Improving medication adherence in adolescents after liver transplant
Official title: Improving Medication Adherence in adolescents who had a Liver Transplant: iMALT
Funded at Icahn School of Medicine at Mount Sinai · NIH-10891339 · Data updated 2026-11-12
This study is all about helping teenagers who have had a liver transplant remember to take their important medicine to keep their new liver healthy, using friendly phone calls and video chats to support them along the way.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 20, 2018 |
| Project end | August 31, 2025 |
| Funding year | 2023 |
| Award (this year) | $800,000 |
| NIH project number | 5U01DK119200-06 |
| Project ID | NIH-10891339 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adolescents who have undergone a liver transplant and exhibit signs of nonadherence to their immunosuppressant medications.
✕Less likely to help
Patients who are not adolescents or those who have not undergone a liver transplant may not benefit from this research.
What this research studies
This research focuses on enhancing the adherence of adolescent liver transplant recipients to their immunosuppressant medication regimens, which is crucial for preventing organ rejection. By utilizing a tailored telemetric intervention, the study aims to engage patients through remote communication methods such as phone calls and video chats. The intervention will address psychological barriers to self-care and provide reminders and problem-solving strategies to improve medication adherence. Participants will be monitored using the Medication Level Variability Index (MLVI) to assess their adherence levels and adjust interventions accordingly.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of organ rejection in adolescent liver transplant recipients by improving their medication adherence.
How similar studies have gone: Previous research has shown that telemetric interventions can effectively improve medication adherence in various patient populations, suggesting a promising approach for this study.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Shemesh, Eyal — Icahn School of Medicine at Mount Sinai
- Study coordinator: Shemesh, Eyal
Related research
Other NIH-funded projects on the same topics.
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Using technology to help young transplant recipients take their medications regularly
This study is all about helping young people who have had kidney or liver transplants remember to take their medications by using smart pillboxes that track when they take their meds, so they can get support right when they need it to stay healthy.
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Innate and Adaptive Immunoregulation in Liver Transplant Ischemia/Reperfusion Injury
A liver transplant-focused project investigates how the body’s early and later immune responses affect transplant failure or success after reperfusion.
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Biomarker-guided reduction of immunosuppression after liver transplant
A multicenter trial tests whether using blood biomarkers to guide tapering of immunosuppression in adults with liver transplants can keep people healthy while lowering drug exposure.
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Understanding how liver disease progresses in people waiting for a liver transplant
A study will build a knowledge base that maps how liver disease worsens over time in patients on the transplant waitlist to improve care and planning.
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Biomarkers to tailor liver transplant immunosuppression
A multi-center study using blood biomarkers to guide how immunosuppressive drugs are given to liver transplant patients.
-
Pre-Transplant Immune Health Marker Panel to Predict Liver Transplant Outcomes
A patient-facing biomarker test used before liver transplant to help doctors estimate the risk of early death after the transplant.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.