Integrated care to improve outcomes after early liver transplant for alcohol-associated liver disease
Official title: 4/4: The INTEGRATE Study: Evaluating INTEGRATEd care to Improve Biopsychosocial Outcomes of Early Liver Transplant for Alcohol-Associated Liver Disease
Funded at Henry Ford Health + Michigan State University Health Sciences · NIH-11398184 · Data updated 2026-11-12
A multi-center study will pair liver transplant care with behavioral and biopsychosocial support to help people with alcohol-related liver disease who are considered for early transplant.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Henry Ford Health + Michigan State University Health Sciences NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project start | August 16, 2023 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $375,468 |
| NIH project number | 5R01AA030969-04 |
| Project ID | NIH-11398184 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with advanced alcohol-associated liver disease being evaluated for early liver transplant at participating centers.
✕Less likely to help
Patients not considering early liver transplant or not enrolled at participating centers may not benefit.
What this research studies
This project looks at patients with alcohol-associated liver disease who are evaluated for early liver transplant and aims to understand how integrated care—including behavioral support for alcohol use and biopsychosocial factors—affects outcomes after transplant. It will collect data from multiple centers to build risk predictions for key patient-centered outcomes and test standardized measures of biopsychosocial health. The goal is to identify who benefits most from early transplant and to improve care pathways that support abstinence and long-term health after transplantation.
Why it matters
Potential benefit: If successful, patients may experience better post-transplant outcomes and more tailored, supportive care pathways.
How similar studies have gone: Previous studies suggest some benefit from integrated care, but prospective multi-center data in this area is limited and this study aims to fill that gap.
Where this research is happening
-
Henry Ford Health + Michigan State University Health Sciences
East Lansing, United States Active
Researchers
- Principal investigator: Mellinger, Jessica Leigh — Henry Ford Health + Michigan State University Health Sciences
- Study coordinator: Mellinger, Jessica Leigh
Related research
Other NIH-funded projects on the same topics.
-
Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
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-
Biomarker-guided reduction of immunosuppression after liver transplant
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-
Understanding how liver disease progresses in people waiting for a liver transplant
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Biomarkers to tailor liver transplant immunosuppression
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-
Pre-Transplant Immune Health Marker Panel to Predict Liver Transplant Outcomes
A patient-facing biomarker test used before liver transplant to help doctors estimate the risk of early death after the transplant.
-
Thinking skills and self-care after a liver transplant
This project follows people who received liver transplants to learn how changes in thinking and memory affect managing medicines, clinic visits, and overall health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.