Improving liver transplant success by targeting immune cells in donor livers
Targeting Donor Regulatory Dendritic Cells During Normothermic Ex Vivo Liver Perfusion to Overcome Rejection after Liver Transplant
This study is looking at a new way to improve liver transplants by changing certain immune cells in the liver before it's transplanted, which could help prevent the body from rejecting the new liver, making it better for patients who need a transplant.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project ID | NIH-11103165 on NIH RePORTER |
What this research studies
This research focuses on enhancing liver transplant outcomes by modifying immune cells in donor livers before transplantation. The approach involves using a technique called normothermic ex vivo machine perfusion (NEVLP), which keeps the liver in a physiologic state while allowing for immune cell modification. By targeting specific regulatory dendritic cells, the goal is to reduce the risk of transplant rejection, which is a significant barrier to successful liver transplantation. This research is led by an experienced surgeon-scientist at the University of Wisconsin-Madison, who is dedicated to advancing transplant immunology.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with end-stage liver disease who are awaiting liver transplantation.
Not a fit: Patients who have already received a liver transplant or those with conditions that preclude transplantation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved liver transplant acceptance and reduced need for lifelong anti-rejection medications.
How similar studies have performed: Similar approaches in transplant immunology have shown promise, indicating potential for success in this novel application.
Where this research is happening
Madison, United States
- University of Wisconsin-Madison — Madison, United States (Active)
Researchers
- Principal investigator: Al-Adra, David Peter — University of Wisconsin-Madison
- Study coordinator: Al-Adra, David Peter
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.