Biomarkers to tailor liver transplant immunosuppression

Who could benefit from this research

What this research studies

This project will follow liver transplant patients over time to see if measuring specific blood biomarkers can help personalize immunosuppressive therapy. By comparing standard care with biomarker-guided management, researchers aim to reduce rejection and kidney injury while keeping drug exposure effective. The study builds on prior CTOT-14 findings and uses modern biomarker platforms to track immune activation and organ injury. If successful, this approach could lead to more precise treatment and better long-term outcomes for patients. The trial is conducted across multiple centers with Northwestern University coordinating the effort.

Why it matters

Where this research is happening

• Northwestern University
  Chicago, United States Active

Researchers

• Principal investigator: Boike, Justin — Northwestern University
• Study coordinator: Boike, Justin

Related research

Other NIH-funded projects on the same topics.

• Using blood biomarkers to guide immunosuppression after liver transplant

  This project uses regular blood biomarker checks to help doctors personalize immunosuppression for people who have had a liver transplant to reduce rejection and protect the kidneys.

  NIH research Northwestern University · Chicago, United States · NIH-11392822

• Using blood biomarkers to improve liver transplant immunosuppression

  This study is looking at how certain blood tests can help doctors create personalized treatment plans for people who have received a liver transplant, making it easier to prevent rejection and protect kidney health.

  NIH research Northwestern University at Chicago · Chicago, United States · NIH-10888310

• Biomarker-guided reduction of immunosuppression after liver transplant

  A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11433277

• Improving liver transplant success by targeting immune cells in donor livers

  This study is looking at a new way to improve liver transplants by changing certain immune cells in the liver before it's transplanted, which could help prevent the body from rejecting the new liver, making it better for patients who need a transplant.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11103165

• Using miRNA profiles to improve immunosuppression management in liver transplant patients

  This study is looking at how certain tiny molecules in your blood can help doctors better manage the medications you take after a liver transplant, making sure your body doesn’t reject the new organ while reducing side effects.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-10841109

• Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury

  A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11594128

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.