Integrated care to improve outcomes after early liver transplant for alcohol-associated liver disease
4/4: The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopsychosocial Outcomes of Early Liver Transplant for Alcohol-Associated Liver Disease
Combining liver-transplant care with addiction and mental-health support to help people with alcohol-related liver disease who get early transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11190812 on NIH RePORTER |
What this research studies
My care team will gather medical, alcohol-use, and mental-health information before and after an early liver transplant at several transplant centers. The researchers will use standard questionnaires and clinical data to build models that predict outcomes like survival and return to drinking. The project tests how closely transplant and addiction services are coordinated and follows patients over time to see what kinds of support help recovery. Patients and other stakeholders help choose what outcomes matter most so results fit real-world needs.
Who could benefit from this research
Good fit: Adults with advanced alcohol-associated liver disease (including alcohol-associated hepatitis or cirrhosis) who are being evaluated for or receiving an early liver transplant, often with less than six months of abstinence.
Not a fit: People who are not candidates for liver transplant or whose liver disease is unrelated to alcohol are unlikely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could improve survival, reduce return-to-drinking, and guide better integrated support for people receiving early liver transplants for alcohol-related disease.
How similar studies have performed: Prior retrospective studies have shown acceptable outcomes for early transplant in alcohol-associated hepatitis, but prospective, multi-center work with standardized biopsychosocial measures is new.
Where this research is happening
East Lansing, United States
- Henry Ford Health + Michigan State University Health Sciences — East Lansing, United States (Active)
Researchers
- Principal investigator: Mellinger, Jessica Leigh — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Mellinger, Jessica Leigh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.