Immune signs that predict CMV after liver transplant
Immune signatures of CMV disease risk after orthotopic liver transplant
Looks for patterns in antibodies and immune cells that predict who will get CMV disease after a liver transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11330510 on NIH RePORTER |
What this research studies
If you had a liver transplant, researchers will study blood samples to measure CMV antibodies, neutralizing antibody activity, and immune cell markers. They will compare people who developed CMV disease after transplant with those who did not to find immune patterns linked to higher risk. The team will combine antibody measurements with T cell and NK cell profiles to build a risk signature. Some work will use stored samples from a previous liver transplant trial and new laboratory tests to refine a clinical risk tool.
Who could benefit from this research
Good fit: People who have received or will receive an orthotopic liver transplant, especially recipients whose donor was CMV-positive while the recipient was CMV-negative.
Not a fit: People who have not had a liver transplant or who are already CMV-seropositive are unlikely to benefit directly from this specific project.
Why it matters
Potential benefit: Could help doctors identify transplant patients at higher risk for CMV so antiviral prevention can be better targeted.
How similar studies have performed: Previous work, including the CAPSIL trial, showed pre-emptive therapy lowered CMV disease and linked T cell, NK cell, and neutralizing antibody changes to protection, but creating a combined humoral risk signature is a newer step.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Ford, Emily — University of Washington
- Study coordinator: Ford, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.