Using machine perfusion to improve liver transplants from steatotic donors

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of Normothermic Machine Perfusion (NMP) in resuscitating moderately steatotic livers for transplantation. The study will involve placing donor livers with 30-60% macrosteatosis on NMP and subsequently transplanting those that meet established viability criteria. By successfully demonstrating the viability of these livers, the trial could pave the way for future studies to include severely steatotic livers, thereby expanding the donor organ pool for liver transplants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80 years
* Listed for liver transplantation at MGH
* Calculated MELD-Na score \<= 25
* Able to consent

Exclusion Criteria:

* Status 1a
* Cardiac or pulmonary disease
* Prior liver transplant
* Requiring pressors at the time of liver offer
* MELD\<15 and asymptomatic from liver disease

Where it's running

• Massachusetts General Brigham
  Boston, Massachusetts, United States Recruiting

Study contacts

• Study coordinator: Heidi Yeh, MD
• Email: hyeh@mgh.harvard.edu
• Phone: 617-643-4533

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.