Cord clamping choices for babies with congenital heart disease
Official title: 1/2 CORD-CHD: Clamp OR Delay among neonates with Congenital Heart Disease
Funded at Research Inst Nationwide Children's Hosp · NIH-11318952 · Data updated 2026-11-12
This study asks which cord-clamping approach (delayed or immediate) is better for newborns with congenital heart disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Research Inst Nationwide Children's Hosp NIH-funded |
| Lab location | 1 site (Columbus, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $1,038,579 |
| NIH project number | 5UH3HL166794-04 |
| Project ID | NIH-11318952 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are newborns with diagnosed or suspected congenital heart disease and their mothers, in facilities capable of delivering and supporting the trial.
✕Less likely to help
Some infants may not experience meaningful benefit depending on their specific heart condition or birth circumstances.
What this research studies
In this trial, babies born with a congenital heart condition are randomized to receive delayed cord clamping or immediate clamping at birth. The team will monitor outcomes related to blood transfer at birth, iron status, and early neurodevelopment to see which method offers more benefit. By comparing these two practical options, the study aims to guide obstetricians and neonatologists in the birth management of high-risk infants. The trial is designed to be rigorous and applies lessons from past cord-clamping research to a vulnerable population.
Why it matters
Potential benefit: If successful, the findings could help clinicians choose the clamping method that improves iron status and neurodevelopment for newborns with congenital heart disease.
How similar studies have gone: Previous studies in healthy term babies showed benefits of delayed clamping, but this trial focuses on a high-risk group where results are not yet known.
Where this research is happening
-
Research Inst Nationwide Children's Hosp
Columbus, United States Active
Researchers
- Principal investigator: Backes, Carl — Research Inst Nationwide Children's Hosp
- Study coordinator: Backes, Carl
Related research
Other NIH-funded projects on the same topics.
-
Multimodal AI to improve genetic diagnosis of congenital heart disease
A new AI tool uses multiple types of patient data to help doctors find genetic causes of congenital heart disease more accurately.
-
Multimodal AI to improve genetic diagnosis of congenital heart disease
A big AI project will help doctors and families by better identifying genetic causes of congenital heart defects using imaging, medical data, and genome information.
-
Brain injury risk in preterm babies with heart disease and how surgery choices affect their brains
This project follows newborns with congenital heart disease born early to understand how their brains are affected and how different surgical approaches might influence outcomes.
-
Newborn brain injury risk during birth transition in babies with congenital heart defects
This project will look at how circulation changes around birth affect newborn brain health in babies with transposition of the great arteries.
-
Heart development study using patient stem cells to understand NOTCH1 and congenital heart disease
A study using patient-derived stem cells and genome editing to learn how NOTCH1 affects early heart development and congenital heart defects in humans.
-
AI-powered echocardiography to spot common heart defects in newborns
A new AI tool analyzes infant heart ultrasound images to help non-specialist health workers identify five common, treatable heart defects early.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.