Characterizing heart tissue development in infants with congenital heart disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the molecular and cellular characteristics of cardiac tissue in infants undergoing surgery for congenital heart disease. Researchers will analyze small samples of heart tissue to understand how calcium ions regulate heart cell contraction differently in infants compared to adults. The study will also explore the development of human pluripotent stem cell-derived cardiomyocytes in a 3D environment to enhance their functional and metabolic maturation. By examining these differences, the study seeks to improve therapeutic approaches for congenital heart conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients undergoing cardiopulmonary bypass surgery
* Patients undergoing surgery for repair of congenital heart disease such as ventricular septal defect or defective mitral or aortic valves.

Exclusion Criteria:

* Prior cardiac surgery
* History of atrial fibrillation or other atrial arrhythmias prior to operation
* History of heart failure

Where it's running

• Emory University School of Medicine
  Atlanta, Georgia, United States Recruiting

Study contacts

• Principal investigator: Michael E Davis, PhD — Emory University
• Study coordinator: Michael E Davis, PhD
• Email: medavis@emory.edu
• Phone: 404-727-9858

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.