Investigating how relaxin receptor signaling affects liver transplant injury and inflammation resolution
THE RELAXIN RECEPTOR GR/RXFP1 SIGNALING IN LIVER TRANSPLANT ISCHEMIA-REPERFUSION INJURY AND THE INFLAMMATION RESOLUTION
This study is looking at how a special protein called relaxin might help improve liver transplant success by reducing inflammation and damage during the surgery, and it's designed for people who are interested in better outcomes after liver transplants.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10906023 on NIH RePORTER |
What this research studies
This research focuses on understanding how the relaxin receptor (RXFP1) signaling pathway influences liver transplant outcomes, particularly in the context of ischemia-reperfusion injury (IRI). The study aims to explore the inflammatory response that occurs during liver transplantation and how it can be resolved to improve patient outcomes. By using advanced mouse models that express human RXFP1, researchers will investigate the protective effects of recombinant human relaxin-2 on liver cells and its potential to enhance recovery after transplantation. The findings could lead to new therapeutic strategies that improve the success rates of liver transplants.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage liver disease or tumors of hepatic origin who are undergoing liver transplantation.
Not a fit: Patients who are not candidates for liver transplantation or those with non-hepatic conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved recovery and long-term outcomes for patients undergoing liver transplantation.
How similar studies have performed: Previous studies have shown promising results with similar approaches in animal models, but this specific application in human liver transplantation is novel.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Kupiec-Weglinski, Jerzy W — University of California Los Angeles
- Study coordinator: Kupiec-Weglinski, Jerzy W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.