Condition

Congenital Heart Disease clinical trials and research

• 75Clinical trials
• 90NIH research projects
• 22Countries

Newest Congenital Heart Disease clinical trials

All recruiting trials (75)

• Adapting and testing PEN-Plus in Zambian primary care

  Aiming to see if the PEN-Plus package can be adapted and used in two Zambian hospitals to better manage chronic diseases like heart disease, diabetes, hypertension, and sickle cell in primary care.

  Recruiting Centre for Infectious Disease Research in Zambia · Lusaka, Lusaka Province · NCT07753681

• Wireless NIRS Sensor Use in the NICU for Monitoring on Neonates

  A wireless NIRS sensor is tested on infants in the NICU to see how well it stays on and how it notes brain signals when used alongside standard wired sensors.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07732244

• Screening for lipid disorders in children and teens with chronic diseases to flag cardiovascular risk

  This study tests a blood test and a questionnaire to screen children and teens with chronic conditions for lipid metabolism disorders and familial hyperlipidemia.

  Recruiting Jena University Hospital · Jena · NCT07716488

• Prehabilitation before heart surgery for adults with congenital heart disease

  This study is testing whether a tailored, supervised exercise program before heart surgery helps adults with congenital heart disease perform better and improve fitness.

  Recruiting Liverpool Heart and Chest Hospital NHS Foundation Trust · Liverpool · NCT07700459

• Accessible care model comparing nurse-led versus physician-led transition education for teens and young adults with congenital heart disease

  This project will test whether an accessible care model and nurse-led versus physician-led transition education helps teens and young adults (ages 12–26) with congenital heart disease move successfully from pediatric to adult heart care.

  Recruiting University of Wisconsin, Madison · Madison, Wisconsin · NCT07559253

• Surgical techniques and outcomes across the lifespan in congenital heart disease in China

  See which surgical factors and care patterns affect recovery after heart surgery for people with complex congenital heart disease in China.

  Recruiting China National Center for Cardiovascular Diseases · Beijing · NCT07524998

• Non-invasive 3D ECG mapping to guide arrhythmia care in congenital heart disease

  This project will test a non-invasive 3D ECG mapping system to see if it can pinpoint arrhythmia sources in people with congenital heart disease who are having invasive heart rhythm studies or device implants.

  Recruiting Fundacion para la Innovacion en Biomedicina (FIBMED) · Madrid, Madrid · NCT07425132

• Personalized lung volume optimization with PEEP titration for children after heart surgery or with severe respiratory failure

  This trial tests whether a personalized lung volume optimization maneuver using PEEP titration can improve heart and lung function in children after cardiopulmonary bypass surgery or in those with severe respiratory failure at risk for ECMO.

  Recruiting Phase 1/2 Charite University, Berlin, Germany · Tübingen · NCT07193719

• High‑calorie versus standard enteral feeding to support growth and brain development in infants after congenital heart surgery

  This trial tests whether higher‑calorie tube or bottle feeding helps infants with congenital heart disease grow better and support early brain development after open‑heart surgery.

  Recruiting Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT07115108

• Lifeline ductus arteriosus stent for infants with ductal-dependent circulation

  The trial will test whether the Lifeline ductus arteriosus stent safely keeps the ductus arteriosus open in infants under 6 months who need ductal-dependent pulmonary blood flow.

  Recruiting at 10 sites Starlight Cardiovascular Inc · Los Angeles, California and 10 other locations · NCT07114718

• Predicting postnatal circulation in pulmonary atresia with intact ventricular septum

  This project will try to use fetal ultrasound measurements to see if doctors can predict which babies with pulmonary atresia and an intact ventricular septum will have a biventricular/one-and-a-half repair versus need univentricular palliation by age 2.

  Recruiting Hospital Universitario 12 de Octubre · Madrid and 1 other locations · NCT07095829

• Maternal heart monitoring in pregnancies with fetal heart defects.

  This project uses a noninvasive heart monitor on pregnant women carrying a fetus with a congenital heart defect to see if the mother's blood flow and heart measurements are linked to the baby's heart problem and pregnancy outcomes.

  Recruiting Fondazione Policlinico Universitario Agostino Gemelli IRCCS · Roma · NCT07092644

• Longitudinal Assessment of Cardiac MRI Microstructure in Patients and Healthy People

  This study tests advanced, non-contrast and extended clinical cardiac MRI techniques to see how heart tissue features differ between people with heart disease and healthy individuals.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT07081711

• Parent Navigator Program to help Latino/x families of babies with congenital heart disease connect to developmental services

  This trial will test whether a Parent Navigator Program helps Latino/x parents of newborns with congenital heart disease connect to follow-up and early intervention services, improve child neurodevelopment, and reduce parental stress.

  Recruiting Children's Hospital Los Angeles · Los Angeles, California · NCT07023367

• SGLT2 Inhibition With Empagliflozin for Fontan Circulatory Failure

  We’re testing whether empagliflozin can help adults with Fontan circulatory failure feel better and do more in daily life.

  Recruiting at 2 sites Phase 3 Canadian Medical and Surgical Knowledge Translation Research Group · Vancouver, British Columbia and 1 other locations · NCT06955260

• Trauma, PTSD, and resilience in adults living with congenital heart disease

  This project will test whether lifetime experiences related to congenital heart disease are linked to PTSD and whether resilience helps protect adults with CHD.

  Recruiting Dartmouth-Hitchcock Medical Center · Washington D.C., District of Columbia and 2 other locations · NCT06952933

• Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease

  This study is trying to see if a new type of diabetes medication can help adults with congenital heart disease feel better and manage their heart failure symptoms.

  Recruiting at 11 sites Leiden University Medical Center · Baltimore, Maryland and 10 other locations · NCT06932081

• Improving fitness for adolescents with the Fontan circulation

  This study will test whether a home-based digital exercise program helps 10–17-year-olds with the Fontan circulation become more active and improve fitness compared with enhanced usual care.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06918795

• Monitoring pregnant women with congenital heart disease using wrist wearables

  This study is testing whether using wrist wearables to monitor the health of pregnant women with congenital heart disease can help track their condition and improve their care.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06818760

• Evaluating the link between vein size and heart pressure in children

  This study is trying to see if measuring the size of a specific vein in children's hearts can help predict their heart pressure.

  Recruiting IRCCS Azienda Ospedaliero-Universitaria di Bologna · Bologna, Bologna · NCT06776133

• High intensity interval training for patients with congenital heart defects

  This study is testing if a 12-week home workout program can help young people with certain heart defects exercise better and feel stronger.

  Recruiting Erasmus Medical Center · Nijmegen, Gelderland and 1 other locations · NCT06771687

• Integrated prenatal and postnatal treatment for newborns with critical congenital heart disease

  This study is testing a new approach that combines care before and after birth for newborns with serious heart defects to see if it can improve their treatment and recovery.

  Recruiting Beijing Anzhen Hospital · Beijing · NCT06768008

• Prenatal maternal mental health and infant brain development in congenital heart defects

  See if prenatal maternal psychological distress is linked to neurodevelopment at age one in babies with prenatally diagnosed critical cyanotic congenital heart defects who need neonatal open-heart surgery.

  Recruiting at 5 sites Institut National de la Santé Et de la Recherche Médicale, France · Marseille and 4 other locations · NCT06711666

• Investigating complex congenital heart defects in fetuses using multi-omics techniques

  This study is trying to find out what causes complex heart defects in unborn babies by looking at their genetic and environmental factors using samples from amniotic fluid.

  Recruiting University Hospital, Bordeaux · Bordeaux and 1 other locations · NCT06705543

• Comparing Entresto and placebo in patients with Tetralogy of Fallot and Ebstein's Anomaly

  This study is testing whether the heart medication Entresto can help people with Tetralogy of Fallot and Ebstein's Anomaly feel better and improve their heart function compared to a placebo.

  Recruiting Phase 3 Mayo Clinic · Rochester, Minnesota · NCT06693674

• Using Dapagliflozin to Improve Heart and Lung Function in Patients with Repaired Tetralogy of Fallot

  This study is testing if the medication Dapagliflozin can help improve heart and lung function in adults who have had surgery for Tetralogy of Fallot.

  Recruiting Phase 4 The University of Hong Kong · Hong Kong · NCT06668389

• New ultrasound technology for monitoring brain blood flow in sick newborns

  This study is testing a new ultrasound technology to see if it can help monitor blood flow in the brains of sick newborns and preterm infants.

  Recruiting St. Olavs Hospital · Trondheim · NCT06646250

• Digital health program for children with congenital heart disease and their families

  This study is testing a 12-week digital program using a fitness tracker to help children with congenital heart disease and their families become more active and improve their overall health.

  Recruiting Deutsches Herzzentrum Muenchen · München · NCT06626672

• Registry study on the life cycle of patients with congenital heart disease

  This study looks at how congenital heart disease affects patients in China from pregnancy through their entire lives to see how to improve their care and treatment.

  Recruiting Beijing Anzhen Hospital · Beijing, Beijing Municipality · NCT06611787

• A digital tool to empower adults with congenital heart disease

  This study is testing a digital tool called 'Empower My Congenital Health' to see if it helps adults with congenital heart disease feel more confident and engaged in managing their health.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06581484

• Evaluating pulse oximeter accuracy in children with congenital heart disease

  This study is testing how accurate pulse oximeters are for children with congenital heart disease, especially looking at how skin color might affect their readings before surgery.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT06575270

• Comparing hemodynamic assessments during rest and exercise for congenital heart disease

  This study is trying to see if checking blood flow problems in people with congenital heart disease is more effective when they are resting compared to when they are exercising.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06566196

• Body Voice AI for Childhood Heart and Lung Health

  Researchers are testing a body-sound AI device in children to help screen for heart and lung issues and related abdominal problems.

  Recruiting at 5 sites Xinhua Hospital, Shanghai Jiao Tong University School of Medicine · Wuhan, Hubei and 4 other locations · NCT06542120

• A cooperative initiative for individuals with congenital heart disease

  This study is trying to gather information from people with congenital heart defects, especially those with Hypoplastic Left Heart Syndrome, to help improve their care and treatment options in the future.

  Recruiting HeartWorks, Inc. · Rochester, Minnesota · NCT06469918

• Profiling micro RNA in newborns with congenital heart disease

  This study is trying to understand how certain molecules in the blood of newborns with severe congenital heart disease affect their risk of blood clots during surgery.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT06434207

• Biobank of stem cells and biomarkers for cardiovascular disease

  This study is creating a bank of stem cells and blood samples from people with heart disease to help researchers learn more about the condition and find better treatments.

  Recruiting London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · London, Ontario · NCT06371937

• Evaluating heart and muscle function during exercise in children with heart disease

  This study is testing how well the hearts and muscles of kids with heart disease work during exercise to see if a special workout program can help them get stronger and healthier.

  Recruiting University of Alberta · Edmonton, Alberta · NCT06325280

• Evaluating brain blood flow regulation in infants with congenital heart disease

  This study looks at how blood flow to the brain works in infants with congenital heart disease to see if it affects their brain development and helps create better follow-up care for them.

  Recruiting Universitaire Ziekenhuizen KU Leuven · Leuven, Vlaams-Brabant · NCT06190210

• Registry for patients with anomalous aortic origin of coronary arteries

  This study is collecting information from patients with a rare heart condition called anomalous aortic origin of coronary arteries to see how different treatments work and improve care for everyone.

  Recruiting at 2 sites University of Padova · Padova, PD and 1 other locations · NCT06089902

• Cardiohelp ECMO support for children with severe cardiac failure

  This study will test the Cardiohelp VA-ECMO system for up to 30 days and try heparin versus bivalirudin as anticoagulants in children (0–16 years) with severe heart failure who need VA-ECMO.

  Recruiting at 5 sites Phase 2 Stanford University · Palo Alto, California and 4 other locations · NCT06080074

• Virtual support program for parents of children with congenital heart disease

  This study is testing a virtual support program to see if it can help parents of young children with congenital heart disease improve their parenting skills and their child's behavior compared to regular care.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT06075251

• Local warming to improve arterial catheterization in young children

  This study tests if warming the skin before inserting a catheter can help young children having heart surgery have a better chance of a successful procedure.

  Recruiting Pusan National University Yangsan Hospital · Yangsan, Gyeongsangnam-do · NCT06041685

• Parent-child yoga to help children with congenital heart disease focus better

  This study is testing if parent-child yoga can help children with congenital heart disease focus better and improve their overall well-being.

  Recruiting at 2 sites St. Justine's Hospital · Montreal, Quebec and 1 other locations · NCT05997680

• Registry for tracking neurodevelopment in children with congenital heart disease

  This study is creating a national registry to track the development of young children with serious heart defects who have heart surgery early in life, to see how their health and treatments affect their growth and learning as they get older.

  Recruiting at 3 sites University Children's Hospital, Zurich · Bern and 2 other locations · NCT05996211

• Comparing two methods of breathing support after heart surgery in infants

  This study is testing which breathing support method, High Flow Nasal Cannula or Non-Invasive Positive Pressure Ventilation, works better for infants with heart defects after heart surgery.

  Recruiting Emory University · Atlanta, Georgia · NCT05869825

• Treatment for Sinus Venosus Defect

  This study is testing a new less invasive stent treatment for people with a heart condition called sinus venosus defect who can't have traditional surgery.

  Recruiting at 3 sites Centre Chirurgical Marie Lannelongue · Bordeaux and 12 other locations · NCT05865119

• Registry for patients with congenital heart disease

  This study is gathering information from adults with congenital heart disease to better understand their health and improve care for them.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05849025

• Copenhagen Baby Heart Study - Impact

  This study looks at how common undetected heart problems are in newborns and their effects during early childhood, while also checking heart health in Danish kids.

  Recruiting at 3 sites Copenhagen University Hospital, Rigshospitalet · Copenhagen Ø and 2 other locations · NCT05838079

• Effects of stenting on exercise capacity in patients with certain congenital heart defects

  This study is testing if a procedure to open blocked arteries can help people with certain heart defects, like d-TGA, ToF, and TA, exercise better.

  Recruiting UMC Utrecht · Amsterdam and 3 other locations · NCT05809310

• Using a bedside decision-support tool to shorten ventilator time after pediatric heart surgery

  This test will see if a computer decision-support tool can help clinicians shorten the time children under 12 spend on a ventilator after congenital heart surgery.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT05687292

• Examining factors affecting fitness in patients who had the Fontan procedure

  This study looks at how lung function affects fitness in people who have had the Fontan procedure for congenital heart disease.

  Recruiting Hacettepe University · Ankara · NCT05684562

• Neuro-cardiac rehabilitation for children and young adults with complex congenital heart disease

  This program will test whether a 12-week home-based neuro-cardiac rehabilitation program can improve quality of life, mental health, and exercise capacity in 8–25-year-olds with complex congenital heart disease.

  Recruiting at 5 sites University Hospital, Bordeaux · Brussels and 5 other locations · NCT05670132

• Development of advanced MRI techniques for heart disease assessment

  This study is testing new MRI techniques to see how heart tissue differs between people with heart disease and healthy individuals to improve heart assessments.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT05654272

• Using lab-grown heart cells to treat congenital heart disease

  This study is testing if using heart cells made from patients' own skin can safely help people with congenital heart disease feel better.

  Recruiting Phase 1 HeartWorks, Inc. · Rochester, Minnesota · NCT05647213

• Screening for critical congenital heart disease using a machine learning algorithm

  This study is testing a new computer program to see if it can better screen newborns for serious heart problems using simple measurements like blood oxygen levels.

  Recruiting University of California, Davis · Davis, California and 2 other locations · NCT05637814

• Collection of blood samples to study pediatric heart disease

  This study is collecting blood samples from kids with congenital heart disease to see if they can create special cells that help researchers understand and treat heart problems in children better.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT05550324

• Evaluating fetal aortic valve balloon dilation for congenital heart defects

  This study is testing whether a procedure called fetal aortic valvuloplasty can help fetuses with aortic valve problems caused by hypoplastic left heart syndrome feel better and have better outcomes.

  Recruiting at 13 sites Queen Silvia Children's Hospital, Gothenburg, Sweden · San Francisco, California and 12 other locations · NCT05386173

• Registry of cardiac arrests in children with congenital heart disease

  This study is collecting information on cardiac arrests in children with congenital heart disease in Germany to see how these events affect their recovery and overall health.

  Recruiting Leipzig Heart Science gGmbH · Leipzig, Saxony and 2 other locations · NCT05373498

• Assessing heart function in children with single-ventricle congenital heart disease

  This study is testing a new 3D heart imaging technique to see if it can better measure heart size and function in children and young adults with a specific type of heart defect compared to the standard MRI method.

  Recruiting Duke University · Durham, North Carolina · NCT05262907

• Understanding liver disease in patients with congenital heart disease

  This study is trying to understand liver problems in people who have had heart surgery for congenital heart disease to see how it affects their health over time.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05213598

• Understanding heart issues in patients with congenital heart disease

  This study is trying to understand what causes symptoms like shortness of breath and palpitations in people with congenital heart disease, especially those with Tetralogy of Fallot, by using remote heart monitoring.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05122962

• New imaging protocol for heart conditions

  This study is testing a new imaging method for heart conditions to see if it can improve diagnosis and treatment for over 10,000 patients with heart issues.

  Recruiting Fatebenefratelli Hospital · Benevento · NCT05081115

• Registry for adults with congenital heart disease and heart transplantation

  This study is collecting information about adults with congenital heart disease who may need a heart transplant to better understand their experiences and outcomes.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg, Free and Hanseatic City of Hamburg · NCT04848844

• Home-based high intensity interval training for youth with congenital heart disease

  This study is testing if a home workout program using a special bike can help kids and teens with heart problems get stronger and feel better over eight weeks.

  Recruiting University of Alberta · Edmonton, Alberta · NCT04575883

• A quick 10-minute heart scan for cardiac diseases

  This study is testing a quick 10-minute heart scan to see if it can help diagnose heart problems better and faster for many patients without needing special dyes.

  Recruiting McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT04464655

• Evaluating immune cell activity in patients undergoing heart surgery

  This study is trying to see how immune cell activity during heart surgery affects the risk of blood clots in patients.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04299828

• Using 3D printed heart models for surgical planning in children with congenital heart disease

  This study tests if using 3D printed heart models can help doctors plan better surgeries for children with congenital heart disease who need a heart device.

  Recruiting at 5 sites Columbia University · Palo Alto, California and 5 other locations · NCT03891160

• Registry of patients with Tetralogy of Fallot using implantable defibrillators

  This study is creating a national registry to track adult patients in France with Tetralogy of Fallot who have implantable defibrillators, to better understand their health over time.

  Recruiting Paris Sudden Death Expertise Center · Paris · NCT03837574

• Monitoring fetal heart activity in high-risk pregnancies to prevent stillbirth

  This study is testing a new way to monitor fetal heart activity in high-risk pregnancies to see if it can help prevent stillbirth.

  Recruiting at 2 sites Medical College of Wisconsin · Madison, Wisconsin and 1 other locations · NCT03775954

• Nutrition management for infants undergoing heart surgery

  This study is testing how managing nutrition before and after heart surgery can help infants with congenital heart disease recover better and improve their long-term health.

  Recruiting Guangzhou Medical University · Hangzhou, Zhejiang · NCT03626480

• Observing the effectiveness of pacing therapy for congenital heart disease patients with atrial arrhythmias

  This study is testing how well pacing therapy works for people with congenital heart disease who have heart rhythm problems and already have devices to help manage them.

  Recruiting at 9 sites University of Iowa · Los Angeles, California and 14 other locations · NCT03209583

• Registry for adults with congenital heart disease in Switzerland

  This study is collecting information from adults with congenital heart disease in Switzerland to better understand their health and improve their treatment options.

  Recruiting at 6 sites University Hospital, Basel, Switzerland · Basel and 5 other locations · NCT02258724

• Using simvastatin to protect the heart during cardiac surgery

  This study tests if simvastatin can help protect the heart and improve recovery for patients having cardiac surgery for heart defects or valve problems.

  Recruiting Sun Yat-sen University · Guangzhou, Guangdong · NCT01653223

• Exploring the genetics behind congenital heart disease

  This study is trying to find out the genetic reasons behind congenital heart disease by looking at the DNA of people with the condition and their families.

  Recruiting Nationwide Children's Hospital · Columbus, Ohio · NCT01192048

• Characterizing heart tissue development in infants with congenital heart disease

  This study looks at heart tissue from infants with congenital heart disease to see how it works differently than in adults, hoping to find better treatments for these conditions.

  Recruiting Emory University · Atlanta, Georgia · NCT00243776

NIH-funded research (newest 40 of 90)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multimodal AI to improve genetic diagnosis of congenital heart disease

  A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11625643

• Multimodal AI to improve genetic diagnosis of congenital heart disease

  A big AI project will help doctors and families by better identifying genetic causes of congenital heart defects using imaging, medical data, and genome information.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11573169

• Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains

  This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11520488

• Newborn brain injury risk during birth transition in babies with congenital heart defects

  This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11474556

• Heart development study using patient stem cells to understand NOTCH1 and congenital heart disease

  A study using patient-derived stem cells and genome editing to learn how NOTCH1 affects early heart development and congenital heart defects in humans.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11448014

• AI-powered echocardiography to spot common heart defects in newborns

  A new AI tool analyzes infant heart ultrasound images to help non-specialist health workers identify five common, treatable heart defects early.

  NIH research Health Research Foundation · Buea, CAMEROON · NIH-11446295

• Genetic clues to congenital heart defects and outcomes

  This grant studies how genetic differences contribute to congenital heart defects (CHD) and how these variations affect health over time, with patient data from a large biobank and health records.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11422502

• Linking Medicaid and Heart Registry Data to understand disparities in outcomes for children with congenital heart disease

  A patient-facing summary: researchers are linking Medicaid data with heart surgery registries to understand why outcomes differ for children with congenital heart disease and how the healthcare system may influence those differences.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11417907

• Metabolic Changes Driving Pulmonary Vessel Disease in Congenital Heart Disease with New Collagen Pathway

  This grant studies how metabolic changes in the lungs of children with congenital heart disease and high blood flow may lead to damaging blood vessel changes, with a focus on a collagen pathway.

  NIH research Florida International University · Miami, United States · NIH-11401950

• CHD Young Adults: Boosting Activity with a Virtual Lifestyle Program

  A program helps teens and young adults with congenital heart disease become more physically active through face-to-face online sessions and self-monitoring.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11383133

• CDK13’s role in heart development and congenital heart disease

  Aims to understand how CDK13 gene changes cause congenital heart defects by studying mouse and stem cell models to explore heart development and RNA processing.

  NIH research University of South Florida · Tampa, United States · NIH-11378820

• Cell-based brain protection for infants with congenital heart defects

  This project uses bone marrow-derived mesenchymal cells given through the heart-lung machine during surgery to help protect the brains of infants and young children with congenital heart defects.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11375931

• Gut bacteria and increased inflammation after heart bypass in children with congenital heart defects

  This project will look at whether an unhealthy gut microbiome in children with congenital heart defects makes inflammation and gut barrier damage worse after cardiopulmonary bypass surgery.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11362104

• Fetal heart disease and placental blood flow in pregnancy

  A mother-and-child focused project to understand how placental blood flow in pregnancies with fetal heart disease affects the baby’s brain development.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11352386

• Altered lymphatic function in congenital heart disease

  A study in people and animal models examines how congenital heart disease affects the lymphatic system and its role in related health problems.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11350882

• Lipid damage and mitochondria: new ways to protect the Fontan heart

  A Stanford-led study aims to find new targets and biomarkers to preserve heart function in children with Fontan circulation by looking at how oxidative stress damages heart cell powerhouses and affects blood vessels.

  NIH research Stanford University · Stanford, United States · NIH-11330408

• Finding hidden genetic causes of congenital heart disease in newborns

  A study to uncover genetic reasons behind congenital heart defects in babies by examining both coding and non-coding DNA to explain cases that are currently unexplained.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11323997

• How heart valves form before birth in babies with congenital heart disease

  This project looks at how abnormal blood flow before birth changes the developing aortic and pulmonary valves in babies with Tetralogy of Fallot.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11323549

• Cord clamping choices for babies with congenital heart disease

  This study asks which cord-clamping approach (delayed or immediate) is better for newborns with congenital heart disease.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11318952

• Protecting newborn brains in babies born with transposition of the great arteries

  Doctors will follow babies with transposition of the great arteries from pregnancy through birth to find early signs and ways to protect their brains during the newborn transition.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11306049

• How the SHROOM3 gene may cause congenital heart defects

  This work looks at how changes in the SHROOM3 gene can lead to congenital heart problems in babies.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11299565

• HD-DOT bedside brain monitoring in children with congenital heart disease

  A small NIH-funded project will test a portable brain-imaging method to monitor brain function and oxygen use during perioperative care in babies and children with congenital heart disease.

  NIH research Washington University · Saint Louis, United States · NIH-11296423

• Brain injury risks in preterm newborns with congenital heart disease

  This grant studies how being born preterm with congenital heart disease affects brain development and injury, to help improve outcomes for affected babies.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11295488

• Understanding genetic changes behind congenital heart defects

  This project aims to find how different DNA changes, including those outside genes, can disrupt heart development in people with congenital heart defects.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11264817

• Kidney problems after congenital heart surgery in children

  This project follows children who had congenital heart surgery to learn how heart defects and surgery relate to high blood pressure and kidney disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11262317

• Fetal brain MRI to predict later development in babies with congenital heart defects

  This project uses MRI before birth to try to predict which babies with congenital heart defects might have learning or developmental challenges later.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11248333

• Lung blood vessel changes in children with congenital heart defects that increase blood flow

  This project looks at how changes in cell metabolism and collagen production in lung blood vessels may cause pulmonary vascular disease in children born with heart defects that raise blood flow to the lungs.

  NIH research Florida International University · Miami, United States · NIH-11198731

• Creating 3D models to improve heart surgery for children with severe congenital heart disease

  This study is all about helping kids with serious heart problems by using special 3D models of their hearts, so doctors can plan the best surgery for each child and make sure they have the best chance of a successful recovery.

  NIH research West Virginia University · Morgantown, United States · NIH-11180747

• Understanding how heart structures develop and lead to congenital heart disease

  This study is looking at how the heart's wall forms to help prevent heart problems in babies, focusing on certain genes that might cause issues if they don't work right, with the hope of improving early detection and treatment for kids with heart defects.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11175773

• AI tracking of ECG changes in adults born with heart defects

  This project uses artificial intelligence to spot gradual changes in ECGs of adults born with heart defects so worsening heart problems can be caught earlier.

  NIH research Emory University · Atlanta, United States · NIH-11141170

• Personalized 3D-printed heart models to plan VAD surgery for congenital heart disease

  This project uses personalized 3D-printed heart models to help surgeons plan ventricular assist device and cannula placement for people with congenital heart disease and heart failure.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11134573

• Understanding long-term outcomes and care differences for children born with heart defects

  This project links surgical registry and Medicaid records to learn why children with congenital heart defects have different long-term health and care experiences.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11134076

• Identifying genes linked to congenital heart disease

  This study is looking at the genes that might cause congenital heart disease in kids, hoping to find out why some children with certain genes don’t develop the condition, which could help doctors create better ways to diagnose and treat affected children.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11124441

• Brain connections and thinking skills in people with congenital heart disease

  Researchers will compare brain wiring and thinking skills in infants, children, and adults with congenital heart disease to find markers that predict who may struggle with attention, planning, and other executive functions.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11124082

• Physical activity program for teens and young adults with congenital heart disease

  This program helps teens and young adults with congenital heart disease get more moderate-to-vigorous activity through tailored video coaching and activity tracking.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11122224

• Improving care for young adults with congenital heart disease and addressing health equity in pediatric care

  This study is looking to improve healthcare for young adults with congenital heart disease as they move from children's to adult care, especially for those from diverse backgrounds or lower-income families, by training new researchers to help make healthcare fairer for everyone.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11120941

• Understanding how genes and environment cause congenital heart disease

  This project explores how a person's genes and their environment work together to cause congenital heart disease, a common birth defect.

  NIH research University of California at Davis · Davis, United States · NIH-11118827

• Finding genetic causes of congenital heart disease

  This study is looking at the genes of babies with congenital heart disease to find out what might be causing their heart problems, which could help doctors understand and treat this condition better in the future.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11094004

• Lymphatic Changes in Congenital Heart Disease

  This project looks at how lymphatic vessels develop and function differently in people with congenital heart disease, especially those with increased blood flow to the lungs.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11091476

• Understanding how certain cells contribute to heart development issues.

  This study is looking at how certain cells in the developing heart work together and what goes wrong in congenital heart disease, with the hope that understanding these processes can help improve treatments for patients with heart defects.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11087480

Related topics

Quick answers

How many Congenital Heart Disease clinical trials are recruiting right now?

75, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (32 trials), Canada (10 trials), Germany (8 trials), China (7 trials), France (5 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 1, Phase 1/2: 1, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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