Kidney problems after congenital heart surgery in children
Official title: Kidney-Associated Diseases after Congenital Heart disease surgery In Children
Funded at Johns Hopkins University · NIH-11262317 · Data updated 2026-11-12
This project follows children who had congenital heart surgery to learn how heart defects and surgery relate to high blood pressure and kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | March 15, 2024 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $698,167 |
| NIH project number | 5R01DK135518-03 |
| Project ID | NIH-11262317 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children who had congenital heart surgery about 4–8 years ago, especially those with single-ventricle defects like hypoplastic left heart syndrome, are the intended participants.
✕Less likely to help
Children without congenital heart defects, those who never had cardiac surgery, or people not seen at participating hospitals are unlikely to be eligible or directly benefit.
What this research studies
If you join, the team will enroll about 350 children who had their first congenital heart surgery 4–8 years ago at four U.S. children's hospitals. They will focus on children with single-ventricle conditions such as hypoplastic left heart syndrome and other high-risk defects. Participants will come for in-person visits where doctors check blood pressure, measure kidney function, and collect medical history and tests over time. The study aims to map who develops high blood pressure or chronic kidney disease after heart surgery so care can be improved earlier.
Why it matters
Potential benefit: If successful, the work could identify children with congenital heart disease who need earlier monitoring or treatment to prevent or slow kidney disease and high blood pressure.
How similar studies have gone: Previous research has shown higher rates of hypertension and kidney disease in people with congenital heart disease, but long-term pediatric cohorts focused on high-risk surgical groups are relatively limited.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Parikh, Chirag R — Johns Hopkins University
- Study coordinator: Parikh, Chirag R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.