Understanding how liver disease progresses in people waiting for a liver transplant
Official title: A Temporal Causal Knowledge Base of Liver Disease Progression in Liver Transplant Candidates
Funded at University of Florida · NIH-11428230 · Data updated 2026-11-12
A study will build a knowledge base that maps how liver disease worsens over time in patients on the transplant waitlist to improve care and planning.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project start | September 18, 2026 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $780,358 |
| NIH project number | 1R01DK148650-01 |
| Project ID | NIH-11428230 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with end-stage liver disease who are on or being considered for a liver transplant waitlist.
✕Less likely to help
Patients not on a liver transplant waitlist or those without a history of liver-related decompensation may see limited direct benefit.
What this research studies
This project looks at how liver disease and related health problems evolve for people waiting for a liver transplant. By linking patient history, worsening liver function, and complications over time, researchers aim to create a temporal map that can guide when to adjust care. The goal is to help clinicians anticipate needs, reduce hospitalizations, and ultimately improve survival for patients facing end-stage liver disease. The work uses existing patient data to build a causal-temporal framework that could inform future treatment decisions and organ allocation strategies.
Why it matters
Potential benefit: If successful, patients may experience better-timed care and potentially improved survival while on the transplant waitlist.
How similar studies have gone: Previous work highlights the value of longitudinal data in predicting outcomes, but this project advances by adding a temporal causal framework.
Where this research is happening
-
University of Florida
Gainesville, United States Active
Researchers
- Principal investigator: Pruinelli, Lisiane — University of Florida
- Study coordinator: Pruinelli, Lisiane
Related research
Other NIH-funded projects on the same topics.
-
Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
-
Biomarker-guided reduction of immunosuppression after liver transplant
A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.
-
Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
-
Pre-Transplant Immune Health Marker Panel to Predict Liver Transplant Outcomes
A patient-facing biomarker test used before liver transplant to help doctors estimate the risk of early death after the transplant.
-
Thinking skills and self-care after a liver transplant
This project follows people who received liver transplants to learn how changes in thinking and memory affect managing medicines, clinic visits, and overall health.
-
Integrated care to improve outcomes after early liver transplant for alcohol-associated liver disease
A multi-center study will pair liver transplant care with behavioral and biopsychosocial support to help people with alcohol-related liver disease who are considered for early transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.