Kidney problems after congenital heart surgery in children
Kidney-Associated Diseases after Congenital Heart disease surgery In Children
This project follows children who had congenital heart surgery to learn how heart defects and surgery relate to high blood pressure and kidney disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11262317 on NIH RePORTER |
What this research studies
If you join, the team will enroll about 350 children who had their first congenital heart surgery 4–8 years ago at four U.S. children's hospitals. They will focus on children with single-ventricle conditions such as hypoplastic left heart syndrome and other high-risk defects. Participants will come for in-person visits where doctors check blood pressure, measure kidney function, and collect medical history and tests over time. The study aims to map who develops high blood pressure or chronic kidney disease after heart surgery so care can be improved earlier.
Who could benefit from this research
Good fit: Children who had congenital heart surgery about 4–8 years ago, especially those with single-ventricle defects like hypoplastic left heart syndrome, are the intended participants.
Not a fit: Children without congenital heart defects, those who never had cardiac surgery, or people not seen at participating hospitals are unlikely to be eligible or directly benefit.
Why it matters
Potential benefit: If successful, the work could identify children with congenital heart disease who need earlier monitoring or treatment to prevent or slow kidney disease and high blood pressure.
How similar studies have performed: Previous research has shown higher rates of hypertension and kidney disease in people with congenital heart disease, but long-term pediatric cohorts focused on high-risk surgical groups are relatively limited.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Parikh, Chirag R — Johns Hopkins University
- Study coordinator: Parikh, Chirag R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.