Understanding how certain cells contribute to heart development issues.
Official title: Molecular pathogenesis of congenital heart disease mediated by neural crest and second heart field cells
Funded at Albert Einstein College of Medicine · NIH-11087480 · Data updated 2026-11-12
This study is looking at how certain cells in the developing heart work together and what goes wrong in congenital heart disease, with the hope that understanding these processes can help improve treatments for patients with heart defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albert Einstein College of Medicine NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | May 12, 2022 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $567,187 |
| NIH project number | 5R01HL163667-04 |
| Project ID | NIH-11087480 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with congenital heart disease, particularly those with conditions related to 22q11 chromosomal microdeletion syndrome.
✕Less likely to help
Patients with congenital heart disease not associated with neural crest or second heart field cell involvement may not benefit from this research.
What this research studies
This research investigates the molecular mechanisms behind congenital heart disease, particularly focusing on the interactions between neural crest cells and second heart field cells during embryonic development. By utilizing advanced techniques like single cell RNA sequencing, the study aims to identify specific cell populations involved in heart formation and their roles in cardiac defects. Patients may benefit from insights gained about the genetic and cellular factors that lead to heart malformations, potentially guiding future therapies or interventions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for congenital heart disease.
How similar studies have gone: Previous research has shown promise in understanding congenital heart disease through similar cellular and genetic approaches, indicating potential for success in this area.
Where this research is happening
-
Albert Einstein College of Medicine
Bronx, United States Active
Researchers
- Principal investigator: Morrow, Bernice E — Albert Einstein College of Medicine
- Study coordinator: Morrow, Bernice E
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.