NIH-funded research R21 grant

AI-powered echocardiography to spot common heart defects in newborns

Official title: AI-facilitated Echocardiography for Early Detection of Acyanotic Congenital Heart Disease in Infants

Funded at Health Research Foundation · NIH-11446295 · Data updated 2026-11-12

A new AI tool analyzes infant heart ultrasound images to help non-specialist health workers identify five common, treatable heart defects early.

More Heart Disease research and trials

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionHealth Research Foundation
NIH-funded
Lab location1 site (Buea, CAMEROON)
Project startSeptember 18, 2026
Project endAugust 31, 2028
Funding year2026
Award (this year)$74,995
NIH project number1R21HL188666-01
Project IDNIH-11446295 on NIH RePORTER

Who could benefit from this research

Could help

Infants aged 0–12 months evaluated in settings with limited access to pediatric cardiology.

Less likely to help

If there is no access to echocardiography or trained personnel, the AI tool may not be deployable.

What this research studies

This project aims to create AI models that can automatically detect five common acyanotic congenital heart defects (ASD, VSD, AVSD, COA, PDA) in infants using postnatal echocardiography. Building on prior work that automated basic cardiac view identification, the team will adapt models to recognize specific defects and landmarks, leveraging datasets from South Africa and Cameroon. The goal is to enable nurses, midwives, general practitioners, and sonographers in low-resource settings to screen for these conditions where specialists are scarce. The project will use convolutional neural networks to identify anatomical features and patterns associated with each CHD directly from echocardiogram videos. Overall, the work seeks to deliver a practical, point-of-care AI tool that supports earlier detection and timely referral for treatment.

Why it matters

Potential benefit: If successful, babies with acyanotic CHDs could be diagnosed earlier, enabling faster treatment and better outcomes.

How similar studies have gone: Previous work automated general echocardiography view identification; this project extends to specific CHD detection in real-world, low-resource settings.

Where this research is happening

  • Health Research Foundation
    Buea, Cameroon
    Active

Researchers

  • Principal investigator: Leke, Aminkeng Zawuo — Health Research Foundation
  • Study coordinator: Leke, Aminkeng Zawuo

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.