they grow.

  NIH research University of Washington · Seattle, United States · NIH-11408475

• Drug, gut microbiome, and immune factors shaping birth and brain development in HIV-exposed but uninfected children

  This project will follow HIV-exposed but uninfected children to understand how maternal treatment, gut microbes, breastmilk sugars, and immune factors influence growth and brain development.

  NIH research University of Washington · Seattle, United States · NIH-11408459

• Cannabis and aging-related brain changes in people living with HIV

  This study looks at brain tissue after death to understand how cannabis use may affect Alzheimer’s-related brain changes in people living with HIV as they age.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11407813

• Understanding how sex affects early HIV-1 subtype C infection and treatment response

  This project looks at how HIV-1 subtype C behaves in men and women early after infection and during antiretroviral therapy, to see if sex differences influence disease course and treatment outcomes.

  NIH research Emory University · Atlanta, United States · NIH-11404813

• Lp(a) and HIV: Understanding Heart Disease Risk in HIV Patients

  This program looks at how Lipoprotein(a) contributes to higher heart disease risk in people with HIV and what Lp(a) levels mean for future treatments.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11402774

• Rapid social-network approach to fast HIV transmission response

  A new method uses people’s social networks and molecular clues to speed up linking recently diagnosed HIV patients to prevention and care.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11401407

• Heart and liver of the heart: understanding heart damage in HIV-positive women in Africa

  This study will look at heart damage and fat buildup in the hearts of women with HIV in sub-Saharan Africa to understand what predicts progression.

  NIH research University of Washington · Seattle, United States · NIH-11398264

• Scale up brief alcohol help to prevent HIV in Vietnam

  A large, real-world effort tests whether training clinic staff to use a brief alcohol intervention with people living with HIV can improve HIV viral control.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11396978

• Tracking HIV, alcohol use, and brain aging with MRI

  Aging people living with HIV who also have alcohol use disorder are being studied to understand how brain changes relate to balance, movement, and thinking over time using MRI.

  NIH research Sri International · Menlo Park, United States · NIH-11395398

• HIV infection, brain inflammation, and THC: exploring links to neurodegeneration

  A study in people with HIV will look at how brain inflammation and immune cells interact with THC to influence brain health.

  NIH research Tulane University of Louisiana · New Orleans, United States · NIH-11393999

• LINK: Connecting people to medicines that prevent opioid overdose and HIV

  This project uses telemedicine outreach and provider education to help people with opioid use disorder start and stay on medications that lower overdose and HIV risk.

  NIH research Boston Medical Center · Boston, United States · NIH-11393988

• How drugs like cocaine and cannabis may affect HIV treatment during pregnancy

  A study at Emory will look at how cocaine and cannabis use in pregnant people with HIV could interfere with HIV treatment at the placenta and impact healthy pregnancies.

  NIH research Emory University · Atlanta, United States · NIH-11393290

• Cell-type epigenomic study to find drug targets for people with HIV who use cannabis

  A study in people with HIV who use cannabis aims to map how cannabis changes DNA regulation in specific immune cells to find druggable genes that could help HIV treatment.

  NIH research Yale University · New Haven, United States · NIH-11392878

• Expanding a short alcohol counseling program to help prevent HIV in Vietnam

  This project will offer a brief alcohol counseling program in HIV clinics in Vietnam to help people with HIV drink less and lower the chance of passing HIV to others.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11388407

• Heart scarring and fat in women with HIV in sub-Saharan Africa

  This project uses advanced heart imaging to look for scarring and fat inside the hearts of women living with HIV on treatment in sub‑Saharan Africa.

  NIH research University of Washington · Seattle, United States · NIH-11387984

• Heart scarring and fat buildup in women living with HIV in sub-Saharan Africa

  This project looks at heart scarring and fat in women on HIV treatment in sub‑Saharan Africa to find early signs that lead to heart failure.

  NIH research University of Washington · Seattle, United States · NIH-11387983

• On-site HIV testing and text message prevention in community dental clinics

  A dental clinic-based program will offer rapid HIV testing and text-message prevention support to adults at risk in a Boston-area health system.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11386606

• Gut-disease signals linked to HIV and heart disease

  This project will look at how gut bacteria and related molecules are connected to heart and blood vessel problems in people living with HIV.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11380801

• Understanding how age-related blood changes affect heart disease risk in people with HIV

  This study looks at whether certain blood-level genetic changes and chromosome alterations in people living with HIV relate to higher risk of heart disease.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11379983

Related topics

Quick answers

How many HIV Infection clinical trials are recruiting right now?

23, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 27 countries. The most sites are in United States (8 trials), Mexico (3 trials), France (3 trials), Spain (3 trials), Brazil (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 4, Phase 2: 2, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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